Gender differences in response to abdominal compartment syndrome in rats

Barkai, O.; Assalia, Ahmad; Gleizarov, Evgeny; Mahajna, Ahmad

doi:10.1186/s13104-019-4353-6

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…38 As a limitation of the study, we only investigated male mice, even though some gender differences after blunt AT are likely and have been reported in rats during the development of an abdominal compartment syndrome. 39 Future studies need to also address the organ response in female mice.…”

Section: Discussionmentioning

confidence: 99%

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

et al. 2021

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Abdominal trauma (AT) is of major global importance, particularly with the increased potential for civil, terroristic, and military trauma. The injury pattern and systemic consequences of blunt abdominal injuries are highly variable and frequently underestimated or even missed, and the pathomechanisms remain still poorly understood. Therefore, we investigated the temporal-spatial organ and immune response after a standardized blast-induced blunt AT. Anesthetized mice were exposed to a single blast wave centered on the epigastrium. At 2, 6, or 24 h after trauma, abdominal organ damage was assessed macroscopically, microscopically, and biochemically. A higher degree of trauma severity, determined by a reduction of the distance between the epigastrium and blast inductor, was reflected by a reduced survival rate. The hemodynamic monitoring during the first 120 min after AT revealed a decline in the mean arterial pressure within the first 80 min, whereas the heart rate remained quite stable. AT induced a systemic damage and inflammatory response, evidenced by elevated HMGB-1 and IL-6 plasma levels. The macroscopic injury pattern of the abdominal organs (while complex) was consistent, with the following frequency: liver > pancreas > spleen > left kidney > intestine > right kidney > others > lungs and was reflected by microscopic liver and pancreas damages. Plasma levels of organ dysfunction markers increased during the first 6 h after AT and subsequently declined, indicating an early, temporal impairment of the function on a multi-organ level. The established highly reproducible murine blunt AT, with time-and trauma-severity-dependent organ injury patterns, systemic inflammatory response, and impairment of various organ functions, reflects characteristics of human AT. In the future, thisThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Section: Discussionmentioning

confidence: 99%

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

et al. 2021

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“…In contrast, in the study by Barkai et al (2019), female rats showed greater resistance than male rats, as females demonstrated better preservation of their hemodynamic and metabolic parameters during abdominal compartment syndrome than males did.…”

Section: Discussionmentioning

confidence: 63%

Impact of Glyphosate-Roundup® in the Ileal Structure of Male and Female Rats: A Morphological and Immunohistochemical Study

Saleh

Elghareeb

Atia

et al. 2021

Microscopy and Microanalysis

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The current study was aimed to evaluate the effects of variable doses of the weedicide glyphosate on the ileal (the final section of the small intestine) structure of rats of both sexes, using histological, histochemical, and ultrastructural methods. Forty animals were classified into four groups of 10 animals per group (five males and five females). The first group acted as a control, and the remaining groups were treated with glyphosate-Roundup® 25, 50, and 100 mg/kg body weight daily for 15 days. The results indicated extinct histopathological changes manifested in the deformation of villi, foci of leukocytic infiltration in the core of villi, and hyperplasia of goblet cells. Histochemical examination (Alcian blue and Periodic acid–Schiff stain) revealed a strong positive reaction of goblet cells and an increase in their number in all treated groups. In addition, the immunohistochemical investigation revealed the immunoreactivity of matrix metalloproteinase-9 expression. Furthermore, electron microscopic alternations were represented by the deformation of nuclei, destruction of microvilli, and deposition of lipid droplets. Collectively, the present findings indicate that treatment with glyphosate results in extensive morphological alternations to the ileal structure of rats of both sexes and that female rats are more affected than male rats are.

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“…Reintam-Blaser et al reported a borderline significant association between male sex and IAH among critically ill patients 35 . Additionally, it has been recently described that female rats develop better hemodynamic response after exposure to increased IAP and higher survival than their male counterparts, suggesting a possible role of sex hormones in the hemodynamic adaptation to IAH 38 . Patients that received peritoneal dialysis as renal replacement therapy suffered IAH less commonly when compared to hemodialysis subjects, a finding that has also been described in another transplant cohort 27 .…”

Section: Discussionmentioning

confidence: 99%

Impact of intra-abdominal pressure on early kidney transplant outcomes

Coca

Arias-Cabrales

Pérez‐Sáez

et al. 2022

Sci Rep

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Increased intra-abdominal pressure (IAP) is common among post-surgical patients and may cause organ dysfunction. However, its impact after kidney transplantation on early postoperative complications and graft recovery remains unclear. We designed a prospective, observational cohort study to describe the prevalence and determinants of IAP, as well as its effect on delayed graft function, postoperative complications, and graft recovery. IAP was measured in 205 kidney transplant recipients every 8 h during the first 72 h after surgery using the urinary bladder technique. Intra-abdominal hypertension was defined as IAP ≥ 12 mmHg. Patients were followed for 6 months or until graft failure/death. Mean IAP was 12 ± 3.3 mmHg within the first 24 h. 78% of subjects presented with intra-abdominal hypertension during the first 72 h. Increased IAP was associated with higher renal resistive index [r = 0.213; P = 0.003] and lower urine output [r = − 0.237; P < 0.001]. 72 h mean IAP was an independent risk factor for delayed graft function [OR: 1.31; 95% CI: 1.13–1.51], postoperative complications [OR: 1.17; 95% CI: 1.03–1.33], and absence of graft function recovery [HR for graft function recovery: 0.94; 95% CI: 0.88–0.99]. Increased IAP was highly prevalent after transplantation and was independently associated with delayed graft function, postoperative complications, and absence of graft function recovery. Routine IAP monitoring should be considered post-transplantation to facilitate early recognition of relevant complications.

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Gender differences in response to abdominal compartment syndrome in rats

Cited by 4 publications

References 30 publications

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

Temporal–spatial organ response after blast‐induced experimental blunt abdominal trauma

Impact of Glyphosate-Roundup® in the Ileal Structure of Male and Female Rats: A Morphological and Immunohistochemical Study

Impact of intra-abdominal pressure on early kidney transplant outcomes

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