Gene dose effect: intraband mapping of the &lt;i&gt;LDH A &lt;/i&gt;locus using cells from four individuals with different interstitial deletions of 11p

Francke, Uta; George, Donna L.; Brown, Milton; Riccardi, Vincent M.

doi:10.1159/000130809

Cited by 66 publications

(18 citation statements)

References 4 publications

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“…In the human genome, RRM1 has recently been mapped to the short arm of chromosome 11 (Engstrom and Francke, 1985). Thus RRM1 is linked to the lactate dehydrogenase gene (LDHA) on human chromosome II (Francke et al, 1977;Lewis et al" 1985). Since LDHA has also been mapped to hamster chromosome 3 (Adair el al., 1983).…”

Section: Discussionmentioning

confidence: 99%

Chromosomal assignment of amplified genes in hydroxyurea-resistant hamster cells

Tonin¹,

Stallings²,

Carman³

et al. 1987

Cytogenet Genome Res

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We have shown previously that cDNAs for the Ml and M2 subunits of ribonucleotide reductase, ornithine decarboxylase (ODC), and p5–8, a 55,000-Dalton protein, hybridize to amplified genomic sequences in a highly hydroxyurea-resistant hamster cell line. We have extended these observations to include two additional, independently isolated, hydroxyurea-resistant cell lines: SC8, a single-step hamster ovary cell line, and KH450, a multistep human myeloid leukemic cell line, have also undergone genomic amplification for sequences homologous to ODC and p5–8 cDNAs. However, neither SC8 nor KH450 contains amplified genomic sequences homologous to an Ml cDNA probe. A panel of mouse-hamster somatic cell hybrids was used to map sequences homologous to Ml, M2, ODC, and 5–8 cDNAs in the hamster genome. The M2, ODC, and p5–8 cDNAs hybridized to DNA fragments that segregated with hamster chromosome 7. In contrast, Ml cDNA hybridized to DNA fragments that segregated with hamster chromosome 3. These data suggest that the genes RRM2, (M2), ODC, and p5–8, but not RRM1 (Ml), are linked and may have been co-amplified in the selection of the hydroxyurea-resistant hamster and human cell lines.

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Section: Discussionmentioning

confidence: 99%

Chromosomal assignment of amplified genes in hydroxyurea-resistant hamster cells

Tonin¹,

Stallings²,

Carman³

et al. 1987

Cytogenet Genome Res

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“…1 -11 One additional case was reported with del(11)(p11p12), but it is unclear if this child had the features of PSS. 12 PSS is a contiguous gene syndrome (CGS) with two genes implicated in specific clinical features of this disorder. Exostosin 2 (EXT2 [MIM*60821) maps within 11p11.2 13,14 and mutations in this gene result in the autosomal dominant condition of isolated hereditary multiple exostoses [MIM#133701].…”

Section: Introductionmentioning

confidence: 99%

Construction of a natural panel of 11p11.2 deletions and further delineation of the critical region involved in Potocki–Shaffer syndrome

et al. 2005

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“…and PTH have been assigned to the short arm of human chromosome II (Deisseroth et al. 1978;Franckc et al;1979, Junien cl al. ;Naylor et al, 1981;McBride et al, 1982) and to two separate chromosomes, 2 and 7, of the mouse (Lalley et al.…”

Section: Discussionmentioning

confidence: 99%

Owl monkey gene mapping: the assignment of gene loci for catalase, β-globin gene cluster, HRAS1, insulin, and parathyroid hormone

Ma¹,

Gerhard

Housman

et al. 1986

Cytogenet Genome Res

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Using somatic cell genetics and Southern blot hybridization, we have mapped five structural genes in the owl monkey, coding for catalase (CAT), the β-globin gene cluster (HBBC), c-Ha-ras 1 (HRAS1), insulin (INS), and parathyroid hormone (PTH). All five loci are mapped to chromosome 19 of karyotype VI (2n = 49,50) of the owl monkey; CAT, HBBC, INS, and PTH can be assigned to chromosome 4 of karyotype V (2n = 46), while CAT and HBBC can be assigned to chromosome 2 of karyotype III (2n = 53). Using in situ hybridization, the CAT gene was precisely mapped on the mid-region and the β-globin gene cluster on the telomeric end of chromosome 2q(K-ΠI). Our results provide significant insight into the evolutionary history of these gene loci. While these loci are separated into at least two major segments in rodents such as the mouse, our results suggest conservation of a single chromosome arm among higher primates.

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Gene dose effect: intraband mapping of the <i>LDH A </i>locus using cells from four individuals with different interstitial deletions of 11p

Cited by 66 publications

References 4 publications

Chromosomal assignment of amplified genes in hydroxyurea-resistant hamster cells

Chromosomal assignment of amplified genes in hydroxyurea-resistant hamster cells

Construction of a natural panel of 11p11.2 deletions and further delineation of the critical region involved in Potocki–Shaffer syndrome

Owl monkey gene mapping: the assignment of gene loci for catalase, β-globin gene cluster, HRAS1, insulin, and parathyroid hormone

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