Gender differences in autoimmune disease

Ngo, Shyuan T.; Steyn, Frederik J.; McCombe, Pamela A.

doi:10.1016/j.yfrne.2014.04.004

Cited by 811 publications

(638 citation statements)

References 460 publications

Supporting

Mentioning

587

Contrasting

Unclassified

Order By: Relevance

“…In this cohort there was a wide range of age at diagnosis and a high proportion of females, with the post-surgical being the most frequent etiology of the disease (12,18), agreeing with the literature (5,19,20). The most significant clinical feature was the presence of renal complication in this cohort of patients.…”

Section: Discussionsupporting

confidence: 90%

Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications

Lopes

Kliemann

Bini

et al. 2016

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

Objectives: To identify a clinical profile and laboratory findings of a cohort of hypoparathyroidism patients and determine the prevalence and predictors for renal abnormalities. Materials and methods: Data from medical records of five different visits were obtained, focusing on therapeutic doses of calcium and vitamin D, on laboratory tests and renal ultrasonography (USG). Results: Fiftyfive patients were identified, 42 females and 13 males; mean age of 44.5 and average time of the disease of 11.2 years. The most frequent etiology was post-surgical. Levels of serum calcium and creatinine increased between the first and last visits (p < 0.001 and p < 0.05, respectively); and serum levels of phosphate decreased during the same period (p < 0.001). Out of the 55 patients, 40 had USG, and 10 (25%) presented with kidney calcifications. There was no significant difference in the amount of calcium and vitamin D doses among patients with kidney calcifications and others. No correlation between serum and urinary levels of calcium and the presence of calcification was found. Urinary calcium excretion in 24h was significantly higher in patients with kidney calcification (3.3 mg/kg/d) than in those without calcification (1.8 mg/kg/d) (p < 0.05). Conclusions: The reduction of hypocalcemia and hyperphosphatemia suggest an effectiveness of the treatment, and the increase in serum creatinine demonstrates an impairment of renal function during follow-up. Kidney calcifications were prevalent in this cohort, and higher urinary calcium excretion, even if still within the normal range, was associated with development of calcification. These findings suggest that lower rates of urinary calcium excretion should be aimed for in the management of hypoparathyroidism. Arch Endocrinol Metab. 2016;60(6):532-6

show abstract

Section: Discussionsupporting

confidence: 90%

Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications

Lopes

Kliemann

Bini

et al. 2016

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

show abstract

Section: Pregnancy and The Incidence Of Graves' Diseasementioning

confidence: 99%

“…This gender difference is not universal among autoimmune diseases, and there is little sex difference in the incidence of type 1 diabetes (11). Moreover, anchylosing spondylitis is predominantly affecting men (11). Possibly, the mechanisms involved in the female preponderance of GD may somehow be related to the mechanisms involved in the major changes that occur in the incidence and activity of GD during and after pregnancy.…”

Section: Pregnancy and The Incidence Of Graves' Diseasementioning

confidence: 99%

“…2. Until and including gestational week 6, the nonpregnancy laboratory reference range for TSH can be used; in week 9-12, the lower reference limit of TSH is around 0.1 mU/L (or even below 0.1 mU/L in week [10][11]; and between these time periods, the limit changes from week to week. In the second and third trimester of pregnancy, the non-pregnancy lower reference limit for TSH can be used (37).…”

Section: Changes In Thyroid Function and Test Reference Limits In Prementioning

confidence: 99%

See 1 more Smart Citation

ENDOCRINOLOGY IN PREGNANCY: Pregnancy and the incidence, diagnosing and therapy of Graves’ disease

