Gene expression analysis in gonads and brain of catfish Clarias batrachus after the exposure of malathion

Prathibha, Y.; Murugananthkumar, Raju; Rajakumar, Arjuna; Laldinsangi, C.; Sudhakumari, C.C.; Mamta, Sajwan-Khatri; Dutta-Gupta, Aparna; Senthilkumaran, B.

doi:10.1016/j.ecoenv.2013.12.029

Cited by 15 publications

(2 citation statements)

References 46 publications

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“…This is biologically plausible because various OP insecticides exert anti-androgen activity by binding to ERα, ERβ, or AR and by interfering with the expression of genes involved in the metabolism of steroid hormones (Kojima et al, 2004;Manabe et al, 2006). In the present study, urinary MDA seems to be associated with smaller TV and delayed adrenarche, consistent with an animal study in which malathion exposure was found to downregulate gonadal development by targeting the expression pattern of transcription factors, activin A, orphan nuclear or sex steroid receptors, and steroidogenic enzymes (Prathibha et al, 2014). Interestingly, in our study in children from the INMA cohorts at the age of 7-11 years, urinary DETP was associated with delayed puberty onset in boys with overweight or obesity, which is in line with the present results, whereas TCPy was associated with earlier genital growth onset (Castiello et al, 2023), suggesting that the effect of pesticide exposure on pubertal development may depend on the age-time window.…”

Section: Discussionsupporting

confidence: 90%

Exposure to Non-Persistent Pesticides and Sexual Maturation of Spanish Adolescent Males

et al. 2022

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Section: Discussionsupporting

confidence: 90%

Exposure to Non-Persistent Pesticides and Sexual Maturation of Spanish Adolescent Males

et al. 2022

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“…Malathion was also found to reduce testosterone and estradiol synthesis by modulating the expression of genes involved in the secretion of hypothalamic, adrenal, and gonadal hormones (19). These effects on the mechanisms underlying puberty have also been observed for other OP compounds, including diazinon (49), acephate (50), and triazophos (51). Epidemiological studies suggesting interference by OP pesticides in mechanisms regulating sex hormone production have mainly focused on men occupationally exposed to OPs, revealing decreased testosterone levels and elevated levels of FSH or LH or both gonadotrophins (52).…”

Section: Op Pesticidesmentioning

confidence: 72%

Exposure to non-persistent pesticides and puberty timing: a systematic review of the epidemiological evidence

Castiello

Freire

2021

European Journal of Endocrinology

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Background: Numerous modern non-persistent pesticides have demonstrated estrogenic/anti-androgenic activity and have been classified as endocrine disrupting chemicals (EDCs). Processes involved in puberty development are vulnerable to EDCs, such as compounds that interfere with the metabolism or activity of sex steroids. Objective: To conduct a systematic review of epidemiological studies on the relationship between early-life exposure to non-persistent pesticides and puberty timing and/or sexual maturation in girls and boys. Methods: A systematic search was carried out using MEDLINE and SCOPUS databases, including original articles published up to November 2020. Results: Thirteen studies were selected after excluding non-original and non-human studies. Exposure to different types of pesticides has been associated with altered puberty timing in girls and/or boys in eight studies. In utero exposure to atrazine has been related to earlier age of menarche in girls; exposure to organophosphate (OP) pesticides has been related to delayed sexual development in boys and girls; childhood pyrethroid exposure has been associated with pubertal delay in girls and pubertal advancement in boys; and prenatal/childhood exposure to multiple pesticides has been linked to earlier puberty onset in girls and pubertal delay in boys. Conclusions: Most of the reviewed studies describe a relationship between pesticide exposure and changes in the age of puberty onset or sex hormone levels, although the quality of the evidence is generally low. Further well-designed longitudinal studies are warranted on specific classes of pesticides and on possible interactions between different types of compounds.

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Malathion-induced spermatozoal oxidative damage and alterations in sperm quality of endangered trout Salmo coruhensis

Kocabaş

Kutluyer

Benzer

et al. 2017

Environ Sci Pollut Res

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The use of pesticides has been increased along with increasing the farming activities and has caused environmental impacts deleteriously. In particular, non-target organisms including fish can be affected by toxic effects of pesticides. Therefore, the impacts of malathion (MTN) on oxidative stress and sperm quality were investigated in vitro. The MTN concentrations used on this study were 0 (control), 75, 100, and 125 μg/L. Lipid peroxidation (MDA), non-enzymatic (GSH), and enzymatic (SOD, GSH-Px, and CAT) activities in spermatozoa were examined for determination of oxidative stress status. Our findings showed that motility rate and period of sperm cells significantly decreased with exposure to MTN. Biochemical assays revealed that CAT activity and levels of MDA, GSH increased in spermatozoa based on concentration while activity of GSH-Px and SOD decreased. Consequently, spermatozoa were highly sensitive to MTN exposure. MTN has disruptive effects on sperm quality and caused to oxidative stress in spermatozoa.

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Gene expression analysis in gonads and brain of catfish Clarias batrachus after the exposure of malathion

Cited by 15 publications

References 46 publications

Exposure to Non-Persistent Pesticides and Sexual Maturation of Spanish Adolescent Males

Exposure to Non-Persistent Pesticides and Sexual Maturation of Spanish Adolescent Males

Exposure to non-persistent pesticides and puberty timing: a systematic review of the epidemiological evidence

Malathion-induced spermatozoal oxidative damage and alterations in sperm quality of endangered trout Salmo coruhensis

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