Gene expression in HCV‐associated hepatocellular carcinoma – upregulation of a gene encoding a protein related to the ubiquitin‐conjugating enzyme

El-Nady, G.M.; Ling, Roger; Harrison, Tim J.

doi:10.1034/j.1478-3231.2003.00862.x

Cited by 26 publications

(17 citation statements)

References 23 publications

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“…In Egypt, HCV prevalence amongst general population has been estimated to be around 14% (29). It seems that cirrhosis is the common pathway by which HCV promotes carcinogenesis, but HCV also may play a direct role through involvement of viral gene products in inducing liver cell proliferation (30). In this study, 91.32% of our patients had positive HCV antibodies in their sera.…”

Section: Discussionmentioning

confidence: 53%

Epidemiological characteristics of hepatocellular carcinoma in Egypt: a retrospective analysis of 1313 cases

Shaker

Abdella

Khalifa

et al. 2013

Liver International

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Section: Discussionmentioning

confidence: 53%

Epidemiological characteristics of hepatocellular carcinoma in Egypt: a retrospective analysis of 1313 cases

Shaker

Abdella

Khalifa

et al. 2013

Liver International

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“…Furthermore, UbcH10‐overexpressing NIH3T3 cells exhibit increased bromodeoxyuridine incorporation, enhanced growth rate, increased saturation density, and promotion of colony formation [47]. In addition, a gene encoding a protein related to the ubiquitin conjugating enzyme is overexpressed in HCV‐associated hepatocellular carcinoma, suggesting that the ubiquitin system may be involved in HCV‐related hepatocarcinogenesis [48].…”

Section: Discussionmentioning

confidence: 99%

Altered gene expression in Opisthorchis viverrini‐associated cholangiocarcinoma in hamster model

Loilome

Yongvanit

Wongkham

et al. 2006

Molecular Carcinogenesis

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Cholangiocarcinoma (CCA) induced by liver fluke (Opisthorchis viverrini, Ov) infection is one of the most common and serious disease in northeast Thailand. To elucidate the molecular mechanism of cholangiocarcinogenesis induced by Ov infection, we employed a hamster model of CCA induced by Ov and N-nitrosodimethylamine and analyzed candidate genes involved in CCA using fluorescence differential display-PCR. Of 149 differentially amplified bands we identified, the upregulation of 23 transcripts and downregulation of 1 transcript related to CCA hamsters were confirmed by a reverse northern macroarray blot. The upregulated genes include signal transduction protein kinase A regulatory subunit Ialpha (Prkar1a), myristoylated alanine-rich protein kinase C substrate, transcriptional factor LIM-4-only domain, oxysterol-binding protein involved in lipid metabolism, splicing regulatory protein 9, ubiquitin conjugating enzyme involved in protein degradation, beta tubulin, beta actin, and collagen type VI. Quantitative real-time PCR confirmed that the expression of Prkar1a was significantly higher in CCA and its precursor lesion when compared with normal liver and normal gall bladder epithelia (P<0.05). Prkar1a expression tended to increase along with the progression of biliary transformation from hyperplasia and precancerous lesions to carcinoma. These findings contribute to our understanding of the processes involved in the molecular carcinogenesis of CCA in order to provide a unique perspective on the development of new chemotherapeutics in future.

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“…However, 10-25% of cases developed in the absence of cirrhosis. This is due to the direct oncogenic effect of HBV as in the HBV-DNA genome, which integrates with hepatocellular chromosomes [4]. In contrast to HBV, HCV cannot integrate into the host genome.…”

Section: Introductionmentioning

confidence: 99%

Impact of different biochemical markers in serum of patients with benign and malignant liver diseases

Zakhary

El‐Merzabani

El-Sawi

et al. 2011

Journal of Advanced Research

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Gene expression in HCV‐associated hepatocellular carcinoma – upregulation of a gene encoding a protein related to the ubiquitin‐conjugating enzyme

Abstract: The ubiquitin system may be involved in HCV-related hepatocarcinogenesis and in the development of other cancers.

Cited by 26 publications

References 23 publications

Epidemiological characteristics of hepatocellular carcinoma in Egypt: a retrospective analysis of 1313 cases

Epidemiological characteristics of hepatocellular carcinoma in Egypt: a retrospective analysis of 1313 cases

Altered gene expression in Opisthorchis viverrini‐associated cholangiocarcinoma in hamster model

Impact of different biochemical markers in serum of patients with benign and malignant liver diseases

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