Gene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs

Rangkasenee, Noppawan; Muráni, Eduard; Schellander, K.; Çınar, Mehmet Ulaş; Ponsuksili, Siriluck; Wimmers, Klaus

doi:10.1152/physiolgenomics.00055.2013

Cited by 10 publications

(9 citation statements)

References 67 publications

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“…Presence and (changing) levels of N(A)Ab might thus be a possible new serological marker for increased risk of OC in pigs. This could provide evidence for a role of the immune system in the occurrence of OC as suggested for horses and pigs (Osborne et al, 1995;Rangkasenee et al, 2013).…”

Section: Introductionmentioning

confidence: 55%

“…Various associations of immune reactivity were found with osteoarthritis (reviewed by Haseeb and Haqqi, 2013), which is an advanced degenerative joint disorder and therefore not comparable with OC development at young age. Recently it was indicated in pigs that there are genes associated with the immunological system in relation with OC in pigs (Rangkasenee et al, 2013) indicating an unknown role for the immune system in OC as either a primary contributor of OC development or a secondary response of OC development. The mechanisms that explain the current associations of N(A)Ab with OC remain unknown and speculative.…”

Section: Associations Of Natural (Auto-) Antibodies and Osteochondrosismentioning

confidence: 99%

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Association of natural (auto-) antibodies in young gilts with osteochondrosis at slaughter

et al. 2015

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Section: Introductionmentioning

confidence: 55%

Section: Associations Of Natural (Auto-) Antibodies and Osteochondrosismentioning

confidence: 99%

Association of natural (auto-) antibodies in young gilts with osteochondrosis at slaughter

et al. 2015

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“…), and different functional categories and canonical pathways related to immune responses have been recently implicated in the pathogenesis of OC (Rangkasenee et al . ).…”

Section: Discussionmentioning

confidence: 97%

Candidate gene analysis of osteochondrosis inSpanishPurebred horses

Sevane

Dunner

Boado³

et al. 2016

Animal Genetics

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Equine osteochondrosis (OC) is a frequent developmental orthopaedic disease with high economic impact on the equine industry and may lead to premature retirement of the animal as a result of chronic pain and lameness. The genetic background of OC includes different genes affecting several locations; however, these genetic associations have been tested in only one or few populations, lacking the validation in others. The aim of this study was to identify the genetic determinants of OC in the Spanish Purebred horse breed. For that purpose, we used a candidate gene approach to study the association between loci previously implicated in the onset and development of OC in other breeds and different OC locations using radiographic data from 144 individuals belonging to the Spanish Purebred horse breed. Of the 48 polymorphisms analysed, three single nucleotide polymorphisms (SNPs) located in the FAF1, FCN3 and COL1A2 genes were found to be associated with different locations of OC lesions. These data contribute insights into the complex gene networks underlying the multifactorial disease OC, and the associated SNPs could be used in a marker-assisted selection strategy to improve horse health, welfare and competitive lifespan.

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“…Microarray studies described ANGPTL4 overexpression in cartilage from non-traumatic osteonecrosis of the femoral head, OA (85), and porcine osteochondrosis (86) versus control cartilage, as well as in damaged versus undamaged cartilage from individuals with anteromedial knee OA (87). We observed immunohistochemical overexpression of ANGPTL4 within the OA synovium, although to a lesser extent than in RA.…”

Section: Angptl4 In Other Musculoskeletal Conditionsmentioning

confidence: 99%

Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease

Knowles

2017

Front. Endocrinol.

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Hypoxia and the hypoxia-inducible factor (HIF) transcription factor drive pathological bone loss in conditions including rheumatoid arthritis (RA), osteoarthritis, osteoporosis, primary bone tumours, and bone metastatic cancer. There is therefore considerable interest in determining the function(s) of HIF-induced genes in these pathologies. Angiopoietin-like 4 (ANGPTL4) is an adipose-derived, HIF-1α- and PPARγ-induced gene that was originally discovered as an endocrine and autocrine/paracrine regulator of lipid metabolism. Given the inverse relationship between bone adiposity and fracture risk, ANGPTL4 might be considered a good candidate for mediating the downstream effects of HIF-1α relevant to osteolytic disease. This review will consider the possible roles of ANGPTL4 in regulation of osteoclast-mediated bone resorption, cartilage degradation, angiogenesis, and inflammation, focusing on results obtained in the study of RA. Possible roles in other musculoskeletal pathologies will also be discussed. This will highlight ANGPTL4 as a regulator of multiple disease processes, which could represent a novel therapeutic target in osteolytic musculoskeletal disease.

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Gene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs

Abstract: Rangkasenee N, Murani E, Schellander K, Cinar MU, Ponsuksili S, Wimmers K. Gene expression profiling of articular cartilage reveals functional pathways and networks of candidate genes for osteochondrosis in pigs.

Cited by 10 publications

References 67 publications

Association of natural (auto-) antibodies in young gilts with osteochondrosis at slaughter

Association of natural (auto-) antibodies in young gilts with osteochondrosis at slaughter

Candidate gene analysis of osteochondrosis inSpanishPurebred horses

Multiple Roles of Angiopoietin-Like 4 in Osteolytic Disease

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