Gender specific association of endothelial nitric oxide synthase gene (Glu298Asp) polymorphism with essential hypertension in a south Indian population

Periaswamy, Ramu; Umamaheswaran, Gurusamy; Shewade, Deepak Gopal; Cherian, Akkarapatty; Swaminathan, Rathinam Palamalai; Dutta, Tarun Kumar; Jayaraman, Balachander; Chandrasekaran, Adithan

doi:10.1016/j.cca.2008.06.002

Cited by 25 publications

(26 citation statements)

References 26 publications

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“…Estrogen exerts its antiinfl ammatory effects on the vasculature through different mechanisms such as direct antioxidant effect, generation of nitric oxide, prevention of apoptosis in vascular cells and suppression of cytokines and the renin-angiotensin system (34). Although we did not fi nd any infl uence of age in the results described here, we cannot discard the notion that the differences in MS susceptibility related to 894G>T NOS3 polymorphism could be explained by estrogen modulation, considering the reports in the literature.…”

Section: Discussioncontrasting

confidence: 72%

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Piccoli

Gottlieb

Castro

et al. 2008

Arq Bras Endocrinol Metab

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Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a signifi cant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist. A síndrome metabólica (SM) é um agrupamento de fatores de riscos cardiovasculares, tais como hipertensão, dislipidemia, obesidade e diabetes tipo 2. Realizou-se um estudo caso-controle para analisar a associação entre o polimorfi smo (894G>T do gene da enzima endotelial oxido nítrico sintetase (NOS3) e a SM em 616 voluntários. As freqüências genotípicas foram: TT = 9,3%, GG = 37,2% e TG = 53,6%, e as freqüências alélicas T = 0,36 e G = 0,64. Observou-se freqüência mais alta do genótipo TT em homens com SM do que nos controles, independentemente de outros fatores (p = 0,02). Também observou-se associação entre hipertensão e o genótipo TT nas mulheres. Os dados do estudo sugerem que o polimorfi smo 894G>T pode ter papel significativo na interação entre riscos metabólicos, tais como a hipertensão e a SM, ainda que existam diferenças relacionadas ao sexo.

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Section: Discussioncontrasting

confidence: 72%

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Piccoli

Gottlieb

Castro

et al. 2008

Arq Bras Endocrinol Metab

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“…In 1998, Yoshimura et al first reported that the Glu being supplanted by Asp in the 298th led to the alteration of α helix to tight fold which influenced the activity of eNOS and increased the EH risk (37). In 2008, Periaswamy et al carried out a case control study in 438 hypertensive patients and 444 healthy control subjects in a south Indian Tamilian population and found that the eNOS G894T gene polymorphism is a candidate gene for hypertension and the association is gender specific for females (38). In 2010, Sandrim et al examined whether eNOS G894T gene polymorphisms affected the therapeutic responses of women with gestational hypertension (GH) or preeclampsia (PE), they found that eNOS TT haplotype affected the responsiveness to antihypertensive therapy in PE in Brazil (39).…”

Section: Discussionmentioning

confidence: 99%

Endothelial Nitric Oxide Synthase G894T Gene Polymorphism and Essential Hypertension in the Chinese Population: a Meta-Analysis Involving 11,248 Subjects

2011

Intern. Med.

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Background The endothelial nitric oxide synthase (eNOS) G894T gene polymorphism has been suggested to be linked to the risk of essential hypertension (EH), however the results are still debatable. Objective and Methods To assess the association between eNOS G894T gene polymorphism and EH, such electronic databases as Pubmed, Embase, Web of Science, China Biological Medicine Database (CBMD) and China National Knowledge Infrastructure (CNKI) were searched. The selection criteria were as follows: a) Evaluation of the association of eNOS G894T gene polymorphism and EH. b) EH diagnosis in compliance with EH diagnosis criteria of the World Health Organization (WHO) in 1999. c) The study results were in line with the Hardy-Weinberg equilibrium (HWE). In 23 separate studies with 11,248 subjects the relation between eNOS G894T gene polymorphism and EH was analyzed by current meta-analysis. Random effect model was used to calculate the pooled odds ratio (ORs) and its corresponding 95% confidence interval (95% CI). Results In this eNOS G894T gene polymorphism and EH meta-analysis in the Chinese population, the distribution of T allele frequency was 0.154 for EH group and 0.128 for the control group. A significant association was found between G894T gene polymorphism and EH (p=0.0007). The pooled OR for the distribution frequency of T allele was 1.33 (95% CI:1.13-1.56, Pheterogeneity <0.00001). In the stratified analysis by ethnicity, there was a significant association in Han subgroup (p=0.005). The pooled OR for the distribution frequency of T allele was 1.31 (95% CI:1.09-1.59, Pheterogeneity <0.00001). No significant increased risk for EH was found in the non-Han subgroup (p=0.08). Conclusion In the current meta-analysis, T allele of eNOS G894T gene was suggested to be related to the increased risk of EH in the Chinese population, particularly in those of Han ethnicity.

