2016
DOI: 10.18632/oncotarget.8029
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Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers

Abstract: Resident mesenchymal stem cells (MSCs) promote cancer progression. However, pathways and mechanisms involved in recruiting MSCs into breast tumors remain largely undefined. Here we show that geminin-dependent acetylation releases HMGB1 from the chromatin to the cytoplasm and extracellular space. Extracellular acetylated HMGB1 (Ac-HMGB1) promotes geminin overexpressing (GemOE) cells survival by binding to RAGE and activating NF-κB signaling. Extracellular Ac-HMGB1 also triggers expression and activation of RAGE… Show more

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Cited by 21 publications
(32 citation statements)
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“…Large experimental groups of animals are needed considering the sample volume and number of samples need to be taken for estimation of peak concentration in tissue and time to achieve maximum concentration in tissue. As patient acceptance is less regarding multiple drug dosages, sustained release formulations are being developed [26]. Several studies are already available where sustained release dosage forms are developed [13].…”
Section: Sustained Release Drug Deliverymentioning
confidence: 99%
“…Large experimental groups of animals are needed considering the sample volume and number of samples need to be taken for estimation of peak concentration in tissue and time to achieve maximum concentration in tissue. As patient acceptance is less regarding multiple drug dosages, sustained release formulations are being developed [26]. Several studies are already available where sustained release dosage forms are developed [13].…”
Section: Sustained Release Drug Deliverymentioning
confidence: 99%
“…Tumor metastasis leads to the death of patient due to poor response to the treatment. Metastasis greatly changes the genotype of the cancer cells due to multiple mutations leading to more aggressive form [37][38][39][40][41]. It is not easy to track the metastatic cells during the process and further making it difficult to target.…”
Section: Conclusion Natural Compounds In Colon Cancer Migrationmentioning
confidence: 99%
“…Cancer is the biggest threat to mankind due to its aggressive, uncontrollable growth and metastatic properties [22][23][24][25][26]. The first ever anticancer activity of tocotrienols was found by Komiyama et al The research group developed tumor model in mice by injecting cells i.p.…”
Section: Anticancer Activities Of Tocotrienolsmentioning
confidence: 99%