Gender effect on prognosis of patients receiving long-term home oxygen therapy. The Respiratory Failure Research Group in Japan.

Miyamoto, Kenji; Aida, Akira; Nishimura, Masaharu; Aiba, Miyoji; Kira, Shiro; Kawakami, Yoshikazu

doi:10.1164/ajrccm.152.3.7663812

Cited by 86 publications

(47 citation statements)

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“…A Japanese study of patients treated with LTOT for COPD, tuberculosis sequelae, or interstitial pneumonia showed significantly better survival in women, despite a higher average baseline Pa CO 2 (see Figure E1) (52). This finding was confirmed in a meta-analysis of LTOT in which a survival advantage also existed for women (53).…”

Section: Therapeutic Implicationsmentioning

confidence: 78%

Gender and Chronic Obstructive Pulmonary Disease

Han¹,

Postma²,

Mannino³

et al. 2007

Am J Respir Crit Care Med

307

224

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5Pulmonary and Critical Care Section, Veterans Affairs Health System, Ann Arbor, MichiganThe prevalence of chronic obstructive pulmonary disease (COPD) in women is increasing, as is hospitalization for COPD. The number of women dying of COPD in the United States now surpasses men. Despite this, research suggests that physicians are still more likely to correctly diagnose men with COPD than women. Increased tobacco use in women likely explains some of the increase in the prevalence of COPD in women, but data suggest that women may actually be at greater risk of smoking-induced lung function impairment, more severe dyspnea, and poorer health status for the same level of tobacco exposure. The degree to which these observations represent biologic, physiologic, or sociologic differences is not known. Nonsmokers with COPD are also more likely to be female. In addition, new evidence is emerging that men and women may be phenotypically different in their response to tobacco smoke, with men being more prone to an emphysematous phenotype and women an airway predominant phenotype. Inasmuch as COPD is a disease of inflammation, it is also possible that sexual dimorphism of the human immune response may also be responsible for gender differences in the disease. More data are still needed on what the implications of these findings are on therapy. In this clinical commentary, we present current knowledge regarding how gender influences the epidemiology, diagnosis, and presentation of COPD in addition to physiologic and psychologic impairments and we attempt to offer insight into why these differences might exist and how this may influence therapeutic management.

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Section: Therapeutic Implicationsmentioning

confidence: 78%

Gender and Chronic Obstructive Pulmonary Disease

Han¹,

Postma²,

Mannino³

et al. 2007

Am J Respir Crit Care Med

307

224

View full text Add to dashboard Cite

show abstract

“…Gender differences: These differences for COPD survival prognosis have been reported repeatedly but remain controversial 8,[31][32][33] . Some have reported that women have better survival 8,31,32 , but others describe contradictory findings 33 .…”

Section: Components Of Copd Prognostic Scorementioning

confidence: 99%

“…Some have reported that women have better survival 8,31,32 , but others describe contradictory findings 33 . We hypothesize that it is difficult to adjust all coverable parameters in multiple-variable analysis when comparing both sexes because the two sexes have different FEV 1 predicting formulas and different reference values for exercise tolerance tests.…”

Section: Components Of Copd Prognostic Scorementioning

confidence: 99%

Chronic obstructive pulmonary disease prognostic score: A new index

Horita¹,

Koblížek²,

Plutinsky³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. The evaluation of chronic obstructive pulmonary disease (COPD) has been shifting from spirometry to focus on the patients' overall health. Despite the existence of many COPD prognostic scales, there remains a large gap for improvement, in particular a scale that incorporates the current focus on overall health. Methods. We proposed a new prognostic scale (the COPD Prognostic Score) through discussion among the authors based on published studies. Validation was retrospective, using data from the National Emphysema Treatment Trial. Results. The scores ranged from 0-16, where 16 indicated the poorest prognosis. We assigned 4 points each for forced expiratory volume in one second (%predicted), the modified Medical Research Council dyspnea scale, and age; 2 points for the hemoglobin level; and one point each for decreased activity and respiratory emergency admission in the last two years. The validation cohort included 607 patients and consisted of 388 men (73.9%) and 219 women (36.1%), mean age 67 ± 6 years and an average forced expiratory volume in one second (% predicted) of 27 ± 7%. A one-point increase in the score was associated with increased all-cause death, with a hazard ratio of 1.28 (95%CI: 1.21-1.36. P < 0.001). The areas under the receiver operating characteristic curves for two-year and five-year all-cause death for the new scale were 0.72 and 0.66, respectively. These values were higher than those given by the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index and age, dyspnea, airway obstruction (ADO) index. Conclusion. The preliminary validation for a new COPD prognostic scale: the COPD Prognostic Score was developed with promising results thus far. Above mentioned 16-point score accurately predicted 2-year and 5-year all-cause mortality among subjects who suffered from severe and very severe COPD.

