Gene expression profile in a case of primary cutaneous CD30-negative large T-cell lymphoma with a blastic phenotype

Murakami, Takashi; Fukasawa, Tomoki; Fukayama, Masashi; Usui, Keitaro; Ohtsuki, Mamitaro; Nakagawa, Hidemi

doi:10.1046/j.1365-2230.2001.00796.x

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…Our current study demonstrates the utility of cDNA microarray analysis and quantitative real‐time RT‐PCR for the assessment of transcriptional expression patterns of T‐cell malignancies. Very few reports have studied the expression profile of specific T‐cell malignancies [39,40]. Our study represents a comprehensive global expression analysis of a diverse group of T‐cell leukemic lymphomas with actual comparison to a normal T‐cell population.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profiling of cell lines derived from T‐cell malignancies

et al. 2002

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The expression pro¢les of eight cell lines derived from T-cell malignancies were compared to CD4-positive T-cells using cDNA microarray technology. Unsupervised hierarchical clustering of 4364 genes demonstrated substantial heterogeneity resulting in four distinct groups. While no genes were found to be uniformly up-or down-regulated across all cell lines, we observed 111 over-expressed genes (greater than two-fold) and 1118 down-regulated genes (greater than two-fold) in the lymphomas as a group when compared to CD4-positive T-cells. These included genes involved in cytokine signaling, cell adhesion, cytoskeletal elements, nuclear transcription factors, and known oncogenes and tumor suppressor genes. Quantitative £uorescent reverse transcription-polymerase chain reaction analysis demonstrated 70% concordance with the microarray results. While freshly isolated malignant cells may di¡er in their individual expression patterns relative to established cell lines from the same diagnoses, we feel that the variety of di¡erent lymphocytic cell lines that we examined provides a representative picture of the molecular pathogenesis of T-cell malignancies. ß

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Section: Discussionmentioning

confidence: 99%

Gene expression profiling of cell lines derived from T‐cell malignancies

et al. 2002

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CD4+ peripheral T cell lymphoma, not otherwise specified, including primary cutaneous CD4+ small/medium‐sized pleomorphic T cell lymphoma

2016

The Cutaneous Lymphoid Proliferations

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Expression Profiling of T-Cell Lymphomas Differentiates Peripheral and Lymphoblastic Lymphomas and Defines Survival Related Genes

Martı́nez-Delgado¹,

Meléndez²,

Cuadros³

et al. 2004

Clinical Cancer Research

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Purpose: T-Cell lymphomas constitute heterogeneous and aggressive tumors in which pathogenic alterations remain largely unknown. Expression profiling has demonstrated to be a useful tool for molecular classification of tumors.Experimental Design: Using DNA microarrays (CNIOOncoChip) containing 6386 cancer-related genes, we established the expression profiling of T-cell lymphomas and compared them to normal lymphocytes and lymph nodes.Results: We found significant differences between the peripheral and lymphoblastic T-cell lymphomas, which include a deregulation of nuclear factor-B signaling pathway. We also identify differentially expressed genes between peripheral T-cell lymphoma tumors and normal T lymphocytes or reactive lymph nodes, which could represent candidate tumor markers of these lymphomas. Additionally, a close relationship between genes associated to survival and those that differentiate among the stages of disease and responses to therapy was found.Conclusions: Our results reflect the value of gene expression profiling to gain insight about the molecular alterations involved in the pathogenesis of T-cell lymphomas.

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Gene expression profile in a case of primary cutaneous CD30-negative large T-cell lymphoma with a blastic phenotype

Cited by 4 publications

References 9 publications

Gene expression profiling of cell lines derived from T‐cell malignancies

Gene expression profiling of cell lines derived from T‐cell malignancies

CD4+ peripheral T cell lymphoma, not otherwise specified, including primary cutaneous CD4+ small/medium‐sized pleomorphic T cell lymphoma

Expression Profiling of T-Cell Lymphomas Differentiates Peripheral and Lymphoblastic Lymphomas and Defines Survival Related Genes

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