2011
DOI: 10.1128/iai.05727-11
|View full text |Cite
|
Sign up to set email alerts
|

Gene Expression Profiles of Immune Mediators and Histopathological Findings in Animal Models of Leptospirosis: Comparison between Susceptible Hamsters and Resistant Mice

Abstract: Leptospirosis is a widespread zoonosis characterized by multiple organ failure and variable host susceptibility toward pathogenic Leptospira strains. In this study, we put the role of inflammatory mediators in parallel with bacterial burdens and organ lesions by comparing a susceptible animal model, the hamster, and a resistant one, the Oncins France 1 (OF1) mouse, both infected with virulent Leptospira interrogans serovar Icterohaemorrhagiae strain Verdun. Histological observations evidenced edema, congestion… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

6
71
1
4

Year Published

2014
2014
2020
2020

Publication Types

Select...
4
4

Relationship

1
7

Authors

Journals

citations
Cited by 68 publications
(82 citation statements)
references
References 62 publications
6
71
1
4
Order By: Relevance
“…We described tissue lesions during both the acute and chronic stages of infection. Lethal leptospirosis of hamsters infected with the L. interrogans serovar Icterohaemorrhagiae strain Verdun was previously described 13 and, similarly, led to fatality within 4-6 days, as was also observed for the Ballum B3-13S isolate. This contrasts with the mean period before onset of death observed with another serogroup, Ballum strain 4E, in the same animal model, which died between 8 and 18 days postinfection.…”
mentioning
confidence: 87%
See 1 more Smart Citation
“…We described tissue lesions during both the acute and chronic stages of infection. Lethal leptospirosis of hamsters infected with the L. interrogans serovar Icterohaemorrhagiae strain Verdun was previously described 13 and, similarly, led to fatality within 4-6 days, as was also observed for the Ballum B3-13S isolate. This contrasts with the mean period before onset of death observed with another serogroup, Ballum strain 4E, in the same animal model, which died between 8 and 18 days postinfection.…”
mentioning
confidence: 87%
“…14 The B3-13S-infected hamsters revealed severe hemorrhaging, as well as edema and congestion in liver, lung, and kidney tissue at the time of death, similar to lesions observed with other strains. 13,15 Hamsters that survived acute disease developed chronic infection with the B3-13S isolate. Indeed, WS staining and specific qPCR techniques confirmed the presence of Leptospira in the kidneys of infected hamsters at 28 days postinfection.…”
mentioning
confidence: 99%
“…Similar to sepsis, human leptospirosis was reported to be associated with high plasma levels of inflammatory cytokines such as TNF-a, IL-6, IL-8, IL-1b and IL-12 (Matsui et al, 2011;Wang et al, 2012;Reis et al, 2013). Indeed, the production of inflammatory cytokines such as TNF-a by CD4+ T-cells after stimulation with antigens of Leptospira was highest in patients with severe disease (Volz et al, 2015).…”
Section: Discussionmentioning
confidence: 95%
“…Upon Leptospira infection, hamsters that presented features of intense haemorrhage (and, as shown, reduced thrombin inhibitors) also had lower prothrombin levels in the last days of disease, strengthening the activation of the coagulation system, most probably, due to inflammatory cytokines (Matsui et al, 2011). The host response to virulent Leptospira might generate an initial exacerbated coagulation, which would ultimately lead to a lack of coagulation factors and inhibitors during the course of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…(20,(39)(40)(41)(42)(43)(44)(45). Entre estos hallazgos resaltamos los estudios en hámster y tití común (Callithrix jacchus) con especies patógenas de diferente origen y bajo diferentes protocolos de infección.…”
Section: Discussionunclassified