Laurberg

Andersen

2016

European Journal of Endocrinology

View full text Add to dashboard Cite

Thyroid hormones are essential developmental factors, and Graves' disease (GD) may severely complicate a pregnancy. This review describes how pregnancy changes the risk of developing GD, how early pregnancy by several mechanisms leads to considerable changes in the results of the thyroid function tests used to diagnose hyperthyroidism, and how these changes may complicate the diagnosing of GD. Standard therapy of GD in pregnancy is anti-thyroid drugs. However, new studies have shown considerable risk of birth defects if these drugs are used in specific weeks of early pregnancy, and this should be taken into consideration when planning therapy and control of women who may in the future become pregnant. Early pregnancy is a period of major focus in GD, where pregnancy should be diagnosed as soon as possible, and where important and instant change in therapy may be warranted. Such change may be an immediate stop of anti-thyroid drug therapy in patients with a low risk of rapid relapse of hyperthyroidism, or it may be an immediate shift from methimazole/carbimazole (with risk of severe birth defects) to propylthiouracil (with less risk), or maybe to other types of therapy where no risk of birth defects have been observed. In the second half of pregnancy, an important concern is that not only the mother with GD but also her foetus should have normal thyroid function.Thyroid hormones are essential developmental factors as first shown by Gudernatsch when he, in 1912, fed tadpoles thyroid tissue and observed metamorphosis (1). In mammals, thyroid hormones are especially of importance for brain development (2, 3), and even a few months with lack of thyroid hormones in infant life may lead to irreversible brain damage. This is the background for the universal screening for congenital hypothyroidism performed in many countries. However, thyroid hormones are also important for normal pregnancy, and maternal thyroid disease may severely increase the risk of pregnancy complications, including Invited author's profile Peter Laurberg was Clinical Professor of Internal Medicine and Endocrinology, Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark. His research mainly focused on thyroid disease prevention, epidemiology, diagnosing and therapy, including studies on iodine and thyroid, and pregnancy and thyroid. He had special research interest on the risk from and optimal management of autoimmune hypo-and hyperthyroidism in pregnancy and post-partum, management of Graves' disease in general, and how the burden of thyroid disease can be minimized by adjusting the population's iodine intake. He has coauthored several international guidelines on thyroid disease management, including management of thyrotoxicosis, and thyroid disease in pregnancy. Peter Laurberg died June 20, 2016.

show abstract

“…Az ösztrogénhormonok ezzel összhangban való-színűleg kulcsszerepet játszanak az autoimmun kórké-pek, például az RA, az SLE vagy az SM kialakulásában, ami a nők kiemelt érintettségében mutatkozik meg [4,45].…”

Section: Az öSztrogénmetabolitok Autoimmun Betegségekre Kifejtett Hatunclassified

Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

Kovács

Vásárhelyi

Mészáros³

et al. 2017

Orvosi Hetilap

View full text Add to dashboard Cite

Az ösztrogénhormonok fiziológiai szerepe sok tekintetben ismert. Meglehetősen kevés információ áll azonban rendelkezésre az ösztron és az ösztradiol lebontása során képződő vegyületek szerepéről a különböző, ösztrogénhatással összefüggésbe hozott kórképekben. A kutatások intenzív érdeklődésének középpontjában jelenleg a két ösztrogén-hormon mellett tizenhárom extragonadális metabolit áll. A képződő metabolitok protektív vagy éppen proinflammatorikus és/vagy proonkogén hatással rendelkeznek. A szisztémás keringésben mért metabolitszintek nem mutatnak összefüggést a lokálisan megjelenő metabolitokéval, ennek a jövőben diagnosztikai jelentősége lehet. A jelen tanulmány célja a perifériás szövetekben az extragonadális metabolommal kapcsolatos irodalmi források átfogó áttekintése, valamint felhívni a figyelmet a perifériás szövetek ösztrogénhomeosztázisának szerepére, az ösztrogénmetabolom igazolt, valamint a klasszikus hormonhatásoktól eltérő biológiai aktivitására, egyes kórfolyamatokban azonosított klinikai jelentőségére. Ezek az ismeretek a lokálisan determinált kórfolyamatok megértését, korai diagnosztikáját a későbbiekben a metabolomika eszköztárával jelentősen segíthetik. Orv Hetil. 2017; 158(24): 929-937. Kulcsszavak: ösztrogénmetabolom, perifériás szövetek, emlőkarcinóma, HPLC-MS/MS The biological and clinical relevance of estrogen metabolomeConsiderable knowledge has been gathered on the physiological role of estrogens. However, fairly little information is available on the role of compounds produced in the breakdown process of estrone and estradiol wich may play a role in various diseases associated with estrogen impact. To date, approximately 15 extragonadal estrogen-related compounds have been identified. These metabolites may exert protective, or, instead, pro-inflammatory and/or prooncogenic activity in a tissue-specific manner. Systemic and local estrogen metabolite levels are not necesserily correlated, which may promote the diagnostic significance of the locally produced estrogen metabolites in the future. The aim of the present study is a bibliographic review of the extragonadal metabolome in peripheral tissues, and to highlight the role of the peripheral tissue homeostasis of estrogens as well as the non-hormonal biological activity and clinical significance of the estrogen metabolome.

show abstract

Gender differences in autoimmune disease

Cited by 811 publications

References 460 publications

Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications

Hypoparathyroidism and pseudohypoparathyroidism: etiology, laboratory features and complications

ENDOCRINOLOGY IN PREGNANCY: Pregnancy and the incidence, diagnosing and therapy of Graves’ disease

Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

Contact Info

Product

Resources

About