Gender difference in functional properties of Na,K-ATPase in the heart of spontaneously hypertensive rats

Vlkovičová, Jana; Javorková, Veronika; Pecháňová, Oľga; Vrbjar, N

doi:10.1016/j.lfs.2004.10.013

Cited by 19 publications

(10 citation statements)

References 38 publications

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“…Differences between the body weight of male and female SHR and WKY, as well as the differences between strains observed in the present study were similar to those described in the literature [6,7,21-27]. …”

Section: Discussionsupporting

confidence: 91%

Sural nerve involvement in experimental hypertension: morphology and morphometry in male and female normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)

et al. 2012

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BackgroundThe sural nerve has been widely investigated in experimental models of neuropathies but information about its involvement in hypertension was not yet explored. The aim of the present study was to compare the morphological and morphometric aspects of different segments of the sural nerve in male and female spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. Rats aged 20 weeks (N = 6 in each group) were investigated. After arterial pressure and heart rate recordings in anesthetized animals, right and left sural nerves were removed and prepared for epoxy resin embedding and light microscopy. Morphometric analysis was performed with the aid of computer software, and took into consideration the fascicle area and diameter, as well as myelinated fiber number, density, area and diameter.ResultsSignificant differences were observed for the myelinated fiber number and density, comparing different genders of WKY and SHR. Also, significant differences for the morphological (thickening of the endoneural blood vessel walls and lumen reduction) and morphometric (myelinated fibers diameter and G ratio) parameters of myelinated fibers were identified. Morphological exam of the myelinated fibers suggested the presence of a neuropathy due to hypertension in both SHR genders.ConclusionsThese results indicate that hypertension altered important morphometric parameters related to nerve conduction of sural nerve in hypertensive animals. Moreover the comparison between males and females of WKY and SHR allows the conclusion that the morphological and morphometric parameters of sural nerve are not gender related. The morphometric approach confirmed the presence of neuropathy, mainly associated to the small myelinated fibers. In conclusion, the present study collected evidences that the high blood pressure in SHR is affecting the sural nerve myelinated fibers.

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Section: Discussionsupporting

confidence: 91%

Sural nerve involvement in experimental hypertension: morphology and morphometry in male and female normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)

et al. 2012

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“…As expected, both male and female WKY showed lower blood pressure levels than SHR, with no difference between WKY genders, as also reported elsewhere (23).…”

Section: Physiological Datasupporting

confidence: 90%

“…Arterial pressure levels were significantly different between SHR genders as also observed in the literature (14,23), showing that male SHR have higher SAP compared to females. As expected, both male and female WKY showed lower blood pressure levels than SHR, with no difference between WKY genders, as also reported elsewhere (23).…”

Section: Physiological Datasupporting

confidence: 82%

Morphometric analysis of the phrenic nerve in male and female Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)

Rodrigues

Ferreira

Salgado

et al. 2011

Braz J Med Biol Res

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“…The lower I Kr current density in females that reduces the “repolarization reserve” is thought to be of major importance for females' higher sensitivity to I Kr -blocking drugs and their prolonged action potential duration (APD) 5 . Increased activity of cardiac Na + /K + ATPase in female rats 6 that shortens the duration of cardiac repolarization, particularly at fast heart rates, may contribute to the steepening of the QT/RR slope in females. Recently, similar findings of gender differences in cardiac repolarizing ion currents have also been detected in human cardiac tissue derived from non-diseased transplant donors.…”

Section: Cellular Level: Mechanisms Underlying Gender Differences Andmentioning

confidence: 99%

How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity

Odening

Koren

2014

Heart Rhythm

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Gender differences in cardiac repolarization and the arrhythmogenic risk of patients with inherited and acquired long-QT syndromes are well appreciated clinically. Enhancing our knowledge of the mechanisms underlying these differences is critical to improve our therapeutic strategies for preventing sudden cardiac death in such patients. This review summarizes the effects of sex hormones on the expression and function of ion channels that control cardiac cell excitation and repolarization as well as key proteins that regulate Ca2+ dynamics at the cellular level. Moreover, it examines the role of sex hormones in modifying the dynamic spatiotemporal (regional and transmural) heterogeneities in action potential duration (e.g., the arrhythmogenic substrate) and the susceptibility to (sympathetic) triggered activity at the tissue, organ, and whole-animal levels. Finally, it explores the implications of these effects on the management of LQTS patients.

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Gender difference in functional properties of Na,K-ATPase in the heart of spontaneously hypertensive rats

Cited by 19 publications

References 38 publications

Sural nerve involvement in experimental hypertension: morphology and morphometry in male and female normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)

Sural nerve involvement in experimental hypertension: morphology and morphometry in male and female normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)

Morphometric analysis of the phrenic nerve in male and female Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR)

How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity

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