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“…These studies revealed genetic variations in TIM genes in the loci tested between the Chinese Hui population and other ethnic groups, including the Chinese Han population (Xu et al, 2011(Xu et al, , 2012a. Similarly, genetic association studies on the polymorphism of the eNOS gene and susceptibility to EH have indicated the existence of genetic variations in the eNOS gene among different ethnic populations (Benjafield et al, 2000;Chen et al, 2001;Zhao et al, 2006;Dell'Omo et al, 2007;Deng et al, 2007;Khawaja et al, 2007;Colomba et al, 2008;Periaswamy et al, 2008;Srivastava et al, 2008;Tang et al, 2008;Patkar et al, 2009;Li et al, 2011;Li, 2011;Men et al, 2011). These results may imply a genetic association of eNOS gene polymorphism with susceptibility to EH in the Chinese Hui group.…”

Section: Introductionmentioning

confidence: 96%

“…Nitric oxide (NO) is known to be able to diffuse from the vascular endothelium to the smooth muscle cells in the vessel wall, where it activates soluble guanylate cyclase, sequentially leading to the relaxation of the vascular smooth muscle cell and to vasodilatation. Recently, increasing evidence suggests that polymorphisms of the endothelial NO synthase (eNOS) gene are associated with human EH, and certain genetic variations have been found among different ethnicities (Miyamoto et al, 1998;Benjafield and , 2000;Jachymova et al, 2001;Zhao et al, 2006;Khawaja et al, 2007;Periaswamy et al, 2008;Srivastava et al, 2008;Tang et al, 2008;Patkar et al, 2009;Li et al, 2011;Li, 2011;Men et al, 2011). eNOS is expressed in the endothelium and is encoded by a gene located on chromosome 7q35-36, comprising 26 exons that span 21 kb (Bonnardeaux et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population

Yang

Xu²,

Liu³

et al. 2013

Genet. Mol. Res.

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ABSTRACT.We investigated a possible association of polymorphism of the eNOS gene and essential hypertension in the Chinese Hui population; polymorphisms of rs2070744 (T>C), rs1799983 (G>T), rs1800780 (A>G), and rs3918181 (A>G) loci of the eNOS gene were examined. We found that the genotypic frequencies at rs1799983 and rs1800780 loci differed significantly between patients with essential hypertension and control cohorts. The allelic frequency of the rs1799983 locus also differed significantly between essential hypertension patients and non-essential hypertension controls in this population. Additionally, the G allele of the rs1799983 locus was less frequent in the essential hypertension patients than in controls, with an odds ratio (OR) value of 3.851 [95% confidence interval (95%CI) = 2.236-6.631]. This is an indication of a protective factor of essential hypertension in Chinese Hui people. Haplotype analysis using the 4 SNPs revealed 15 haplotypes. Haplotype frequencies of . We conclude that polymorphism of the eNOS gene is associated with susceptibility to essential hypertension in the Chinese Hui population.

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Gender specific association of endothelial nitric oxide synthase gene (Glu298Asp) polymorphism with essential hypertension in a south Indian population

Cited by 25 publications

References 26 publications

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome

Endothelial Nitric Oxide Synthase G894T Gene Polymorphism and Essential Hypertension in the Chinese Population: a Meta-Analysis Involving 11,248 Subjects

Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population

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