Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population

Villanueva-Ortega, Eréndira; Garcés-Hernández, María José; Herrera-Rosas, Arturo; López-Alvarenga, Juan Carlos; Laresgoiti-Servitje, Estibalitz; Escobedo, Galileo; Queipo, Gloria; Cuevas-Covarrubias, Sergio A.; Garibay-Nieto, Guadalupe N.

doi:10.1016/j.aohep.2019.04.012

Cited by 35 publications

(33 citation statements)

References 41 publications

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“…In our study, NC measurements have allowed us to propose cutoff points in our pubertal male population. These results are an interesting finding in our population considering that previous work from our group [36] analyzed other anthropometric and metabolic variables (HOMA-IR, WC, ALT, AST, visceral adiposity index and triglyceride levels) and found that these variables have associations with NAFLD only in the female population, suggesting that males have a higher risk of being underdiagnosed because of the lack of clinical or metabolic characteristics usually associated with this disease. The association of NC and NAFLD in the males of our study provides us with a tool to suspect NAFLD in this population.…”

Section: Discussionsupporting

confidence: 68%

Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity

Peña-Vélez

Garibay-Nieto

Cal-y-Mayor-Villalobos

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disorder in the pediatric population and has grown along with the obesity pandemic in which we live today. Adipose tissue storage in the upper body segment has been positively correlated with visceral adiposity and metabolic disease, which suggests that neck circumference could represent an easily accessible and replicable anthropometric measurement to identify patients with a higher risk of developing NAFLD. The main purpose of this study is to determine if there is an association between neck circumference and NAFLD. The secondary objectives are to establish cutoff values based on gender and puberty staging.MethodsWe included a sample pediatric population of 112 patients diagnosed with obesity aged between 6 and 18 years. We performed anthropometric and metabolic measurements on every patient, and NAFLD diagnosis was determined with hepatic ultrasound.ResultsThe neck circumference was larger in NAFLD pediatric patients compared to those without NAFLD (p = 0.001). In a multivariate analysis, the neck circumference was associated with NAFLD as an independent risk factor (odds ratio [OR] = 1.172; 95% CI = 1.008–1.362; p = 0.038). Tanner 2–3 = 35 cm and Tanner 4–5 = 38 cm were established as risk cutoff values to develop NAFLD in the male adolescent population.ConclusionsThere is an association between the neck circumference and NAFLD in pediatric patients with obesity, particularly in the male population.

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Section: Discussionsupporting

confidence: 68%

Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity

Peña-Vélez

Garibay-Nieto

Cal-y-Mayor-Villalobos

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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“…In comparing studies, males are more likely to develop NAFLD (37). Another study showed that the prevalence of NAFLD in boys was 24.51% and in girls was 11.96% (OR=2.39; 95% CI=1.10-5.19; p-value = 0.025) (26). The prevalence and severity of NAFLD are higher in men than in women.…”

Section: Methodsmentioning

confidence: 98%

Prevalence of Nonalcoholic Fatty Liver Diseases Among Obese Adults in Mosul City.

Abdulghani¹,

Al-Abachii²

2021

PJMHS

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Objective: The present study's objective is to determine the prevalence of nonalcoholic fatty liver among obese adults in Mosul City, Iraq. Methodology: A prospective study design was applied to achieve the present study's objectives for November 1, 2019, to March 1, 2020. The total sample size was 225. All subjects were selected purposively from outpatient clinics at Al-Salam Teaching Hospital, Ibn Sina Teaching Hospital, and Mosul General Hospital. Results: Among obese adults, the prevalence of NAFLD is 68%; among the 225 patients examined herein,153 had NAFLD. Parameter comparisons between NAFLD and without NAFLD subjects and indicated the mean BMI was (38.8±4) Kg/m2 and (34.1±2.4) Kg/m2, respectively. WC was (106.6±3.9) cm in the NAFLD group and (102.7±3.3) cm in the subject without the NAFLD group. The mean triceps skinfold thickness was (3.8±1.4) cm in the NAFLD group and (2.9±0.9) cm in the subject without the NAFLD group. All parameters had high significance. Recommendations: Further studies on large populations are needed to facilitate the generalization of the current findings. Keywords: Fatty Liver, Nonalcoholic, Mosul

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“…Gender-associated differences in the prevalence and severity of NAFLD are well-recognized. In adolescents, NAFLD is generally more prevalent in males than in females (29,(120)(121)(122). Among obese US adolescents, boys were 6 times more likely than girls to have elevated alanine aminotransferase (ALT) concentrations (121).…”

Section: Gender-associated Nafld and The Involvement Of The Gut Microbiotamentioning

confidence: 99%

Role of the Gut Microbiota in Regulating Non-alcoholic Fatty Liver Disease in Children and Adolescents

Tokuhara

2021

Front. Nutr.

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Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in children and adolescents. Although obesity is the leading cause of NAFLD, the etiologies of NAFLD are multifactorial (e.g., high-fat diet, a lack of exercise, gender, maternal obesity, the antibiotic use), and each of these factors leads to dysbiosis of the gut microbiota community. The gut microbiota is a key player in the development and regulation of the gut mucosal immune system as well as the regulation of both NAFLD and obesity. Dysbiosis of the gut microbiota promotes the development of NAFLD via alteration of gut-liver homeostasis, including disruption of the gut barrier, portal transport of bacterial endotoxin (lipopolysaccharide) to the liver, altered bile acid profiles, and decreased concentrations of short-chain fatty acids. In terms of prevention and treatment, conventional approaches (e.g., dietary and exercise interventions) against obesity and NAFLD have been confirmed to recover the dysbiosis and dysbiosis-mediated altered metabolism. In addition, increased understanding of the importance of gut microbiota-mediated homeostasis in the prevention of NAFLD suggests the potential effectiveness of gut microbiota-targeted preventive and therapeutic strategies (e.g., probiotics and fecal transplantation) against NAFLD in children and adolescents. This review comprehensively summarizes our current knowledge of the gut microbiota, focusing on its interaction with NAFLD and its potential therapeutic role in obese children and adolescents with this disorder.

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Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population

Cited by 35 publications

References 41 publications

Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity

Association between neck circumference and non-alcoholic fatty liver disease in Mexican children and adolescents with obesity

Prevalence of Nonalcoholic Fatty Liver Diseases Among Obese Adults in Mosul City.

Role of the Gut Microbiota in Regulating Non-alcoholic Fatty Liver Disease in Children and Adolescents

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