Gender differences in response to cold pressor test assessed with velocity-encoded cardiovascular magnetic resonance of the coronary sinus

Moro, Pierre-Julien; Flavian, Antonin; Jacquier, Alexis; Kober, Frank; Quilici, Jacques; Gaborit, Bénédicte; Bonnet, Jean‐Louis; Moulin, G.; Cozzone, Patrick J.; Bernard, Monique

doi:10.1186/1532-429x-13-54

Cited by 28 publications

(30 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This discrepancy is probably a result of the differences between measurement of absolute CF values with PET and echocardiographic measurement of CF velocity that has no linear correlation with laminar flow. In fact, previous studies evaluating CF velocity by transthoracic Doppler echocardiography [14,22] or MRI [23] during CPT have found velocity ratios very consistent with the values observed in the present study.…”

Section: Discussionsupporting

confidence: 93%

Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease

Marciano

Galderisi

Gargiulo

et al. 2012

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease

Marciano

Galderisi

Gargiulo

et al. 2012

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

show abstract

“…Interestingly, in response to both CPT trials, the MAP response in females was approximately half that compared with males; an observation that agrees with some (Kilgour & Carvalho, ), but opposes other reports (Moro et al . ). An intriguing finding was the reduction in CCA dilatation observed during both isocapnic and poikilocapnic CPT in females compared with males.…”

Section: Discussionmentioning

confidence: 97%

Cerebrovascular response to the cold pressor test – the critical role of carbon dioxide

Tymko

Kerstens

Wildfong

et al. 2017

Experimental Physiology

View full text Add to dashboard Cite

What is the central question of this study? What is the role of carbon dioxide in the cerebral blood flow (CBF) response to the cold pressor test (CPT)? What is the main finding and its importance? The CBF response was elevated during the isocapnic (controlled CO ) CPT in the middle cerebral artery and the internal carotid artery compared with the poikilocapnic (uncontrolled CO ) CPT, owing to ventilation-associated reductions in end-tidal CO . Furthermore, the common carotid artery vasodilated to a greater extent during the isocapnic compared with the poikilocapnic CPT, whereas the internal carotid artery vasoconstricted during both CPTs. Our data highlight the importance of CO control when investigating the CBF response to the CPT. In addition to increasing sympathetic nervous activity, blood pressure and cerebral blood flow (CBF), the cold pressor test (CPT) stimulates pain receptors, which may increase ventilation above metabolic demand; this response is likely to reduce the partial pressure of end-tidal carbon dioxide (P ET ,CO2) and will attenuate elevations in CBF. Our hypotheses were as follows: (i) the CPT will elicit hyperventilation, effectively lowering P ET ,CO2; (ii) the CBF response will be elevated during an isocapnic (controlled P ET ,CO2) compared with a poikilocapnic CPT (uncontrolled P ET ,CO2); and (iii) in response to the CPT, the common carotid artery (CCA) will vasodilate, while the internal carotid artery (ICA) will remain unchanged to help regulate CBF. Using a new, randomized experimental design, we measured the cerebrovascular response in the middle cerebral artery (MCA), CCA and internal carotid artery (ICA), during an isocapnic and poikilocapnic CPT in 15 participants. Blood pressure and cardiac output (finger photoplethysmography), heart rate (ECG), MCA mean velocity (transcranial Doppler ultrasound) and CCA and ICA CBF (Duplex ultrasound) were recorded during both CPT trials. Our findings were as follows: (i) ventilation increased, which reduced P ET ,CO2 (-5.3 ± 6.4 mmHg) during the poikilocapnic compared with the isocapnic CPT; (ii) the CBF response was elevated during the isocapnic compared with the poikilocapnic CPT in the MCA and ICA, but not in the CCA; and (iii) the CCA dilated to a greater extent during the isocapnic compared with the poikilocapnic CPT, and the ICA vasoconstricted during both trials. Our data emphasize the importance of P ET ,CO2 control in the CBF response to the CPT and in the differential vasomotor regulation between the CCA and ICA.

show abstract

“…For safety reasons, the test was terminated after 4 min (240 s) if the participant had not already removed their hand. The test limit of 4 min was chosen to limit the risk of tissue injury, as supported by the literature [21–23]. …”

Section: Methodsmentioning

confidence: 99%

The Cold Pressor Test as a Predictor of Prolonged Postoperative Pain, a Prospective Cohort Study

2016

View full text Add to dashboard Cite

IntroductionPresently, it is difficult to predict which patients are at increased risk of ongoing pain problems postoperatively. This study followed a group of patients from the week before their operation until 3 months after it, to identify potential risk variables.MethodsFifty-four patients undergoing moderate-major gynaecological surgery at Christchurch Women’s Hospital were recruited and assessed preoperatively over an 11-week period. At this initial assessment, participants were subjected to a cold pressor test (CPT). Telephonic follow-up was conducted at 6 weeks and 3 months postoperatively, to determine pain status. Information regarding the type of operation and surgical approach was collected from hospital records.ResultsPain threshold (time taken to report the onset of pain), as measured by the CPT, was significantly predictive of prolonged pain outcomes (area under the curve = 0.80, 95 % CI 0.66, 0.95). Pain tolerance (total time taken to end the CPT voluntarily) was similarly predictive but non-significant (area under the curve = 0.69, 95 % CI 0.47, 0.90).ConclusionThe preoperative cold pressor test shows some promise for predicting ongoing postoperative pain. However, more research is needed to determine the clinical significance of these findings in larger samples and how they could be incorporated into clinical practice.

show abstract

Gender differences in response to cold pressor test assessed with velocity-encoded cardiovascular magnetic resonance of the coronary sinus

Cited by 28 publications

References 35 publications

Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease

Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease

Cerebrovascular response to the cold pressor test – the critical role of carbon dioxide

The Cold Pressor Test as a Predictor of Prolonged Postoperative Pain, a Prospective Cohort Study

Contact Info

Product

Resources

About