Gene Delivery Systems: Recent Progress in Viral and Non-Viral Therapy

Cevher, Erdal; Sezer, Ali Demir; Çağlar, Emre Şefik

doi:10.5772/53392

Cited by 46 publications

(60 citation statements)

References 81 publications

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“…Thus, liposomes can be different in size and surface charge. [21,28] The studies showed that viral vectors and then polymeric vectors are more effective than liposomes for in vivo gene delivery. The disadvantages of liposomes include short time gene expression, low level of transgene expression, and poor physiological stability.…”

Section: Lipid-based Non-viral Vectorsmentioning

confidence: 99%

“…The disadvantages of liposomes include short time gene expression, low level of transgene expression, and poor physiological stability. [28] In this line, PEGylation (poly (ethylene) glycol) could improve liposomal circulation half-life in vivo through reduction of clearance and recognition by immune system as well as the restriction of non-specific absorption of serum proteins. [44] Several liposome-based vectors (e.g., Allovectin-7 R , USA) have been used in clinical trials for cancer therapy.…”

Section: Lipid-based Non-viral Vectorsmentioning

confidence: 99%

“…The researchers concentrated on three strategies for polymeric gene transporters such as: encapsulation, electrostatic interaction, and adsorption. [28] Cationic polymer-based gene carriers indicated good biodegradability, low toxicity, and relatively higher transfection efficiency than liposomes. The structural diversity in polymers for gene delivery contains cationic residues, endosomal escape units, and degradable fragments.…”

Section: Polymersmentioning

confidence: 99%

“…[26] Dendrimers: Dendrimers contain a central core, repeating units, and terminal function groups. [21,28] Despite other polymers, dendrimers can be made by modification of the surface functional groups with hydrophilic groups (or positive charge). The repeated functional groups and symmetrical structure of dendrimers lead to effectively encapsulate the genes and high delivery to targeted sites.…”

Section: Polymersmentioning

confidence: 99%

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Different strategies of gene delivery for treatment of cancer and other disorders

Agi

Mosaferi

Khatamsaz

et al. 2016

JST

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Gene therapy is the gene transfer into host cells for treatment of acquired and genetic disorders. For this purpose, there are a wide variety of gene delivery methods with special properties including viral and non-viral vectors. The non-viral methods use physical forces or chemical compounds (natural or synthetic) to transfer DNA into a cell. The efficiency of the non-viral gene therapy depends on conquering four different intra-and extra-cellular barriers such as cellular uptake, endosomal escape, nuclear entry, and gene expression. Among various gene carriers, some viral vectors such as Adenovirus, Lentivirus, Vaccinia as well as gene gun and lipofection achieved to clinical trials. In this mini-review, we briefly describe different approaches for gene delivery and their applications in various phases of clinical trials.

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Section: Lipid-based Non-viral Vectorsmentioning

confidence: 99%

Section: Lipid-based Non-viral Vectorsmentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

Section: Polymersmentioning

confidence: 99%

See 2 more Smart Citations

Different strategies of gene delivery for treatment of cancer and other disorders

Agi

Mosaferi

Khatamsaz

et al. 2016

JST

View full text Add to dashboard Cite

show abstract

“…Various diseases are occurred in human beings due to mutations or deletions in genes lead to metabolic pathway disorder, regulation of cell cycle, protein function and its structure, function of receptor, and cell skeleton [2]. This can be treated effectively through gene delivery system.…”

Section: Introductionmentioning

confidence: 99%