Gene Editing: Friend or Foe? Evidence Indicates Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein (Small 38/2019)

Abstract

In article number 1902686, Jie Wang, Fengmin Lu, and co‐workers indicate the potential of exosomes as a safe and effective delivery vehicle of functional gRNA and Cas9 protein, and the exosomes‐mediated delivery of gene editing activity to adjacent and distant cells or tissues, which may further complicate the off‐target and safety concerns of the CRISPR/Cas9 system.