Gender differences in pharmacokinetics of perfluoropentanoic acid using non-linear mixed-effect modeling in rats

Choi, Go-Wun; Choi, Eun-Jeong; Kim, Ju Hee; Kang, Dong Wook; Lee, Yong-Bok; Cho, Hea-Young

doi:10.1007/s00204-020-02705-6

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…Another plausible reason is that short-chain PFASs have a smaller molecular size and therefore diffuse more quickly across the skin layers, thus peaking earlier in the blood, while long-chain PFASs do the opposite. A similar pattern was observed in the H group, except that PFASs peaked earlier (8–48 h, Figure S6a), validating the hypothesis that passive diffusion was at play. − The observed peak times of PFBS and PFPeA in this study were much later than those observed in orally exposed rats, which were as short as 1.0 h and 1.3 h, respectively. , Kim et al documented the peak times of PFOA, PFHxS, and PFOS in orally exposed rats as 1.4, 1.4, and 11.5 h, respectively. D’Eon et al .…”

Section: Resultssupporting

confidence: 85%

“…The unrecovered PFAS mass may have been present in other tissues, such as muscle, gut, and fat, which were not measured in this study. Considering the substantially low tissue-to-plasma partitioning coefficients of PFASs in rat muscle, gut, and brain tissues reported previously (Table S6), ,, we consider that PFAS accumulation in these tissues made a small contribution to the total body burden.…”

Section: Resultsmentioning

confidence: 99%

“…Renal clearance (CL renal , g/h/kg BW) was calculated by dividing the urinary excretion amount (ng/kg BW) by the area under the curve of the blood concentration (AUC 0−144h , (ng• h)/g). 38…”

Section: Discussionmentioning

confidence: 99%

“…62−64 The observed peak times of PFBS and PFPeA in this study were much later than those observed in orally exposed rats, which were as short as 1.0 h and 1.3 h, respectively. 30,38 Kim et al 31 documented the peak times of PFOA, PFHxS, and PFOS in orally exposed rats as 1.4, 1.4, and 11.5 h, respectively. D'Eon et al 22 reported that the peak times of 6:2 and 8:2 diPAP in orally exposed rats were 4.0 and 24.0 h, respectively.…”

Section: Partitioning Of Pfass Into Tissuesmentioning

confidence: 99%

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Insights into the Dermal Absorption, Deposition, and Elimination of Poly- and Perfluoroalkyl Substances in Rats: The Importance of Skin Exposure

Chen

et al. 2022

Environ. Sci. Technol.

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Humans are frequently exposed to poly- and perfluoroalkyl substances (PFASs) via direct skin contact with personal care and consumer products containing them. Here, we used a rat model to estimate the dermal penetration efficiency of 15 representative PFASs. After 144 h post-dosing, 4.1–18.0 and 5.3–15.1% of the applied PFASs in the low (L) and high (H) groups, respectively, were absorbed into the rats. PFAS absorption and permeation were parabolically associated with the perfluorinated carbon chain length (C F), peaking for perfluoroheptanoic acid (PFHpA). The lipid-rich stratum corneum of the skin barrier substantially suppressed the penetration of less hydrophobic short-chain PFASs, whereas the water-rich viable epidermis and dermis served as obstacles to hydrophobic long-chain PFAS permeation. However, the renal clearance (CLrenal) of the target PFAS decreased with increasing C F, suggesting that urinary excretion is crucial to eliminate less hydrophobic short-chain PFASs. Notably, the peak times of PFASs in the systemic circulation of rats (8–72 h) were remarkably longer than those after oral administration (1–24 h). These results suggest that dermal penetration can be long-lasting and contribute considerably to the body burden of PFASs, especially for those with moderate hydrophobicity due to their favorable skin permeation and unfavorable urinary excretion.

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Section: Resultssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Partitioning Of Pfass Into Tissuesmentioning

confidence: 99%

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Insights into the Dermal Absorption, Deposition, and Elimination of Poly- and Perfluoroalkyl Substances in Rats: The Importance of Skin Exposure

Chen

et al. 2022

Environ. Sci. Technol.

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“…Sex has a major impact on lipid (including BA) metabolism, with sex-based differences reported in exposure studies in animal models [16,17].…”

Section: Introductionmentioning

confidence: 99%

Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

Sen

Qadri

Luukkonen

et al. 2022

Journal of Hepatology

168

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Perfluoroalkyl substance exposure is associated with asthma and innate immune cell count in US adolescents stratified by sex

Pan

Guo

Zhou

et al. 2023

Environ Sci Pollut Res

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Gender differences in pharmacokinetics of perfluoropentanoic acid using non-linear mixed-effect modeling in rats

Cited by 7 publications

References 36 publications

Insights into the Dermal Absorption, Deposition, and Elimination of Poly- and Perfluoroalkyl Substances in Rats: The Importance of Skin Exposure

Insights into the Dermal Absorption, Deposition, and Elimination of Poly- and Perfluoroalkyl Substances in Rats: The Importance of Skin Exposure

Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

Perfluoroalkyl substance exposure is associated with asthma and innate immune cell count in US adolescents stratified by sex

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