Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada)

Abdelouahab, Nadia; Mergler, Donna; Takser, Larissa; Vanier, Claire; St-Jean, Mélissa; Baldwin, Mary; Spear, Philip A.; Chan, Hing Man

doi:10.1016/j.envres.2008.01.006

Cited by 110 publications

(76 citation statements)

References 86 publications

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“…Both in vivo and in vitro HgCl 2 treatment showed high rate of progesterone synthesis and low rate of conversion to 17β-Estradiol in the oocytes of Channa punctatus. Besides this Hg was also shown to cause reduction in sperm motility and sperm count (Chowdhury & Arora, 1982) and increase in plasma levels of T 4 , TSH, Estrone and Estradiol (Abdelouahaba et al, 2008). Thus, in the present study, we showed that heavy metals can differentially modulate catfish oocyte maturation, ovulation.…”

Section: Discussionmentioning

confidence: 49%

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Gautam¹,

Chaube²

2018

Turk. J. Fish. Aquat. Sci.

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The aim of the present study was to examine comparative effects of different concentrations of heavy metals such as cadmium (Cd), cobalt (Co), lead (Pb) and mercury (Hg) on catfish oocyte maturation and ovulation. Post-vitellogenic oocytes of the catfish H. fossilis were incubated with heavy metals at concentrations of 0.1, 1.0, 10 and 50ng/ml. Translucent follicles without germinal vesicle and opaque follicles with GV were scored after 4, 8, 16, and 24 hr of incubation. Percentage GV breakdown (GVBD) was calculated as an index of oocyte maturation. The results of present investigation suggested that the effect of heavy metals on oocyte maturation and ovulation was in the order of Pb > Hg >Cd>Co. Pb and Hg showed significant increases (P<0.05) in GVBD and ovulation at all concentrations during 4 and 8hr of the incubation. However, there was a dose -dependent decrease at 16 and 24hr. Cd and Co showed decline in GVBD and ovulation at 16 and 24 hr of the incubation. However, mercury and lead showed a stimulatory effect on ovulation at 16 and 24 hr compared to control (P<0.05). Thus, these results suggest that catfish oocytes are differentially influenced by heavy metals and are resistant to them at certain levels.

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Section: Discussionmentioning

confidence: 49%

Untitled

Gautam¹,

Chaube²

2018

Turk. J. Fish. Aquat. Sci.

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“…A recent systematic review suggested genderrelated differences in the susceptibility to metals, with boys generally more susceptible than girls (Llop et al 2013). Moreover, some authors found that metals such as lead, mercury, and cadmium have the ability to interfere with physiological thyroid hormone levels (Iijima et al 2007;Abdelouahab et al 2008). Additionally, metals may have sex-specific effects on social behavior by interacting with central dopamine function (Curtis et al 2010).…”

Section: Discussionmentioning

confidence: 99%

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Gorini

Muratori

Morales

2014

Rev J Autism Dev Disord

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An increasing evidence supports the role of industrial chemicals as contributors to the development of neurobehavioral disorders, including autism spectrum disorders, whose prevalence has progressively increased in recent years. Heavy metals, in particular, are recognized as neurodevelopmental toxins since they can be responsible of fetal damages which lead to neurological defects, developmental delays, learning disabilities and behavioral abnormalities. Most of the reviewed studies reported a relationship between exposure to metals during perinatal and early childhood periods and increased risk for autism. Moreover, the effects resulting from co-exposure to multiple metals should not be underestimated, especially in the assessment of children who live in developing countries or near heavily contaminated sites.

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“…Our earlier studies on the perinatal exposure to PCBs in rats demonstrated sex-dependent effects on cerebellar and motor functions with males being more sensitive (Nguon et al, 2005b). Even at low concentrations, different PCB congeners interfere with TH status in a sex-dependent manner (Abdelouahab et al, 2008). Our recently completed study on the perinatal exposure to TM revealed not only sex-but also strain-dependent effects on motor learning and cerebellar oxidative stress and D2 activity (Sulkowski et al, accepted).…”

Section: Sexually Dimorphic Responses To Environmental Endocrine Disrmentioning

confidence: 99%

Environmentally Induced Oxidative Stress and Disruption of Brain Thyroid Hormone Homeostasis in Autism Spectrum Disorders

Sajdel-Sulkowska¹

2011

Autism - A Neurodevelopmental Journey From Genes to Behaviour

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Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada)

Cited by 110 publications

References 86 publications

Untitled

Untitled

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Environmentally Induced Oxidative Stress and Disruption of Brain Thyroid Hormone Homeostasis in Autism Spectrum Disorders

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