Gender Differences in Hypertension

Song, Juanjuan; Ma, Zheng; Wang, Juan; Chen, Linxi; Zhong, Jiuchang

doi:10.1007/s12265-019-09888-z

Cited by 160 publications

(134 citation statements)

References 57 publications

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“…The gender‐specific associations found here are similar to the findings of previous studies (Banno et al, ; Funalot et al, ; Funke‐Kaiser et al, ; Song, Ma, Wang, Chen, & Zhong, ). In clinic, Tostes found that the level of ET‐1 in male patients with hypertension was significantly higher than that in females (Tostes et al, ).…”

Section: Discussionsupporting

confidence: 91%

Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study

Wang

Liu

et al. 2020

Molec Gen & Gen Med

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Background:The ECE1 gene polymorphisms have been studied as a candidate gene in essential hypertension, but no consensus has been reached. To systematically explore their possible association, a case-control study was conducted. Methods: This study included 398 hypertensive subjects and 596 healthy volunteers as control subjects in the Northern Han Chinese. A total of 10 tag SNPs of ECE1 gene were genotyped successfully by TaqMan assay. Results: A total of ) were identified as the tag SNPs for ECE1 gene. Although no positive connection has been found in general population, several SNPs have been found to be related to EH risk in genderstratified subgroup analysis. In males, rs115071 T allele influenced EH risk in a protective manner, with dominant model (TT+TC vs. CC: p = .032, OR = 0.655, 95% CI = 0.445-0.965), additive model (TT vs. TC vs. CC: p = .019, OR = 0.616, 95% CI = 0.411-0.924), as well as allele comparison (T vs. C: p = .045, OR = 0.702, 95% CI = 0.496-0.992). While, in females, rs212544 AA genotype would increase the onset risk of EH (recessive model: AA vs. GA+GG, p = .024, OR = 1.847, 95% CI = 1.086-3.142). In the three haplotype blocks identified, rs2076283-rs2236847 C-T haplotype was associated with a decreased risk of EH (OR = 0.558, p = .046). Conclusion:The current case-control study suggested that several SNPs and related haplotypes on ECE1 gene might be associated with the susceptibility of EH in certain gender subgroups in the Northern Han Chinese population. K E Y W O R D Sendothelin converting enzyme-1, essential hypertension, polymorphism, sex difference, the Northern Han Chinese population 2 of 13 | WANG et Al.

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Section: Discussionsupporting

confidence: 91%

Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study

Wang

Liu

et al. 2020

Molec Gen & Gen Med

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“…Specifically, gender had a substantial contribution to the inequality with men having a significantly higher prevalence of inequalities in hypertension than women. Previous studies have observed gender disparities in hypertension [20][21][22], which have been attributed to biological [42] and health behavioural factors [43]. In this study, a further gender-specific decomposition shows that the differences in body mass index, education, employment, and the region could explain the gender disparities in hypertension [Supplementary Table 1].…”

Section: Discussionmentioning

confidence: 57%

Socioeconomic Inequalities in Hypertension in Kenya: A Decomposition Analysis of 2015 Kenya STEPwise Survey on Non-communicable Diseases Risk Factors

Gatimu

John²

2020

Preprint

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IntroductionOne in four Kenyans have raised blood pressure. Despite this high prevalence of hypertension and known association between socioeconomic status and hypertension, there is a paucity of evidence on inequality in raised blood pressure in Kenya. Hence, we quantified the socioeconomic inequality in hypertension in Kenya and decomposed the determinants contributing to such inequality.MethodsWe used data from the 2015 Kenya STEP wise survey for non-communicable diseases risk factors. We included 4,398 respondents aged 18–69 years. We estimated the socioeconomic inequality using the concentration index (C) and decomposed the C using Wag staff decomposition analysis.ResultsThe overall concentration index of hypertension in Kenya was − 0.08 (95% CI: −0.14, − 0.02; p = 0.007), showing socioeconomic inequalities in hypertension disfavouring the poor population. Half (52.8%) of the pro-rich inequalities in hypertension was explained by body mass index (52.8%) while 21.1% by socioeconomic factors (paid employment (9.3%), education (7.7%) and poorest wealth quintile (4.1%)) and 17.6% by demographic factors (female gender (11.8%), age (5.2%) and marital status (0.6%)). Regional differences explained 8.1% of the estimated inequality with the Central region alone explaining 6.9% of the observed inequality. Our model explained 98.3% of the estimated socioeconomic inequality in hypertension in Kenya with a small non-explained part of the inequality (− 0.001).ConclusionThe present study shows substantial socioeconomic inequalities in hypertension in Kenya, mainly explained by metabolic risk factors (body mass index), individual health behaviours, and socioeconomic factors. Kenya needs gender- and equity-focused interventions to curb the rising burden of hypertension and inequalities in hypertension.

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“…However, Class 4 did not include participants with hypertension. Hypertension has been shown to be more prevalent in women [44][45][46]. Therefore, it may be related to the high number of male participants in this class.…”

Section: Discussionmentioning

confidence: 99%

Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study

Katayama

Lee

Bae

et al. 2020

JCM

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This study clarified the patterns of possessing modifiable risk factors of dementia that can be corrected by the elderly who were primarily determined to have mild cognitive impairment (MCI), and then determined the relationship between retention patterns and outcomes from MCI through a 4-year follow-up study. The participants were 789 community-dwelling elders who were ≥65 years old with MCI at baseline. After 4 years, participants were classified into reverters and nonreverters, according to their cognitive function. Repeated measures analysis was performed after imputing missing values due to dropout. Nine modifiable risk factors at baseline were classified by latent class analysis. Subsequently, we performed binomial logistic regression analysis. The reversion rate of 789 participants was 30.9%. The possession patterns of modifiable risk factors among the elderly with MCI were classified into five patterns: low risk, psychosocial, health behavior, educational, and smoking factors. According to logistic regression analysis, the low risk factors class was more likely to recover from MCI to normal cognitive than the other classes (p < 0.05). These results may provide useful information for designing interventions to prevent cognitive decline and dementia in individuals with MCI.

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Gender Differences in Hypertension

Cited by 160 publications

References 57 publications

Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study

Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study

Socioeconomic Inequalities in Hypertension in Kenya: A Decomposition Analysis of 2015 Kenya STEPwise Survey on Non-communicable Diseases Risk Factors

Modifiable Risk Factor Possession Patterns of Dementia in Elderly with MCI: A 4-Year Repeated Measures Study

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