Gender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbons

Dosemeci, Mustafa; Cocco, Pierluigi; Chow, Wong Ho

doi:10.1002/(sici)1097-0274(199907)36:1<54::aid-ajim8>3.0.co;2-0

Cited by 67 publications

(41 citation statements)

References 45 publications

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“…It may, in part, reflect differences in exposures between biomarker studies (generally < 40 ppm) (18,24) and subjects in this study (66) who experienced narcotic symptoms, which can occur only at much higher exposure levels [e.g., 200 mL/m3, Stopps (106)]. These findings are also supported by the results of Dosemeci et al (68).…”

Section: Community-based Studiessupporting

confidence: 81%

“…Some studies use job titles to infer exposure (60,63,67), one compares dry cleaning workers to laundry workers (59), others assess risk to subjects exposed to general classes of solvents (57,63), and still other studies ask about exposure to specific agents or used more sophisticated exposure characterizations ( Elevated odds ratios for kidney cancer are found for four different exposure classifications: degreasing agents (including TCE ) (60,61,66), solvents (61,63,65), the iron/ steel industry (likely including exposure to degreasing agents or solvents) (58,(62)(63)(64)(65), and dry cleaners/laundry workers (60,64,65). A few studies assesses TCE exposure specifically (66,68,84 (66), is hospitalbased using accident victims as controls. The study was conducted in an area of Germany containing a large number of metal-working shops using TCE for degreasing purposes.…”

Section: Community-based Studiesmentioning

confidence: 99%

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Trichloroethylene and cancer: epidemiologic evidence.

Wartenberg

Reyner

Scott

2000

Environ Health Perspect

203

156

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Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to trichloroethylene. Evidence of excess cancer incidence among occupational cohorts with the most rigorous exposure assessment is found for kidney cancer (relative risk lRR] = 1.7, 95% confidence interval [Cl] 1.1-2.7), liver cancer (RR = 1.9, 95% Cl 1.0-3.4), and non-Hodgkin's lymphoma (RR = 1.5, 95% Cl 0.9-2.3) as well as for cervical cancer, Hodgkin's disease, and multiple myeloma. However, since few studies isolate trichloroethylene exposure, results are likely confounded by exposure to other solvents and other risk factors. Although we believe that solvent exposure causes cancer in humans and that trichloroethylene likely is one of the active agents, we recommend further study to better specify the specific agents that confer this risk and to estimate the magnitude of that risk.

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Section: Community-based Studiessupporting

confidence: 81%

Section: Community-based Studiesmentioning

confidence: 99%

Trichloroethylene and cancer: epidemiologic evidence.

Wartenberg

Reyner

Scott

2000

Environ Health Perspect

203

156

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“…While the pattern of the results observed for some cancers differed somewhat between the men and women, the hypothesis of homogeneity was not formally rejected for any cancer. The low power of the statistical tests of heterogeneity may explain why the results of the men and women did not appear to be heterogeneous, while differences in the exposure circumstances of the men and women holding the same job title may explain the observed differences (15). Our present study overlapped somewhat with two previous studies in which the results concerning dry cleaners were reported as part of a systematic review of occupation-cancer associations (16,17).…”

Section: Discussionsupporting

confidence: 53%

“…The evidence of an association between TCE or PCE exposure and kidney cancer is inconclusive (29). At least in one study, however, an increased risk of renal cell cancer was associated with TCE exposure among women, but not among men (15). It is also possible that the association observed in our study may have been due to occupational exposures other than solvents, as the risk was highest for female dry cleaners, launderers, and pressers employed in industries other than laundry, ironing, and dyeing.…”

Section: Discussionmentioning

confidence: 99%

Cancer incidence of dry cleaning, laundry and ironing workers in Sweden

Travier¹,

Gridley²,

Roos³

et al. 2002

Scand J Work Environ Health

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“…Renal cell carcinoma (RCC) is the most common kidney tumor, whose incidence and mortality increases continuously over the past 30 years (1,2). Although surgical intervention is effective for the majority of patients with a localized disease, approximately 30% of patients are diagnosed with metastatic diseases initially (3).…”

Section: Introductionmentioning

confidence: 99%

Tpl2 Kinase Impacts Tumor Growth and Metastasis of Clear Cell Renal Cell Carcinoma

Lee

Joo

Lim

et al. 2013

Molecular Cancer Research

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Due to the innate high metastatic ability of renal cell carcinoma (RCC), many patients with RCC experience local or systemic relapses after surgical resection. A deeper understanding of the molecular pathogenesis underlying advanced RCC is essential for novel innovative therapeutics. Tumor progression locus 2 (Tpl2), upregulated in various tumor types, has been reported to be associated with oncogenesis and metastatic progression via activation of the MAPK signaling pathway. Herein, the relevance of Tpl2 in tumor growth and metastasis of RCC is explored. Inspection of The Cancer Genome Atlas (TCGA) indicated that Tpl2 overexpression was significantly related to the presence of metastases and poor outcome in clear cell RCC (ccRCC), which is the most aggressive subtype of RCC. Moreover, expression of Tpl2 and CXCR4 showed a positive correlation in ccRCC patients. Depletion of Tpl2 by RNAi or activity by a Tpl2 kinase inhibitor in human ccRCC cells remarkably suppressed MAPK pathways and impaired in vitro cell proliferation, clonogenicity, anoikis resistance, migration, and invasion capabilities. Similarly, orthotopic xenograft growth and lung metastasis were significantly inhibited by Tpl2 silencing. Furthermore, Tpl2 knockdown reduced CXCL12-directed chemotaxis and chemoinvasion accompanied with impaired downstream signaling, indicating potential involvement of Tpl2 in CXCR4-mediated metastasis. Taken together, these data indicate that Tpl2 kinase is associated with and contributes to disease progression of ccRCC.

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Gender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbons

Cited by 67 publications

References 45 publications

Trichloroethylene and cancer: epidemiologic evidence.

Trichloroethylene and cancer: epidemiologic evidence.

Cancer incidence of dry cleaning, laundry and ironing workers in Sweden

Tpl2 Kinase Impacts Tumor Growth and Metastasis of Clear Cell Renal Cell Carcinoma

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