Gender differences in the dihydropyrimidine dehydrogenase expression of colorectal cancers

Yamashita, Kazuki; Mikami, Yoshiko; Ikeda, Masaharu; Yamamura, Masahiko; Kubozoe, Tadahiko; Urakami, Atsushi; Yoshida, Kazuhiro; Kimoto, Masatoshi; Tsunoda, Tsukasa

doi:10.1016/s0304-3835(02)00435-4

Cited by 30 publications

(15 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our series, the DPD protein level in CRC was lower in women than in men, consistent with the results of Yamashita et al [13] , who found that colonic tumors were more common in women than in men, whereas protein expression levels of DPD in both colonic and rectal tumors were lower in women. In the present study, the DPD protein expression level was significantly lower in colonic tumors than in rectal tumors, but there was no significant gender-related difference in the location of primary tumors (data not shown).…”

Section: Discussionsupporting

confidence: 92%

“…When the tumors in our series were classified according to histopathological type, DPD levels in poorly differentiated, mucinous and signet ring cell tumors were significantly higher than those in well-and moderately differentiated tumors. In contrast, Yamashita et al [13] and Shirota et al [16] demonstrated no significant difference in DPD protein or mRNA expression levels according to histopathological type in CRC. In primary gastric cancer, Ichikawa et al [17] reported that TS and DPD mRNA expression levels differ according to the degree of tumor differentiation.…”

Section: Discussionmentioning

confidence: 89%

See 1 more Smart Citation

Correlations of Clinicopathological Factors with Protein Expression Levels of Thymidylate Synthase, Dihydropyrimidine Dehydrogenase and Orotate Phosphoribosyltransferase in Colorectal Cancer

Sumi

Katsumata²,

Tsuchida³

et al. 2010

Chemotherapy

View full text Add to dashboard Cite

Background: Expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and orotate phosphoribosyltransferase (OPRT) have been reported to be associated with tumor response to 5-fluorouracil (5-FU). Method: We investigated correlations of clinicopathological factors with protein expression levels of TS, DPD, OPRT in colorectal cancer (CRC). The subjects were 202 patients who had undergone CRC resection. Result: There was a negative correlation between DPD and OPRT protein levels, but no correlation of TS levels with either OPRT or DPD levels. The DPD levels in women was significantly lower than that in men. The DPD level was significantly lower in colonic tumors than in rectal tumors, while the OPRT level was significantly higher in colonic tumors than in rectal tumors. The TS level did not correlate with any clinicopathological factors. Conclusion: DPD and OPRT protein levels in CRC suggest that female gender and colonic tumors are positive prognostic factors in patients who receive chemotherapy with 5-FU.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 89%

Correlations of Clinicopathological Factors with Protein Expression Levels of Thymidylate Synthase, Dihydropyrimidine Dehydrogenase and Orotate Phosphoribosyltransferase in Colorectal Cancer

Sumi

Katsumata²,

Tsuchida³

et al. 2010

Chemotherapy

View full text Add to dashboard Cite

show abstract

“…However, there were no significant differences in treatment-related deaths according to BMI class (P ϭ 0.99). Although reports of differences in 5-FU toxicity according to patient gender have been reported, 38 the differences in treatment-related toxicity according to BMI class were similar for both men and women.…”

Section: Treatment-related Toxicity By Body Mass Index Classmentioning

confidence: 74%

Influence of body mass index on outcomes and treatment‐related toxicity in patients with colon carcinoma

Meyerhardt

Catalano

Mayer

et al. 2003

Cancer

280

198

View full text Add to dashboard Cite

A current focus in the energy field is on the use of hydrogen in fuel cells. Development of a hydrogen station system is important to the commercialization of fuel cells and fuel cell powered vehicles. In this study, the heat‐exchange pressure swing adsorption (HE‐PSA) was developed to design a compact H2 PSA process for small spatial occupancy in the hydrogen station. The adsorption dynamics and performance of the newly designed bed were compared with those of a conventional bed by using a quaternary mixture (H2/CO2/CH4/CO 69:26:3:2 vol %) which is generally obtained from the steam‐reforming reaction of natural gas. Because the detrimental exothermic/endothermic heat effects accompanied by the adsorption/desorption steps were reduced by heat exchange between the adsorption beds, the separation performance of the HE‐PSA was higher than that of a conventional PSA. In addition, the spatial occupancy of the beds could be significantly reduced, compared with a conventional PSA, because the single annular‐type bed performed the function of two beds in the HE‐PSA. © 2008 American Institute of Chemical Engineers AIChE J, 2008

show abstract

“…Bei Frauen wurde im Tumorgewebe deutlich weniger DPD exprimiert, verglichen mit den Gewebeproben aus der gesunden Darmwand (p = 0,0002). Frauen sprechen deshalb wahrscheinlich besser auf die Therapie mit 5-FU an als Männer, die keinen Unterschied in der DPD-Expression aufwiesen [53]. Andererseits ist bei erhöhter Bioverfügbarkeit von 5-FU an eine mögliche Kardiotoxizität zu denken.…”

Section: Rezidivrate Und Rezidivmusterunclassified

Genderaspekte bei Tumoren des Gastrointestinaltrakts und ihre Prognose, insbesondere im Rahmen multimodaler Therapiekonzepte

et al. 2015

View full text Add to dashboard Cite

Systematic analyses of gender effects in gastrointestinal malignancies are currently lacking, partly because sex and gender have not been used as stratification criteria in major studies on the topic. It is, however, indisputable that gastrointestinal tumours differ in risk factors, incidence and prognosis between the genders. This review summarises the most important findings on differences related to biological sex and sociocultural gender and discusses anatomic specifics with immediate significance for surgical interventions. Epidemiological differences in upper gastrointestinal malignancies are most prominent in regard to histological subtypes, directly affecting diagnostics, therapy, and prognosis. Women have a better prognosis in many of these tumour subtypes. For colorectal carcinoma, sex hormones, specifically oestrogens, appear to play a distinct role in tumourigenesis. Histopathological analysis of the expression of oestrogen receptor beta (ERβ) in the tumour tissue has attracted interest since it was shown that women with low ERβ expression have a better prognosis than men with comparable ERβ status. Data on the higher incidence of right-sided colon carcinoma and non-polypoid neoplasms in women could lead to improved screening programmes. Men and women cite differing reasons for avoidance of screening colonoscopies, thus gender specific approaches could improve colon cancer prevention programmes. Data on differing bioavailability of 5-fluorouracil between the genders are useful to minimise adverse effects of chemotherapy and should be accounted for in dosage. Further systematic analysis of gender effects on gastrointestinal tumours is warranted and would be a substantial step towards personalised oncological surgery.

show abstract

Gender differences in the dihydropyrimidine dehydrogenase expression of colorectal cancers

Cited by 30 publications

References 15 publications

Correlations of Clinicopathological Factors with Protein Expression Levels of Thymidylate Synthase, Dihydropyrimidine Dehydrogenase and Orotate Phosphoribosyltransferase in Colorectal Cancer

Correlations of Clinicopathological Factors with Protein Expression Levels of Thymidylate Synthase, Dihydropyrimidine Dehydrogenase and Orotate Phosphoribosyltransferase in Colorectal Cancer

Influence of body mass index on outcomes and treatment‐related toxicity in patients with colon carcinoma

Genderaspekte bei Tumoren des Gastrointestinaltrakts und ihre Prognose, insbesondere im Rahmen multimodaler Therapiekonzepte

Contact Info

Product

Resources

About