Gender-related differences in patients with colon cancer resection

Braun, Rüdiger; Benecke, Claudia; Nolde, J.; Kleemann, Markus; Zimmermann, Markus; Keck, Tobias; Laubert, Tilman

doi:10.1007/s10353-018-0513-5

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…In colorectal cancer, Yang et al conducted a meta-analysis to reveal that males had worse overall survival and cancer-specific survival than females 23 . Previous studies and several meta-analyses in various solid tumors including gastric cancer suggested that males are tended to have postoperative complications more frequently than females as shown in our results 24 , 25 . Whereas Sah et al indicated that females were more prone to have postoperative complications following gastric cancer surgery 26 , 27 .…”

Section: Discussionsupporting

confidence: 72%

Differences of clinical features and outcomes between male and female elderly patients in gastric cancer

Arakawa,

Komatsu,

Kamiya

et al. 2023

Sci Rep

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Although the average life span differs between males and females, little is known about differences in clinical features and short and long-term outcomes between elderly male and female gastric cancer patients. This study was designed to clarify these issues to identify the possibility for sex-based treatment strategies in elderly gastric cancer patients. This study included 295 consecutive elderly gastric cancer patients (75 years or older) who underwent curative gastrectomy between 1997 and 2016. We defined postoperative complications as Clavien–Dindo classification grade II or higher. Comorbidities were present in 67% of all patients. Males tended to have more comorbidities than females (P = 0.077). Male patients had significantly more upper gastric cancers (P = 0.001), a higher incidence of postoperative complications (P = 0.045), and poorer prognoses than females (P = 0.003). Multivariate analysis revealed that being male was an independent risk factor for postoperative complications (Odds ratio 2.5, P = 0.045) and a poor prognostic factor (Hazard ratio 1.81, P = 0.008). Patients who underwent limited surgery without postoperative complications tended to have a better prognosis than patients receiving standard surgery with postoperative complications (3-year overall survival: 78% vs. 55%, P = 0.156). Male was an independent risk factor for postoperative complications and an independent poor prognostic factor in elderly gastric cancer patients. To avoid postoperative complications, the limited surgery might be justified for high-risk elderly male patients.

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Section: Discussionsupporting

confidence: 72%

Differences of clinical features and outcomes between male and female elderly patients in gastric cancer

Arakawa,

Komatsu,

Kamiya

et al. 2023

Sci Rep

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Quality of colon resection results in Upper Austria based on a prospective database

et al. 2020

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Sex-related differences in oncological surgery and postoperative outcomes: comprehensive, nationwide study in France

Jochum,

Hamy,

Gougis

et al. 2024

British Journal of Surgery

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Background The main objective of this study was to undertake an exhaustive investigation of sex-related differences in cancer surgery. Methods This observational study used data from the French national health insurance system database covering 98.8% of the population. Patients diagnosed with non-sex-specific solid invasive cancers between January 2018 and December 2019 were included. The main outcomes were likelihood of undergoing cancer surgery, type of oncological surgery performed, and associated 30-, 60-, and 90-day postoperative reoperation and mortality rates, by sex. Results For the 367 887 patients included, women were 44% more likely than men to undergo cancer surgery (OR 1.44, 95% c.i. 1.31 to 1.59; P < 0.001). However, the likelihood of surgery decreased with advancing age (OR 0.98, 0.98 to 0.98; P < 0.001), and with increasing number of co-morbid conditions (OR 0.95, 0.95 to 0.96; P < 0.001), especially in women. Men had higher 90-day reoperation (21.2 versus 18.8%; P < 0.001) and mortality (1.2 versus 0.9%; P < 0.001) rates than women, overall, and for most cancer types, with the exception of bladder cancer, for which the 90-day mortality rate was higher among women (1.8 versus 1.4%; P < 0.001). After adjustment for age, number of co-morbid conditions, and surgical procedure, 90-day mortality remained higher in men (OR 1.16, 1.07 to 1.26; P < 0.001), and men were 21% more likely than women to undergo reoperation within 90 days (OR 1.21, 1.18 to 1.23; P < 0.001). Conclusion Women were much more likely than men to undergo cancer surgery than men, but the likelihood of surgery decreased with advancing age and with increasing number of co-morbid conditions, especially in women. These findings highlight a need for both increased awareness and strategies to ensure gender equality in access to oncological surgical treatment and improved outcomes.

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Gender-related differences in patients with colon cancer resection

Cited by 3 publications

References 48 publications

Differences of clinical features and outcomes between male and female elderly patients in gastric cancer

Differences of clinical features and outcomes between male and female elderly patients in gastric cancer

Quality of colon resection results in Upper Austria based on a prospective database

Sex-related differences in oncological surgery and postoperative outcomes: comprehensive, nationwide study in France

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