2004
DOI: 10.1016/j.yjmcc.2004.04.023
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Gender modulation of Ca2+ uptake in cardiac mitochondria

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Cited by 61 publications
(57 citation statements)
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“…This value is between the reported fluxes of Ca +2 measured in isolated mitochondria for physiologic conditions (32 to 350 nmol Ca 2+ /g/s). 25,26 Moreover, the present results show that 5-hydroxydecanoate was able to prevent the postischemic stunning previously seen in CPG hearts pretreated with 10 mmol/L Clzp, 17 suggesting opposite effects of both drugs. This was confirmed by the reappearance of stunning when Clzp was increased to 30 mmol/L under CPG + 100 mmol/L 5-hydroxydecanoate ( Fig.…”
Section: Discussionsupporting
confidence: 61%
“…This value is between the reported fluxes of Ca +2 measured in isolated mitochondria for physiologic conditions (32 to 350 nmol Ca 2+ /g/s). 25,26 Moreover, the present results show that 5-hydroxydecanoate was able to prevent the postischemic stunning previously seen in CPG hearts pretreated with 10 mmol/L Clzp, 17 suggesting opposite effects of both drugs. This was confirmed by the reappearance of stunning when Clzp was increased to 30 mmol/L under CPG + 100 mmol/L 5-hydroxydecanoate ( Fig.…”
Section: Discussionsupporting
confidence: 61%
“…chondria (0.3 mg/ml) were incubated in 2 ml of buffer D, and redox state of PNs was measured in the presence of glutamate-malate (5 mM-2.5 mM) or succinate (5 mM) Ϯ rotenone (1 M). Redox state of PN was calculated as described by Arieli et al (2): NAD(P)H ratio ϭ (F s Ϫ Fmin)/(Fmax Ϫ Fmin), where Fs is the fluorescence measured after addition of respiratory substrates, Fmin is the baseline fluorescence of mitochondria measured in the absence of respiratory substrates, which represents PNs in their fully oxidized form, and F max is the fluorescence recorded after addition of 2 M antimycin A, which represents PNs in their fully reduced form. Preliminary experiments indicated that F min values measured with this method were similar to those obtained when mitochondria were uncoupled by the addition of 100 nM CCCP.…”
Section: Methodsmentioning
confidence: 99%
“…However, similar to the mammalian heart, the trout heart is hypoxia-intolerant and experiences pronounced decrements in contractile function (2,24,33). During these periods, oxidation of fatty acids will be limited and ATP production is likely to be supported by anaerobic glycolysis.…”
mentioning
confidence: 99%