Gene expression and regulation in systemic lupus erythematosus

Frangou, Eleni; Βertsias, George; Boumpas, Dimitrios T.

doi:10.1111/eci.12130

Cited by 56 publications

(51 citation statements)

References 69 publications

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“…[38] It is reported that tissue inflammation and chronic infection lead to the overproduction of NO and superoxide anions (O 2 .-), which rapidly combine to yield ONOO -. The studies suggest that most of the cytotoxicity attributed to NO is due to ONOO -in SLE.…”

Section: Discussionmentioning

confidence: 99%

Impact of Anti-Peroxynitrite-Damaged-Thymidine- Monophosphate Antibodies on Disease Activity in Patients with Systemic Lupus Erythematosus

Alghasham

Salloom

Alghamadi³

et al. 2014

Nucleosides, Nucleotides and Nucleic Acids

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Present study probes the role of peroxynitrite (ONOO(-))-modified thymidine-5'-monophosphate (TMP) in SLE patients with different disease activity scores according to the SLE Disease Activity Index (SLEDAI). Serum analysis showed significant increased number of subjects positive for anti-ONOO(-)-TMP-protein antibodies in SLE patients with different SLEDAI scores. Interestingly, the levels of these antibodies were significantly higher among SLE patients, whose SLEDAI scores were ≥20. In addition, a significant correlation was observed between the levels of anti-ONOO(-)-TMP-protein antibodies and the SLEDAI score (r = 0.595, p < 0.0001). In short, this study shows a positive association between anti-ONOO(-)-TMP-protein antibodies and SLEDAI. The stronger response observed in patients with higher SLEDAI scores suggests that anti-ONOO(-)-TMP-protein antibodies may be useful in evaluating the progression of SLE and in elucidating the mechanisms of disease pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Impact of Anti-Peroxynitrite-Damaged-Thymidine- Monophosphate Antibodies on Disease Activity in Patients with Systemic Lupus Erythematosus

Alghasham

Salloom

Alghamadi³

et al. 2014

Nucleosides, Nucleotides and Nucleic Acids

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“…However, these genes and loci only account for 10 to 20% of disease heritability. This indicates that there are many factors still to be identified [45]. REPA inferred 37 TFs associated with the KEGG systemic lupus erythematosus pathway which consists of 138 genes.…”

Section: Number Of Repa's Predictions Per Gene Setmentioning

confidence: 99%

“…Out of those 37 TFs predicted to regulate genes in the SLE pathway, we found literature support for 13 (or 35%). The TFs associated by REPA with SLE are the following (supporting literature is referred to after the corresponding TF): ATF2, ATF3 [46], BCLAF1, CBX3, CEBPB, CEBPD, ETS1 [47], FOS [45], FOXM1, GR [48], HEY1, INI1, JUND [49], MBD4 [50], MTA3, MYBL2, NFATC1 [49], NFIC, P300 [51], PAX5 [52], PML, POL2, POU2F2, RUNX3 [53], RXRA, SIN3AK20, SP1 [54], SP4, STAT5A, TAF1, TAF7, TBP [55], TCF12, TCF3, TEAD4, YY1 [56], and ZBTB33.…”

Section: Number Of Repa's Predictions Per Gene Setmentioning

confidence: 99%

REPA: Applying Pathway Analysis to Genome-Wide Transcription Factor Binding Data

Patra

Izawa

Peña‐Castillo

2018

IEEE/ACM Trans. Comput. Biol. and Bioinf.

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Pathway analysis has been extensively applied to aid in the interpretation of the results of genome-wide transcription profiling studies, and has been shown to successfully find associations between the biological phenomena under study and biological pathways. There are two widely used approaches of pathway analysis: over-representation analysis, and gene set analysis. Recently genome-wide transcription factor binding data has become widely available allowing for the application of pathway analysis to this type of data. In this work, we developed regulatory enrichment pathway analysis (REPA) to apply gene set analysis to genome-wide transcription factor binding data to infer associations between transcription factors and biological pathways. We used the transcription factor binding data generated by the ENCODE project, and gene sets from the Molecular Signatures and KEGG databases. Our results showed that 54 percent of the predictions examined have literature support and that REPA's recall is roughly 54 percent. This level of precision is promising as several of REPA's predictions are expected to be novel and can be used to guide new research avenues. In addition, the results of our case studies showed that REPA enhances the interpretation of genome-wide transcription profiling studies by suggesting putative regulators behind the observed transcriptional responses.

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“…Нарушение сигнального пути IFN I типа, как в крови, так и в пораженных органах, также наблюдали при других ревматических заболеваниях, таких как СКВ, где IFNa играет главную роль в аутоиммунитете и патогенезе заболевания [40]. Например, терапия ронтализумабом (антитела к IFNa) приводила к значительному снижению активности заболевания и манифестации обострений у больных СКВ с низкой экспрессией INF-зависимых генов по сравнению с больными, имеющими высокие уровни экспрессии этих генов [41].…”

Section: анти-в-клеточная терапия при ревматических заболеванияхunclassified

Upcoming value of gene expression analysis in rheumatology

Четина

Маркова

2018

BIOMED KHIM

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Ревматические заболевания (РЗ) -это хронические воспалительные заболевания неизвестной этиологии, в ходе которых нарушаются функции сигнальных путей иммунной системы. Это сопровождается поражением ряда других тканей, болью и разрушением суставов. Современная терапия направлена на коррекцию патофизиологических и биохимических механизмов, ответственных за клиническую манифестацию заболевания. В связи с гетерогенностью больных РЗ существует необходимость персонифицированного лечения, выбор которого осложняется тем, что не все больные одинаково отвечают на терапию. Анализ экспрессии генов представляет инструмент для контроля заболевания и персонализации терапии больных с целью подавления воспаления и боли, а также замедления разрушения суставов.Ключевые слова: ревматические заболевания; ревматоидный артрит; экспрессия генов; провоспалительные цитокины; протеазы; боль

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Gene expression and regulation in systemic lupus erythematosus

Cited by 56 publications

References 69 publications

Impact of Anti-Peroxynitrite-Damaged-Thymidine- Monophosphate Antibodies on Disease Activity in Patients with Systemic Lupus Erythematosus

Impact of Anti-Peroxynitrite-Damaged-Thymidine- Monophosphate Antibodies on Disease Activity in Patients with Systemic Lupus Erythematosus

REPA: Applying Pathway Analysis to Genome-Wide Transcription Factor Binding Data

Upcoming value of gene expression analysis in rheumatology

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