2022
DOI: 10.1016/j.omto.2022.10.011
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Gene-edited and CAR-NK cells: Opportunities and challenges with engineering of NK cells for immunotherapy

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Cited by 12 publications
(3 citation statements)
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“…They also regulate cancer cell death by patterned recognition of target ligands [ 90 , 91 ]. CAR-T cells can only target tumor cells using specific antibodies against scFv, whereas NK cells can be widely activated through their activating and inhibitory receptors [ 92 ]. The balance between activating and inhibitory receptors in NK cells is important for regulating their cytotoxic activity.…”
Section: Car-nk Cell Therapymentioning
confidence: 99%
“…They also regulate cancer cell death by patterned recognition of target ligands [ 90 , 91 ]. CAR-T cells can only target tumor cells using specific antibodies against scFv, whereas NK cells can be widely activated through their activating and inhibitory receptors [ 92 ]. The balance between activating and inhibitory receptors in NK cells is important for regulating their cytotoxic activity.…”
Section: Car-nk Cell Therapymentioning
confidence: 99%
“…15 CAR-NK cells have also shown remarkable results for different cancer treatments. 16 However, due to the limitations of CAR modification, 17 different alternative nongenetic approaches have been explored, including, antibody, 18 nanobody, 19 lipid-aptamer, 20 antibody−drug conjugates, 21 etc., for the NK cell surface modification. However, NK cells for HCC treatment can be deactivated by NK-HCC cell interaction (NKp30 and MSDCs on HCC) resulting in failure of penetration into the solid tumor tissues.…”
Section: Introductionmentioning
confidence: 99%
“…However, more therapeutic precision is still required to target tumors accurately. Moreover, multiplexed precision genome editing with pros and cons has become a highly flexible and modular toolkit for specifically addressing the challenges of precision interventions ( 35 37 ). Towards better functionality, genome editing tools like CRISPR/Cas9 and TALENs have made it possible to create additional genetic modifications in immune cells ( 36 , 38 , 39 ).…”
mentioning
confidence: 99%