Gene delivery to brain cells with apoprotein E derived peptide conjugated to polylysine (apoEdp-PLL)

Mousazadeh, Mohammad H.; Palizban, Abbasali; Salehi, Rasool; Salehi, Mansoor

doi:10.1080/10611860601148908

Cited by 24 publications

(10 citation statements)

References 14 publications

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“…Specifically, LRP1 is a multifunctional receptor that interacts with a range of ligands, such as apolipoprotein E (ApoE), α 2 -macroglobulin, aprotinin, amyloid precursor protein, and Aß [213]. One of the first examples of targeted gene delivery to the brain by means of P(Lys) nanocarriers was reported by Mousazadeh and co-workers using this receptor to shuttle them across the BBB [214]. An LDL receptor-binding peptide dimer (LRKLRKRLLR-LRKLRKRLLR) derived from its endogenous ligand ApoE was conjugated to P(Lys) 16 .…”

Section: Low-density Lipoprotein Receptorsmentioning

confidence: 99%

Designing peptide nanoparticles for efficient brain delivery

Duro‐Castaño

Leite

Forth

et al. 2020

Advanced Drug Delivery Reviews

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Low-density Lipoprotein Receptorsmentioning

confidence: 99%

Designing peptide nanoparticles for efficient brain delivery

Duro‐Castaño

Leite

Forth

et al. 2020

Advanced Drug Delivery Reviews

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“…Mannosebased ligands were conjugated PLL vectors to target human antigen-presenting cells [139]. PLL was also used for gene delivery targeting brain cells by conjugating with ApoE derived peptides [140].…”

Section: Poly-l-lysine (Pll)mentioning

confidence: 99%

Recent Advances in Biological Strategies for Targeted Drug Delivery

Yang²

2009

CHDDT

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Targeted drug delivery system, consisting of a guidance component, a transport vehicle and the drug, is aiming at distributing the drugs to a specific organ or cell type in a sufficient concentration to achieve the high efficiency and alleviate the side-effects of the drugs. During the past decade, besides physical and chemical methods, biological strategies have been developing at an amazing speed improving the drug targeting system. These include: i) searching for guidance components, which include integrin ligands, extracellular matrix proteins, carbohydrates, vitamins, antibodies, nucleic acid aptamers and peptides, leading the whole system to the targeting sites; ii) development of the transport vehicles, such as polymers and plasmid/virus vectors that play the role in carrying drugs and protecting them on their way to the destination; and iii) the design or selection of an effective drug, the "final bullet" that functions on the targeting site, to test the efficiency of the system. Here, we briefly review the recent advances on the development of the most essential targeted drug delivery systems and strategies, and particularly focusing on the progress in discovery of the ligand components and construction of carrying vehicles for drug targeted delivery systems. In addition, we briefly discuss the prospect of this field.

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“…Cationic liposomes and cationic polymers such as polylysine [141,142], poly(glutamic acid) and their derivatives [143], PEI [144][145][146][147][148][149][150][151], PPI [152,153], PPE [154], …”

Section: Peptide Dendrimers As Gene Deliveriesmentioning

confidence: 99%