Gender-Related Cytokine Patterns in Sera of Schistosomiasis Patients with Symmers' Fibrosis

Silva-Teixeira, David Nascimento; Contigli, Christiane; Lambertucci, José Roberto; Serufo, José Carlos; Rodrigues, Virmondés

doi:10.1128/cdli.11.3.627-630.2004

Cited by 16 publications

(20 citation statements)

References 33 publications

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“…In a recent study [53], the authors showed no significant difference in levels of IL-10 in individuals with different degrees of periportal fibrosis due to schistosomiasis. This is in agreement with Silva-Teixeira et al [25], who demonstrated no association between levels of IL-10 and parasite burden and that this cytokine may thus not be involved in periportal fibrosis development during schistosomiasis. In several studies on schistosomiasis, IL-10 appears to be a key cytokine in the regulatory process which prevents pathology.…”

Section: Discussionsupporting

confidence: 82%

“…Reiman et al [24] discussed the involvement of IL-5 in granuloma formation around S. mansoni eggs in the liver, since this cytokine participates in eosinophil growths and activation, contributing to a significant source of profibrotic mediators such as IL-13. In addition, Silva-Teixeira et al [25] reported that serum levels of IL-5 were higher in patients with a severe degree of periportal fibrosis than in those without fibrosis. While levels of IL-5 were similar in the groups in our study, we found higher levels of IL-13 in the CSF and serum in the SMR group compared to in patients with HAM and OND.…”

Section: Discussionmentioning

confidence: 99%

“…While levels of IL-5 were similar in the groups in our study, we found higher levels of IL-13 in the CSF and serum in the SMR group compared to in patients with HAM and OND. This cytokine has been described as the key cytokine associated with periportal fibrosis development in schistosomiasis, acting as an inducer of tissue lesions [25]. Immune response with high serum levels of Th2 cytokines and chemokines has also been described in patients with SMR [26].…”

Section: Discussionmentioning

confidence: 99%

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Immunological Profile in Individuals with Schistosomal Myeloradiculopathy

Kruschewsky

Cardoso²,

Fernandes³

et al. 2016

Neuroimmunomodulation

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Background: Schistosomal myeloradiculopathy (SMR) is the most serious ectopic presentation of Schistosoma mansoni infection. The pathogenesis occurs mainly via the host inflammatory response to the eggs of the parasite that are stuck in the central nervous system, and the diagnosis is generally made by the exclusion of other neurological diseases. Objective: We aimed to evaluate the immune status of SMR patients and to identify a marker for SMR diagnosis. Methods: We enrolled 15 patients with a presumptive diagnosis of SMR, and the control groups included 17 patients with myelopathy associated with human T cell lymphotropic virus type 1 (HTLV-1) and 11 with other neurological disorders. The determination of soluble egg antigen-specific IgE and the levels of cytokines from Th1, Th2, Th17 and T-regulatory cell profiles and the chemokines MIP-1a and RANTES were measured in the cerebrospinal fluid (CSF) and serum using an ELISA technique. Results: We observed that SMR leads to an increase in IgE levels in the CSF compared to serum, and the levels of IL-13 and MIP-1α were significantly higher in the CSF and serum of the SMR patients than in the patients with HTLV-1-associated myelopathy. The levels of MIP-1α and RANTES were higher in the CSF than in the serum of the SMR group. The ratio between levels of IL-13, MIP-1α and RANTES over IL-10 was positive in the CSF of the SMR patients. Conclusions: These results indicate that S. mansoni-specific IgE in the CSF is a promising marker for the diagnosis of SMR and that the cytokines and chemokines associated with the Th2 profile may be important factors in the immunopathogenesis of SMR.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Immunological Profile in Individuals with Schistosomal Myeloradiculopathy