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“…Bu durumun cinsiyetler arasında sigara tüketim oranındaki ve sigaranın olumsuz etkilerine olan duyarlılıktaki farklılıklardan kaynaklanabileceği düşünülmektedir (6). Kadın KOAH hastalarında hastalığın seyrinin daha iyi olduğunu ifade eden çalışma sonuçlarının yanı sıra, (3,7); kadınlarda atak sayısının ve dispne skorlarının daha yüksek, yaşam kalitesi skorlarının daha düşük, (4); hastalık şiddeti (8), hastaneye yatış sıklığı (6) ve mortalite oranlarının (9) daha yüksek olduğunu gösteren çalışma sonuçları da bulunmaktadır.…”

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Effects of Gender on Physical, Physiological, and Clinical Characteristics in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Yağlı¹,

Sağlam²,

İnce³

et al. 2015

Yoğun Bakim Derg

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Objective: Differences can be observed between genders in chronic obstructive pulmonary disease (COPD) arising from clinical, perceptual, and structural factors. The purpose of this study was to investigate the effects of gender on physical and physiological characteristics in acute exacerbation of COPD.Material and Methods: Seventy-one patients with acute exacerbation of COPD (44 males, 27 females) participated in this study. Physical and demographical characteristics, vital signs, admission findings, comorbidities, arterial blood gas values, and chest radiography findings were recorded. Level of consciousness was determined using the Glasgow coma scale. Acute Physiology and Chronic Health Evaluation II (APACHE II) score, acute physiology score, Charlson Comorbidity Index score, and Ottawa COPD Risk Scale score were calculated. Functional level was determined using the Functional Status Scale. Exercise capacity was analyzed. Treatments conducted for the subjects (medical treatment, respiratory support, and physiotherapy) were recorded.Results: Male and female subjects with acute exacerbation of COPD were similar in terms of age, signs and symptoms, chest radiography findings, exercise capacity, Charlson Comorbidity Index score, and Ottawa COPD Risk Scale score (p>0.05). Females' body mass index, APACHE II score, acute physiology score were significantly higher than those of males (p<0.05). The smoking history was significantly higher and functional capacity was lower in male subjects than in females (p<0.05). There were no significant differences in medical treatment, respiratory support, physiotherapy applications, and length of hospital stay between males and females (p>0.05) Conclusion: Male and female patients with acute exacerbation of COPD had physical, physiological, and clinical differences. Smoking history was low, and their participation in daily life activities was less impaired. Physiotherapy applications and other treatments performed were similar between females and males, despite a higher disease severity in females. (Yoğun Bakım Derg 2015; 6: 27-33 Bulgular: KOAH akut atağında olan erkek ve kadın olgularda yaş, semptom ve bulgular, akciğer radyografisi bulguları, egzersiz kapasitesi, Charlson Komorbidite İndeksi puanı, Ottawa KOAH Risk Skalası puanı birbirine benzerdi (p>0,05). Erkeklerin sigara öyküsü anlamlı olarak daha yüksek; fonksiyonel kapasite ise anlamlı olarak daha dü-şüktü (p<0,05). Kadınların vücut kitle indeksi, APACHE II puanı ve akut fizyoloji skoru, erkeklerden anlamlı olarak daha yüksekti (p<0,05). Erkek ve kadın bireyler arasında medikal tedavi, solunum desteği ve fizyoterapi uygulamaları ve hastanede kalış süresi açısından istatistiksel olarak anlamlı fark bulunmadı (p>0,05).Sonuç: KOAH akut atağında kadın ve erkek hastalar; fiziksel, fizyolojik ve klinik özellik-ler açısından farklılık göstermektedir. Kadınlarda sigara öyküsü daha azdır ve günlük yaşama katılımları daha iyidir. KOAH akut atağındaki kadın olguların hastalık şiddeti daha fazla olmasına rağmen, fizyoterapi uygula...

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Gender effect on prognosis of patients receiving long-term home oxygen therapy. The Respiratory Failure Research Group in Japan.

Cited by 86 publications

References 0 publications

Gender and Chronic Obstructive Pulmonary Disease

Gender and Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease prognostic score: A new index

Effects of Gender on Physical, Physiological, and Clinical Characteristics in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

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