Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris

Huang, Yukun; Liu, Lu; Chen, Linna; Zhou, Lin; Xiong, Xia; Deng, Yongqiong

doi:10.5021/ad.2021.33.6.531

Cited by 12 publications

(14 citation statements)

References 40 publications

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“…A variety of evidence has proved a link between the gut microbiota and acne. Previous studies found that patients with acne had dysbiosis of the gut microbiota [20][21][22]. However, to date, no study has analyzed the characteristics of gut microbiota in patients with truncal acne, and further studies are needed.…”

Section: Pathophysiology Of Truncal Acnementioning

confidence: 99%

Truncal Acne: An Overview

Woo

Kim

2022

JCM

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Acne is a relatively common disease of the pilosebaceous units. Many aspects of facial acne have been studied. However, there is limited evidence regarding truncal acne. Truncal acne is also observed in a significant number of patients, but it is often ignored by patients and clinicians. Although the pathogenesis of facial and trunk acne is considered to be similar, the characteristics of the skin on the trunk and face are thought to be different. As truncal acne can cause scars on large areas of the body and adversely affect the quality of life of patients, more attention should be given to patients with truncal acne. Although only a few studies have been published to date, the epidemiology, etiology, severity assessment tool, assessments of the quality of life, and new treatments targeting truncal acne are currently being studied. Therefore, in this review, the latest knowledge on truncal acne will be discussed.

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Section: Pathophysiology Of Truncal Acnementioning

confidence: 99%

Truncal Acne: An Overview

Woo

Kim

2022

JCM

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“…More recently, Deng’s researcher group conducted a study in which they analyzed possible discrepancies in the intestinal microbiota and fecal metabolites between men and women with acne, since it is unknown whether gut dysbiosis and its associated metabolism are sex-dependent in subjects with acne [ 105 ]. Alpha diversity was lower in men with acne compared to control men, but no significant differences were found between women with acne and control women.…”

Section: Acne Vulgaris and Gut Microbiotamentioning

confidence: 99%

Acne, Microbiome, and Probiotics: The Gut–Skin Axis

et al. 2022

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The objective of this narrative review was to check the influence of the human microbiota in the pathogenesis of acne and how the treatment with probiotics as adjuvant or alternative therapy affects the evolution of acne vulgaris. Acne is a chronic inflammatory skin disease involving the pilosebaceous units. The pathogenesis of acne is complex and multifactorial involving genetic, metabolic, and hormonal factors in which both skin and gut microbiota are implicated. Numerous studies have shown the bidirectionality between the intestinal microbiota and skin homeostasis, a communication mainly established by modifying the immune system. Increased data on the mechanisms of action regarding the relevance of Cutibacterium acnes, as well as the importance of the gut–skin axis, are becoming known. Diverse and varied in vitro studies have shown the potential beneficial effects of probiotics in this context. Clinical trials with both topical and oral probiotics are scarce, although they have shown positive results, especially with oral probiotics through the modulation of the intestinal microbiota, generating an anti-inflammatory response and restoring intestinal integrity, or through metabolic pathways involving insulin-like growth factor I (IGF-1). Given the aggressiveness of some standard acne treatments, probiotics should continue to be investigated as an alternative or adjuvant therapy.

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“…Several studies have shown that the GM of patients with acne differs from that of healthy controls. Acne patients have lower microbial diversity, a lower abundance of Firmicutes, and an increase in Bacteroidetes [ 176 , 183 , 184 ]. These differences are gender-dependent, as male acne patients have higher dysbiosis levels than females [ 183 ].…”

Section: Microbiota–gut–skin Axis (Mgs)mentioning

confidence: 99%

“…Acne patients have lower microbial diversity, a lower abundance of Firmicutes, and an increase in Bacteroidetes [ 176 , 183 , 184 ]. These differences are gender-dependent, as male acne patients have higher dysbiosis levels than females [ 183 ]. Similarly, a decrease in the number of bacterial phyla with anti-inflammatory properties and producers of metabolites, such as SCFAs, with antimicrobial and immunomodulatory activity has been reported.…”

Section: Microbiota–gut–skin Axis (Mgs)mentioning

confidence: 99%

“…Similarly, a decrease in the number of bacterial phyla with anti-inflammatory properties and producers of metabolites, such as SCFAs, with antimicrobial and immunomodulatory activity has been reported. These include Bifidobacterium , Butyricicoccus , Lactobacillus , Lactococcus , Clostridium , Clostridiales, Lachnospiraceae, and Ruminococcus [ 176 , 183 , 184 ]. This suggests that patients with acne have ID, which may exacerbate the skin manifestations of this pathology.…”

Section: Microbiota–gut–skin Axis (Mgs)mentioning

confidence: 99%

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Probiotics: Protecting Our Health from the Gut

et al. 2022

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The gut microbiota (GM) comprises billions of microorganisms in the human gastrointestinal tract. This microbial community exerts numerous physiological functions. Prominent among these functions is the effect on host immunity through the uptake of nutrients that strengthen intestinal cells and cells involved in the immune response. The physiological functions of the GM are not limited to the gut, but bidirectional interactions between the gut microbiota and various extraintestinal organs have been identified. These interactions have been termed interorganic axes by several authors, among which the gut–brain, gut–skin, gut–lung, gut–heart, and gut–metabolism axes stand out. It has been shown that an organism is healthy or in homeostasis when the GM is in balance. However, altered GM or dysbiosis represents a critical factor in the pathogenesis of many local and systemic diseases. Therefore, probiotics intervene in this context, which, according to various published studies, allows balance to be maintained in the GM, leading to an individual’s good health.

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Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris

Cited by 12 publications

References 40 publications

Truncal Acne: An Overview

Truncal Acne: An Overview

Acne, Microbiome, and Probiotics: The Gut–Skin Axis

Probiotics: Protecting Our Health from the Gut

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