Kruschewsky

Cardoso²,

Fernandes³

et al. 2016

Neuroimmunomodulation

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“…40 Furthermore, TNF-␣ overexpression is associated with PH, 41 although TNF-␣ blockade may not suppress experimental PH. 42 Measurement of TNF-␣ in whole lung lysates in S. mansoni infected and uninfected wild-type, IL-13R␣1 Ϫ/Ϫ , and IL-13R␣2 Ϫ/Ϫ mice revealed an increased level in only the wild-type infected mice compared with all other groups (Supplemental Figure 8C, see http://ajp.amjpathol.org).…”

Section: Org)mentioning

confidence: 99%

Schistosomiasis-Induced Experimental Pulmonary Hypertension

Graham

Mentink‐Kane

El-Haddad

et al. 2010

The American Journal of Pathology

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The mechanisms underlying schistosomiasis-induced pulmonary hypertension (PH), one of the most common causes of PH worldwide, remain unclear. We sought to determine whether Schistosoma mansoni causes experimental PH associated with pulmonary vascular remodeling in an interleukin (IL)-13-dependent manner. IL-13R␣1 is the canonical IL-13 signaling receptor, whereas IL-13R␣2 is a competitive nonsignaling decoy receptor. Wild-type, IL-13R␣1 ؊/؊ , and IL-13R␣2 ؊/؊ C57BL/6J mice were percutaneously infected with S. ؊/؊ mice. Phosphorylated Smad2/3, a target of transforming growth factor-␤ signaling, was increased in both infected mice and humans with the disease. Our data indicate that experimental schistosomiasis causes PH and potentially relies on up-regulated IL-13 signaling.

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“…3,4 Upstream of the TH2 pathway, IL-10 is implicated in negotiating the balance between TH1 and TH2 immunity, involving a third class of T reg cells. 5,6 During chronic schistosomiasis infection, IL-10 production also reduces collateral tissue damage and TH2-induced fibrosis in the liver [7][8][9][10] in response to deposition of S. mansoni eggs. 4 In addition to have a function in host defense against helminthic infection, the TH2 pathway is pathologically activated in atopic diseases (including asthma) in response to stimulus by environmental allergens.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

et al. 2010

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Interleukin (IL)-10 is a regulatory cytokine of the helper T cell type 2 (TH2) pathway, which underlies both the host defense to helminthic infection and atopic diseases, including asthma. Although IL10 promoter polymorphisms are associated with increased atopy risk, IL10 variation has not been thoroughly explored in schistosomiasis-endemic populations. Three atopyrelated IL10 promoter polymorphisms (rs1800896, rs1800871 and rs1800872), complemented by six tagging single-nucleotide polymorphisms (SNPs), were genotyped in 812 individuals in 318 nuclear families from a schistosomiasis-endemic area in Brazil. Associations between markers and total serum Immunoglobulin E (tIgE) levels, indicating non-specific activation of the TH2 pathway, and Schistosoma mansoni fecal egg counts, indicating burden of infection reflecting effectiveness of schistosomiasis host immunity, were performed using family-based transmission disequilibrium tests for quantitative traits (QTDTs). Alleles A, T and A at the three promoter SNPs rs1800896, rs1800871 and rs1800872 were associated with high tIgE levels in the same direction as in atopy populations (P ¼ 0.0008, 0.026 and 0.045), but not with egg counts. IL10 promoter polymorphisms appear to influence non-specific tIgE levels, but not schistosomiasis-specific immunity. The tagging SNP rs3024495 was associated with high S. mansoni egg counts (P ¼ 0.005), suggesting a novel locus in IL10 may influence clinically relevant burden of infection.

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Gender-Related Cytokine Patterns in Sera of Schistosomiasis Patients with Symmers' Fibrosis

Cited by 16 publications

References 33 publications

Immunological Profile in Individuals with Schistosomal Myeloradiculopathy

Immunological Profile in Individuals with Schistosomal Myeloradiculopathy

Schistosomiasis-Induced Experimental Pulmonary Hypertension

Polymorphisms in IL10 are associated with total Immunoglobulin E levels and Schistosoma mansoni infection intensity in a Brazilian population

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