Gender-Specific Features of Arterial Hypertension Development and Treatment

Hudz, Nataliia; Stepaniuk, Nataliia; Stepaniuk, Alla

doi:10.32383/appdr/130048

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Furthermore, the mortality caused by CKD and DM increased twice between 1990 and 2010 (Danaei et al 2014). Cardiovascular diseases are recognized to be the major health and social issue in the world as well (Stepaniuk et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Chronic kidney disease and dialysis therapy: incidence and prevalence in the world

Filipska¹,

Bohdan²,

Wieczorek³

et al. 2021

PHAR

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Сhronic kidney disease (CKD) is the important public and medical problem in the world because of a large burden on health care systems. The prevalence of CKD and number of dialysis patients are increasing in the world. The prevalence and incidence of CKD depends on age, race, and gender of patients, region, and the presence of the CKD registry in a country. Diabetes mellitus (DM) and arterial hypertension (AH) are the most common causes of end stage renal disease (ESRD). It is projected that the number of dialysis patients will reach 5.5 million in 2030. Specific strategies and interventions should be urgently aimed at reducing in the burden of CKD by means of the prevention, detection and treatment of DM, AH, and early stages of CKD. One more strategy is the organization of own domestic manufacture of solutions for dialysis therapy.

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Section: Introductionmentioning

confidence: 99%

Chronic kidney disease and dialysis therapy: incidence and prevalence in the world

Filipska¹,

Bohdan²,

Wieczorek³

et al. 2021

PHAR

Self Cite

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Methodological aspects of the acid hemodialysis concentrates development

Filipska

Hudz

2020

AML

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The aim of this paper is to develop a scientifically based methodology for the development of acid concentrates in order to perform purposefully organized research on the implementation of these concentrates into industrial manufacture. Material and Methods. Methodological concept of acid concentrates development. The objects of the study are liquid acid concentrates for hemodialysis containing sodium chloride, potassium chloride, calcium chloride hexahydrate, magnesium chloride hexahydrate, acetic acid and glucose. Methods of the study included bibliosemantic analysis, systematization of theoretical and practical material, and generalization of data. Results and Discussion. The methodology of the development of acid concentrates for hemodialysis is substantiated. To ensure the effectiveness and safety of the concentrates, it is necessary to theoretically and experimentally justify all pharmaceutical factors that affect the quality of the concentrates (active substances, solvent, technological processes, and packaging materials). The methodology of development of acid concentrates consists of the following stages of research: information retrieval, technological, analytical, and biological. The methodological concept is based on the implementation of the combination of marketing, technological, pharmacotechnological, physicochemical, chemical. and biopharmaceutical studies that ensure compliance of the developed products with medical, biological and pharmaceutical requirements for quality and safety of concentrates for renal replacement therapy. Conclusion.The authors developed and substantiated the methodology and drew up a plan of experimental research on the elaboration of the acid concentrates for renal replacement therapy in order to organize their industrial manufacture. Keywords: chronic kidney disease, methodology of pharmaceutical development, concentrates for hemodialysis

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Gender-Specific Features of Arterial Hypertension Development and Treatment

Cited by 2 publications

References 21 publications

Chronic kidney disease and dialysis therapy: incidence and prevalence in the world

Chronic kidney disease and dialysis therapy: incidence and prevalence in the world

Methodological aspects of the acid hemodialysis concentrates development

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