Gender‐related differences in erythrocyte glutathione peroxidase activity in healthy subjects

Massafra, C; Gioia, Dino; Felice, Claudio De; Muscettola, Michela; Longini, Mariangela; Buonocore, Giuseppe

doi:10.1046/j.1365-2265.2002.01657.x

Cited by 42 publications

(31 citation statements)

References 30 publications

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“…GPx activity was found to be significantly increased after 16 weeks of EPT and was consistent with previous studies [1,20]. There was a significant increase in GPx activity after 3 and 6 months of Premarin and Provera therapy in postmenopausal women [1].…”

Section: Discussionsupporting

confidence: 80%

“…There was a significant increase in GPx activity after 3 and 6 months of Premarin and Provera therapy in postmenopausal women [1]. In addition, the erythrocytes GPx were positively correlated with serum estrogen levels in both premenopausal women and HRT-treated postmenopausal women [20]. Estrogen has been suggested to exert its antioxidant effects via the modulation of intracellular GPx activity [20].…”

Section: Discussionmentioning

confidence: 99%

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Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Shafin

Othman

Zakaria

et al. 2014

ISRN Oxidative Medicine

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This study aimed to investigate the ability of Tualang honey (TH), a phytoestrogen, to reduce blood oxidative stress levels/activities in postmenopausal women and compared the effects with the standard estrogen progestin therapy (EPT). A total of 78 healthy postmenopausal women were randomly assigned to one of two groups; EPT group received Femoston conti 1/5 (1 mg 17 -estradiol and 5 mg dydrogesterone), and TH group, received 20 g of TH supplement daily for 16 weeks. The reduced glutathione to oxidized glutathione ratio (GSH : GSSG), plasma glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and 4-hydroxynonenal (4-HNE) levels/activities were measured at pre-and postinterventions using commercially available kits. The plasma GPx and CAT activities were notably increased, and plasma 4-HNE level was significantly decreased in postmenopausal women who received EPT and TH supplementation. TH supplementation for 16 weeks was able to reduce blood oxidative stress levels/activities of postmenopausal women comparable to those who received EPT. Thus, TH has a potential to be used as antioxidant therapy to combat oxidative stress-induced neurodegenerative diseases. This trial is registered with NCT01300676.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Shafin

Othman

Zakaria

et al. 2014

ISRN Oxidative Medicine

View full text Add to dashboard Cite

show abstract

“…Because the Ϫ602A/G, ϩ2C/T, and Ala 5 /Ala 6 polymorphisms were not examined in the population, the haplotype configuration was unknown. Although the level of erythrocyte GPx activity is higher in women than in men (26) and smoking reduces the activity (27), the information for sex and smoking was not shown. These factors may affect the result, which is inconsistent with our result.…”

Section: Discussionmentioning

confidence: 99%

Functional Variants in the Glutathione Peroxidase-1 (GPx-1) Gene Are Associated With Increased Intima-Media Thickness of Carotid Arteries and Risk of Macrovascular Diseases in Japanese Type 2 Diabetic Patients

et al. 2004

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“…This coupled with evidence to support an increased susceptibility of the male fetus to maternal oxidative stress (31) may contribute to the observed greater risk in males. It is also possible that the antioxidant properties of female sex hormones (64,65) may mitigate damaging effects of prenatal ambient PM exposure. Future studies are needed to corroborate our findings and further examine these mechanisms to better understand observed sex differences.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Particulate Air Pollution and Asthma Onset in Urban Children. Identifying Sensitive Windows and Sex Differences

Hsu¹,

Chiu²,

Coull

et al. 2015

Am J Respir Crit Care Med

276

104

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Rationale: The influence of particulate air pollution on respiratory health starts in utero. Fetal lung growth and structural development occurs in stages; thus, effects on postnatal respiratory disorders may differ based on timing of exposure.Objectives: We implemented an innovative method to identify sensitive windows for effects of prenatal exposure to particulate matter with a diameter less than or equal to 2.5 mm (PM 2.5 ) on children's asthma development in an urban pregnancy cohort.Methods: Analyses included 736 full-term (>37 wk) children. Each mother's daily PM 2.5 exposure was estimated over gestation using a validated satellite-based spatiotemporal resolved model. Using distributed lag models, we examined associations between weekly averaged PM 2.5 levels over pregnancy and physician-diagnosed asthma in children by age 6 years. Effect modification by sex was also examined.Measurements and Main Results: Most mothers were ethnic minorities (54% Hispanic, 30% black), had 12 or fewer years of education (66%), and did not smoke in pregnancy (80%). In the sample as a whole, distributed lag models adjusting for child age, sex, and maternal factors (education, race and ethnicity, smoking, stress, atopy, prepregnancy obesity) showed that increased PM 2.5 exposure levels at 16-25 weeks gestation were significantly associated with early childhood asthma development. An interaction between PM 2.5 and sex was significant (P = 0.01) with sex-stratified analyses showing that the association exists only for boys.Conclusions: Higher prenatal PM 2.5 exposure at midgestation was associated with asthma development by age 6 years in boys. Methods to better characterize vulnerable windows may provide insight into underlying mechanisms.

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Gender‐related differences in erythrocyte glutathione peroxidase activity in healthy subjects

Cited by 42 publications

References 30 publications

Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Functional Variants in the Glutathione Peroxidase-1 (GPx-1) Gene Are Associated With Increased Intima-Media Thickness of Carotid Arteries and Risk of Macrovascular Diseases in Japanese Type 2 Diabetic Patients

Prenatal Particulate Air Pollution and Asthma Onset in Urban Children. Identifying Sensitive Windows and Sex Differences

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