Gene bookmarking by the heat shock transcription factor programs the insulin-like signaling pathway

Das, Srijit; Min, Sehee; Prahlad, Veena

doi:10.1016/j.molcel.2021.09.022

Cited by 19 publications

(20 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent analysis found correlated epigenetic changes at the stress-regulating glucocorticoid receptor gene in the hippocampus, which emerged during nursing, persisted into adulthood and were necessary for the behavioral responses [167]. Similar forms of epigenetic embryonic programming have now been found in other contexts [168], [169].…”

Section: Epigenetic Mechanisms Of Development and Learningmentioning

confidence: 63%

Learning Outside the Brain: Integrating Cognitive Science and Systems Biology

Gunawardena

2022

Proc. IEEE

View full text Add to dashboard Cite

Learning is commonplace in organisms such as ourselves and even in organisms as far distant as the bee and the octopus. Such learning is implemented by brains, or neuronal networks, and has been extensively studied within ethology, psychology, cognitive science, and neuroscience.Whether learning also takes place in nonneuronal settings has remained a matter of sustained controversy, too often dominated by ideological views. In this survey, I will explain how learning can be rigorously interpreted as a form of information processing and then explore the evidence for whether learning also takes place in organismal contexts outside the brain, such as physiology, development, and individual cells. I will try to explain why it is important to build bridges in this way between cognitive science and systems biology, why concepts and methods from various branches of engineering may be helpful in this task, and what the eventual impact may be on how we think about the organism.

show abstract

Section: Epigenetic Mechanisms Of Development and Learningmentioning

confidence: 63%

Learning Outside the Brain: Integrating Cognitive Science and Systems Biology

Gunawardena

2022

Proc. IEEE

View full text Add to dashboard Cite

show abstract

“…The HSP70 promoter is known to be bookmarked in condensed chromatin during the cell cycle in HeLa cells [ 63 , 65 ], and the HSF–HSP pathway may have more critical roles in cancer cells than in normal cells. We cannot describe here whether both the HSF–HSP pathway and gene bookmarking by HSF are critically important in normal cells; however, recent studies reported that other transcription factors have the gene bookmarking function and that this function has been discovered in normal mammalian cells and in Caenorhabditis elegans [ 91 , 92 , 93 ]. Therefore, the molecular mechanism of the relationship between the HSF–HSP pathway, cell cycle progression, cell canceration, and gene bookmarking is notable and must be further elucidated.…”

Section: Change In Hsf1 Expression Level Induces Cell Cycle Arrestmentioning

confidence: 99%

Cell Cycle Regulation by Heat Shock Transcription Factors

Tokunaga

Otsuyama

Hayashida

2022

Cells

View full text Add to dashboard Cite

Cell division and cell cycle mechanism has been studied for 70 years. This research has revealed that the cell cycle is regulated by many factors, including cyclins and cyclin-dependent kinases (CDKs). Heat shock transcription factors (HSFs) have been noted as critical proteins for cell survival against various stresses; however, recent studies suggest that HSFs also have important roles in cell cycle regulation-independent cell-protective functions. During cell cycle progression, HSF1, and HSF2 bind to condensed chromatin to provide immediate precise gene expression after cell division. This review focuses on the function of these HSFs in cell cycle progression, cell cycle arrest, gene bookmarking, mitosis and meiosis.

show abstract

“…For example, Skinner (2014) suggested next‐generation inheritance following parental exposure to toxins, and using a Caenorhabditis elegans model, Das et al. (2021) established that there is a heritable epigenetic memory to prior heat stress exposures.…”

Section: Historical Observations On the Role Of Epigenetics In Heat A...mentioning

confidence: 99%

“…Though we do not know whether it can also be carried in the female, it is carried in the female in other species. such as C. elegans (Das et al., 2021).…”

Section: Inherited Epigenetic Memory Of Previous Heat Exposurementioning

confidence: 99%

Epigenetic responses to heat: From adaptation to maladaptation

Murray

Clanton

Horowitz

2022

Experimental Physiology

View full text Add to dashboard Cite

New Findings What is the topic of this review?This review outlines the history of research on epigenetic adaptations to heat exposure. The perspective taken is that adaptations reflect properties of hormesis, whereby low, repeated doses of heat induce adaptation (acclimation/acclimatization); whereas brief, life‐threatening exposures can induce maladaptive responses. What advances does it highlight?The epigenetic mechanisms underlying acclimation/acclimatization comprise specific molecular programmes on histones that regulate heat shock proteins transcriptionally and protect the organism from subsequent heat exposures, even after long delays. The epigenetic signalling underlying maladaptive responses might rely, in part, on extensive changes in DNA methylation that are sustained over time and might contribute to later health challenges. Abstract Epigenetics plays a strong role in molecular adaptations to heat by producing a molecular memory of past environmental exposures. Moderate heat, over long periods of time, induces an ‘adaptive’ epigenetic memory, resulting in a condition of ‘resilience’ to future heat exposures or cross‐tolerance to other forms of toxic stress. In contrast, intense, life‐threatening heat exposures, such as severe heat stroke, can result in a ‘maladaptive’ epigenetic memory that can place an organism at risk of later health complications. These cellular memories are coded by post‐translational modifications of histones on the nucleosomes and/or by changes in DNA methylation. They operate by inducing changes in the level of gene transcription and therefore phenotype. The adaptive response to heat acclimation functions, in part, by facilitating transcription of essential heat shock proteins and exhibits a biphasic short programme (maintaining DNA integrity, followed by a long‐term consolidation). The latter accelerates acclimation responses after de‐acclimation. Although less studied, the maladaptive responses to heat stroke appear to be coded in long‐lasting changes in DNA methylation near the promoter region of genes involved with basic cell function. Whether these memories are also encoded in histone modifications is not yet known. There is considerable evidence that both adaptive and maladaptive epigenetic responses to heat can be inherited, although most evidence comes from lower organisms. Future challenges include understanding the signalling mechanisms responsible and discovering new ways to promote adaptive responses while suppressing maladaptive responses to heat, as all life forms adapt to life on a warming planet.

show abstract

Gene bookmarking by the heat shock transcription factor programs the insulin-like signaling pathway

Cited by 19 publications

References 107 publications

Learning Outside the Brain: Integrating Cognitive Science and Systems Biology

Learning Outside the Brain: Integrating Cognitive Science and Systems Biology

Cell Cycle Regulation by Heat Shock Transcription Factors

Epigenetic responses to heat: From adaptation to maladaptation

Contact Info

Product

Resources

About