2021
DOI: 10.1016/j.jmig.2021.03.011
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Gene Expression Signature of Endometrial Samples from Women with and without Endometriosis

Abstract: Study Objective: To develop a prototype of a complex gene expression biomarker for the diagnosis of endometriosis on the basis of differences between the molecular signatures of the endometrium from women with and without endometriosis. Design: Prospective observational cohort study. Evidence obtained from a well-designed, controlled trial without randomization.

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Cited by 20 publications
(12 citation statements)
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“…It can reliably estimate concentrations of cancer drug targets ( 53 ), which is also true for the emerging non-protein molecular target ganglioside GD2 ( 27 ). In addition, RNAseq data obtained for FFPE biosamples may be used to identify clinically actionable or new fusion oncogenes ( 26 ) and to generate gene signatures that can establish statuses of important tumor biomarkers like microsatellite instability ( 25 , 54 , 55 ) and oncogenic mutations ( 56 ) or that can predict individual sensitivity of a tumor to targeted ( 28 , 57 , 58 ) and non-targeted ( 59 ) therapies. Thus, adding a new option of TMB level assessment may strongly benefit this approach.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…It can reliably estimate concentrations of cancer drug targets ( 53 ), which is also true for the emerging non-protein molecular target ganglioside GD2 ( 27 ). In addition, RNAseq data obtained for FFPE biosamples may be used to identify clinically actionable or new fusion oncogenes ( 26 ) and to generate gene signatures that can establish statuses of important tumor biomarkers like microsatellite instability ( 25 , 54 , 55 ) and oncogenic mutations ( 56 ) or that can predict individual sensitivity of a tumor to targeted ( 28 , 57 , 58 ) and non-targeted ( 59 ) therapies. Thus, adding a new option of TMB level assessment may strongly benefit this approach.…”
Section: Discussionmentioning
confidence: 99%
“…RNA sequencing was performed according to the previous protocol used to generate ANTE collection of healthy tissue RNAseq profiles (23) and several cancer expression collections (22,(24)(25)(26)(27)(28). To isolate RNA preps, 10-mM-thick paraffin slices were trimmed from each FFPE tissue block with a microtome.…”
Section: Rnaseq: Library Preparation and Sequencingmentioning
confidence: 99%
“…Mutations that have been observed, almost exclusively, in the KRAS genes, in the presence of adenomyosis, underscore the importance of these genes in the pathogenesis of the disease at the genetic level. This discovery of the cause-effect relationship between the presence of mutations in the aforementioned [7][8][9] KRAS genes and adenomyosis refuted the recent theory that the reported molecular abnormalities in adenomyosis are mainly epigenetic or associated with abnormal expression in different genes [7][8][9]. Most recognized abnormalities regarding gene expression, were associated with excess estrogen formation, progesterone resistance and were related to steroid hormone receptors and other transcription factors.…”
Section: Genetic Predispositionmentioning
confidence: 91%
“…Adenomyosis, one of the most common diseases in gynecology with a frequency ranging between 5% and 70% , can significantly affect the quality of life of women with clinical symptoms such as menorrhagia, dysmenorrhea and infertility [7][8][9]. There are two prevailing theories concerning the origin of adenomyosis.…”
Section: Genetic Predispositionmentioning
confidence: 99%
“…We also measured the expression of the genes that may play a role in the pathogenesis of adenomyosis (Oh et al, 2013; Artymuk et al, 2019;Inoue et al, 2019;Kim et al, 2020;Adamyan et al, 2021). Kras and Tgb1 stayed at the same level in control and tamoxifen-treated mice at both ages (Figure 3C).…”
Section: Pathological Features and Gene Expression Profile In Tamoxifen-induced Adenomyotic Micementioning
confidence: 95%