Gender Differences in Suicidal Behavior in Korea

Hur, Ji-Won; Lee, Bun Hee; Lee, Sung Woo; Shim, Se-Hoon; Han, Sang Woo; Kim, Yong Ku

doi:10.4306/pi.2008.5.1.28

Cited by 18 publications

(9 citation statements)

References 34 publications

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“…Indeed, a number of studies have used this scale in Korea. [38][39][40] We hope that the relationship between the rs6265 polymorphism and the lethality of suicide attempts described in this study will be useful for predicting serious suicide risk in future clinical practice. However, to apply the results of this study to clinical practice, replication studies on more subjects, including healthy controls, are needed.…”

Section: Discussionmentioning

confidence: 91%

The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population

Kang

Lee

et al. 2020

Psychiatry Investig

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Suicide is one of the most serious health and social problems and is a worldwide phenomenon. According to statistics from 2017, the suicide rate in South Korea was 24.3 per 100,000 individuals. 1 Although South Korea is a country with a declining suicide rate, its rate is still one of the highest among the Organization for Economic Cooperation and Development countries. Since the most important prevention is the early detection of groups at high risk for suicide, many studies and efforts to find high-risk groups have been steadily carried out, and many ge- Print ISSN 1738-3684 / On-line ISSN 1976 OPEN ACCESS netic studies have been conducted to identify candidate genes for suicidal behavior. Many studies on genetic associations have suggested that several genes, such as those encoding serotonin receptors and transporters, tryptophan hydroxylase, and brainderived neurotrophic factors (BDNFs), are related to suicidal behavior; however, these findings have not been consistently replicated. 2 BDNF is a neurotrophic factor involved in the development and maintenance of neural cells 3 and is important for cell survival and apoptosis in neural cells. 4 Substantial evidence has shown that the BDNF gene has a connection with the genetic etiology of psychiatric disorders and suicidal behavior. 5 Postmortem studies have shown reduced BDNF expression in suicide victims, 6 and major depressive disorder patients who attempted suicide have shown decreased plasma levels of BDNF. 7 BDNF is encoded by the BDNF gene located on chromosome 11, 8 and most genetic association studies between this gene and suicidal behavior were performed for the rs6265 polymorphism, which is also known as the Val66Met or G196A poly-Objective Since the risk of suicide cannot be predicted by clinical symptoms alone, and suicide is known to have a genetic component, the discovery of genetic markers that can predict the lethality of suicide attempts is a clinically important topic. There have been many studies aiming to determine whether the rs6265 polymorphism of the BDNF gene is associated with suicidality; however, the results have been mixed, and there have been few studies investigating the relationship between this polymorphism and suicide attempt lethality. Methods We assessed suicide lethality in 258 individuals who had attempted suicide using the relative risk ratio (RRR) scale and by genotyping the rs6265 polymorphism of the BDNF gene. Results The RRR score for suicide attempts was higher in subjects with Met/Val and Val/Val genotypes than in that with a Met/Met genotype (p=0.015). The RRR score for suicide attempts was also higher in Val allele carriers (Met/Val+Val/Val) than in Met/Met homozygotes (p=0.006). Conclusion This study demonstrates the possibility that the rs6265 polymorphism of the BDNF gene could be used as a genetic marker to predict the lethality of suicide attempts, but more replication studies are needed for the application of this result in clinical practice. Psychiatry Investig 2020;17(5):417-423cc This is an Open Access arti...

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Section: Discussionmentioning

confidence: 91%

The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population

Kang

Lee

et al. 2020

Psychiatry Investig

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“…[ 43 ] Compared to men, women report more suicidal thoughts but do not act on thoughts (low suicidal attempt). [ 44 ] Most studies, however, have focused on the main effects of gender on suicidality,[ 45 46 47 ] and our knowledge is very limited on the moderating effect of intersection of gender and ethnicity on factors that contribute to suicide. [ 48 ]…”

Section: Discussionmentioning

confidence: 99%

Ethnic and gender differences in additive effects of socio-economics, psychiatric disorders, and subjective religiosity on suicidal ideation among blacks

Assari

2015

Int J Prev Med

134

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Background:This study aimed to investigate the additive effects of socio-economic factors, number of psychiatric disorders, and religiosity on suicidal ideation among Blacks, based on the intersection of ethnicity and gender.Methods:With a cross-sectional design, data came from the National Survey of American Life, 2001–2003, which included 3570 African-American and 1621 Caribbean Black adults. Socio-demographics, perceived religiosity, number of lifetime psychiatric disorders and lifetime suicidal ideation were measured. Logistic regressions were fitted specific to groups based on the intersection of gender and ethnicity, while socioeconomics, number of life time psychiatric disorders, and subjective religiosity were independent variables, and lifetime serious suicidal ideation was the dependent variable.Results:Irrespective of ethnicity and gender, number of lifetime psychiatric disorders was a risk factor for lifetime suicidal ideation (odds ratio [OR] ranging from 2.4 for Caribbean Black women to 6.0 for Caribbean Black men). Only among African-American men (OR = 0.8, 95% confidence interval = 0.7–0.9), perceived religiosity had a residual protective effect against suicidal ideation above and beyond number of lifetime psychiatric disorders. The direction of the effect of education on suicidal ideating also varied based on the group.Conclusions:Residual protective effect of subjective religiosity in the presence of psychiatric disorders on suicidal ideation among Blacks depends on ethnicity and gender. African-American men with multiple psychiatric disorders and low religiosity are at very high risk for suicidal ideation.

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“…En comparación con la prevalencia de ideación suicida después de terremotos dada en otros estudios (Chen et al, 2001;Vehid et al, 2006;), la encontrada aquí fue levemente menor. Respecto de la prevalencia de ideación suicida según el sexo, no se detectó una mayor prevalencia entre las mujeres como lo plantean otras investigaciones (Hur et al, 2008;Sarmiento Silva & Aguilar Villalobos, 2011). Esto parece indicar que la condición de ser o no mujer no estaría a la base de la ideación.…”

Section: Discusión Y Conclusionesunclassified

Ideación suicida y estrés postraumático después del terremoto y tsunami del 27-F

2017

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Este estudio identifica la prevalencia de ideación suicida y su relación con el trastorno de estrés postraumático (TEPT) en personas afectadas por el terremoto y tsunami del 27 de febrero de 2010 en Chile. Se aplicó a 247 participantes la Escala de Trauma de Davidson y un ítem del instrumento SPRINT-E que mide ideación suicida. Se encontró un 8,9% de prevalencia de ideación suicida, mientras que el 4,9% presenta ideación suicida y TEPT con una pauta de asociación importante (rtc = 4,4; CC = ,267). Además, desempeñarse como ama de casa, tener un familiar afectado por el desastre, y tener TEPT son los principales factores de riesgo para la ideación suicida. Se recomienda a la red de salud tenerlos presentes a la hora de evaluar e intervenir poblaciones afectadas por desastres.

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Gender Differences in Suicidal Behavior in Korea

Cited by 18 publications

References 34 publications

The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population

The rs6265 Polymorphism of the BDNF Gene Is Related to Higher-Lethality Suicide Attempts in the Korean Population

Ethnic and gender differences in additive effects of socio-economics, psychiatric disorders, and subjective religiosity on suicidal ideation among blacks

Ideación suicida y estrés postraumático después del terremoto y tsunami del 27-F

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