Gene–environment interaction in atopic diseases: a population‐based twin study of early‐life exposures

Kahr, Niklas; Naeser, Vibeke; Stensballe, Lone Graff; Kyvik, Kirsten Ohm; Skytthe, Axel; Backer, Vibeke; Bønnelykke, Klaus; Thomsen, Simon Francis

doi:10.1111/crj.12110

Cited by 24 publications

(26 citation statements)

References 42 publications

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“…The mechanisms that may underlie the parental effect on offspring are beyond the scope of our current study. The effect may be due to any range of potential parental influences on the offspring including (but not limited to) post‐translational modification, shared environment, microchimerism or passive transfer of immune markers or antibodies …”

Section: Discussionmentioning

confidence: 99%

Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway

Jõgi

Svanes

Siiak

et al. 2017

Clin Experimental Allergy

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Section: Discussionmentioning

confidence: 99%

Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway

Jõgi

Svanes

Siiak

et al. 2017

Clin Experimental Allergy

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“…When timing of clinical assessment relative to offspring birth was not taken into account, paternal clinical markers of allergic disease appeared to be generally more important than the mother's clinical markers for offspring allergic disease. Shared environment appeared to be more important than genetic inheritance in a recent twin study [27]. Effects of shared environment would result in stronger associations between parental and offspring disease for parental disease measured after birth of a child than before.…”

Section: Discussionmentioning

confidence: 90%

“…Shared environment appeared to be more important than genetic inheritance in a recent twin study . Effects of shared environment would result in stronger associations between parental and offspring disease for parental disease measured after birth of a child than before.…”

Section: Discussionmentioning

confidence: 91%

Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring

Bertelsen

Rava

Carsin

et al. 2017

Clin Experimental Allergy

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SummaryBackgroundMice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans.ObjectiveWe aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness (BHR), and total and specific IgEs, measured before conception vs. after birth, with offspring asthma and hayfever.MethodsThe study included 4293 participants (mean age 34, 47% men) from the European Community Respiratory Health Survey (ECRHS) with information on asthma symptom severity, BHR, total and specific IgEs from 1991 to 1993, and data on 9100 offspring born 1972–2012. Adjusted relative risk ratios (aRRR) for associations of parental clinical outcome with offspring allergic disease were estimated with multinomial logistic regressions.ResultsOffspring asthma with hayfever was more strongly associated with parental BHR and specific IgE measured before conception than after birth [BHR: aRRR = 2.96 (95% CI: 1.92, 4.57) and 1.40 (1.03, 1.91), respectively; specific IgEs: 3.08 (2.13, 4.45) and 1.83 (1.45, 2.31), respectively]. This was confirmed in a sensitivity analysis of a subgroup of offspring aged 11–22 years with information on parental disease activity both before and after birth.Conclusion & Clinical RelevanceParental BHR and specific IgE were associated with offspring asthma and hayfever, with the strongest associations observed with clinical assessment before conception as compared to after birth of the child. If the hypothesis is confirmed in other studies, parental disease activity assessed before conception may prove useful for identifying children at risk for developing asthma with hayfever.

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“…Moreover, there are no trials to address whether there is any clinical benefit of caesarean section versus vaginal birth in women with respiratory disease. Advantages of natural vaginal delivery include quicker recovery in those with bronchiectasis or CF and some studies suggested that children born by caesarean section in mothers with asthma may have an increased risk of subsequent asthma [145], while other studies did not [146].…”

Section: Obstetric Considerationsmentioning

confidence: 99%

ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases

et al. 2019

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This European Respiratory Society/Thoracic Society of Australia and New Zealand statement outlines a review of the literature and expert opinion concerning the management of reproduction and pregnancy in women with airways diseases: asthma, cystic fibrosis (CF) and non-CF bronchiectasis. Many women with these diseases are now living into reproductive age, with some developing moderate-to-severe impairment of lung function in early adulthood. The statement covers aspects of fertility, management during pregnancy, effects of drugs, issues during delivery and the post-partum period, and patients’ views about family planning, pregnancy and parenthood. The statement summarises current knowledge and proposes topics for future research, but does not make specific clinical recommendations.

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Gene–environment interaction in atopic diseases: a population‐based twin study of early‐life exposures

Cited by 24 publications

References 42 publications

Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway

Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway

Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring

ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases

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