Gender-related impact on outcomes of high density lipoprotein in acute ST-elevation myocardial infarction

Distelmaier, Klaus; Schrutka, Lore; Wurm, Raphael; Seidl, Veronika; Arfsten, Henrike; Cho, Anna; Manjunatha, S; Perkmann, Thomas; Strunk, Guido; Lang, Irene M.; Adlbrecht, Christopher

doi:10.1016/j.atherosclerosis.2016.06.037

Cited by 8 publications

(8 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also notable is the role of sex hormones in lipid metabolism that is in turn linked to innate cellular activation and risk of non-AIDS morbidity and mortality in HIV infection [ 126 , 127 ]. Of note, recent data suggests that there may be sex-specific responses to lipid-lowering therapy, with women showing qualitatively greater reductions in sCD163 after treatment with pitavastatin [ 128 ].…”

Section: Potential Mechanismsmentioning

confidence: 99%

Sex Differences in HIV Infection

2018

View full text Add to dashboard Cite

Purpose of ReviewThis review will outline the multilevel effects of biological sex on HIV acquisition, pathogenesis, treatment response, and prospects for cure. Potential mechanisms will be discussed along with future research directions.Recent FindingsHIV acquisition risk is modified by sex hormones and the vaginal microbiome, with the latter acting through both inflammation and local metabolism of pre-exposure prophylaxis drugs. Female sex associates with enhanced risk for non-AIDS morbidities including cardiovascular and cerebrovascular disease, suggesting different inflammatory profiles in men and women. Data from research on HIV cure points to sex differences in viral reservoir dynamics and a direct role for sex hormones in latency maintenance.SummaryBiological sex remains an important variable in determining the risk of HIV infection and subsequent viral pathogenesis, and emerging data suggest sex differences relevant to curative interventions. Recruitment of women in HIV clinical research is a pathway to both optimize care for women and to identify novel therapeutics for use in both men and women.

show abstract

Section: Potential Mechanismsmentioning

confidence: 99%

Sex Differences in HIV Infection

2018

View full text Add to dashboard Cite

show abstract

“…Monocyte activation has been linked to soluble markers of inflammation that are associated with morbidity and mortality [ 102 ] and have been mechanistically linked to coagulation abnormalities that may contribute to cardiovascular events in HIV-infected individuals [ 103 , 104 ]. Of note, lipid metabolism pathways are linked to monocyte and innate cellular activation in the general population (reviewed in [ 105 ]), and lipids are modulated by sex hormones [ 106 ]. Although there are limited studies in patients with HIV, in uninfected populations, lower percentages of CD14 + CD16 ++ monocytes have been reported in healthy women [ 107 ], and increased monocyte activation has been reported in women with systemic lupus erythematosus [ 108 ].…”

Section: Immune Response and Pathogenesismentioning

confidence: 99%

“…Although there are limited studies in patients with HIV, in uninfected populations, lower percentages of CD14 + CD16 ++ monocytes have been reported in healthy women [ 107 ], and increased monocyte activation has been reported in women with systemic lupus erythematosus [ 108 ]. Lipid metabolism is linked to innate cellular activation (reviewed in [ 105 ]) and the sex hormone effects on lipids [ 106 ] are a potential mechanism for differences between men and women. Soluble markers of innate immune activation are predictive of HIV disease outcomes in cohort studies, but it is not clear if their performance is accurate in women.…”

Section: Immune Response and Pathogenesismentioning

confidence: 99%

Sex Differences in HIV Infection: Mystique Versus Machismo

Scully

2018

PAI

View full text Add to dashboard Cite

Biological sex is a determinant of both susceptibility to and pathogenesis of multiple infections, including HIV. These differences have effects on the spectrum of HIV disease from acquisition to eradication, with diverse mechanisms including distinct chromosomal complements, variation in microbiota composition, hormonal effects on transcriptional profiles, and expression of different immunoregulatory elements. With a comparative biology approach, these sex differences can be used to highlight protective and detrimental immune activation pathways, to identify strategies for effective prevention, treatment, and curative interventions.

show abstract

“…In the current issue of Atherosclerosis, the article by Distelmaier et al [7] has focused on the antioxidant role of HDL during myocardial infarction (MI). In addition, the authors show that this effect is unrelated to particle plasma concentration but is influenced by gender.…”

mentioning

confidence: 99%