Gene polymorphisms of IL-6−174 G/C and IL-1Ra VNTR in asthmatic children

Settin, Ahmad; Zedan, Magdy; Farag, Mohamed; Regal, Mohammed Ezz El; Osman, Engy

doi:10.1007/s12098-008-0161-z

Cited by 25 publications

(21 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The CC genotype was rare in this study, as seen in other reports on asthma (20,21,33,34) and NP (2) . Probably, due to its low frequency, the CC genotype should not play a role in the pathophysiology of NP and asthma.…”

Section: Discussionsupporting

confidence: 77%

“…IL-6 levels could be influenced by a single-nucleotide polymorphism (SNP) at position -174 in the promoter region of the IL-6 gene, that was firstly described by Fishman et al This SNP presents guanosine (G) or cytosine (C) at position -174 and this variability could be functional, because it modifies transcriptional regulation and cytokine levels, thereby leading to an inflammatory phenotype (19) . In our previous study, the frequency of GG genotype was found to be higher in NP patients than in controls (2) and similar results were found in asthma patients (20,21) . Possibly, the GG genotype could raise IL-6 production and/ or secretion, or the C allele could protect against NP and asthma by decreasing inflammation, then playing a role in chronic inflammation found in both diseases (2,(19)(20)(21) .…”

Section: Introductionsupporting

confidence: 81%

“…In our previous study, the frequency of GG genotype was found to be higher in NP patients than in controls (2) and similar results were found in asthma patients (20,21) . Possibly, the GG genotype could raise IL-6 production and/ or secretion, or the C allele could protect against NP and asthma by decreasing inflammation, then playing a role in chronic inflammation found in both diseases (2,(19)(20)(21) . No studies exploring this SNP in NP with asthma were found.…”

Section: Introductionsupporting

confidence: 81%

“…Other studies have already found a GG genotype predominance in asthma-only (20,21) and in NP-only (2) , but this is the first report relating this SNP to NP with asthma.…”

Section: Discussionmentioning

confidence: 48%

“…Only Trajkov et al (21) found the same pattern of non-GG genotype predominance in controls and GG genotype predominance in asthmatics. Settin et al (20) and Mahdaviani et al (33) reported non-GG genotype predominance in controls and asthmatics, although only Settin et al (20) found a difference between groups (GG genotype was more frequent in asthmatics than in controls).…”

Section: Discussionmentioning

confidence: 95%

See 4 more Smart Citations

Interleukin-6 –174 G/C promoter gene polymorphism in nasal polyposis and asthma

Kosugi¹,

Camargo-Kosugi²,

Hirai³

et al. 2013

Rhin

View full text Add to dashboard Cite

SummaryBackground: Interleukin-6 (IL-6) is an inflammatory mediator linked to nasal polyposis and asthma, with a single nucleotide polymorphism -174 G/C that seems to promote an inflammatory status. We aimed to analyze the relationship between this polymorphism and asthmatic nasal polyposis patients. Methodology:Cross-sectional study to investigate IL-6 -174 G/C genotypes of 45 nasal polyposis with asthma patients, 63 nasal polyposis-only patients, 45 asthma-only patients and 81 subjects without both diseases. Aspirin intolerance and atopy were main exclusion criteria. IL-6 genotyping was performed using the PCR method with specific primers followed by restriction enzyme analysis, classifying patients in GG, GC or CC genotype. Results:The GG genotype was the most frequent in all inflammatory groups. Less than 40% of controls presented with the GG genotype. There were significant differences between inflammatory groups and control group. No significant differences were seen when comparing inflammatory groups to each other, other than between nasal polyposis-only group and asthma-only group. Conclusion:The IL-6 74 GG genotype was found more frequently in all inflammatory groups than in controls. This genotype could influence nasal polyposis and asthma, and seems to be more important in the latter.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Introductionsupporting

confidence: 81%

Section: Introductionsupporting

confidence: 81%

“…Other studies have already found a GG genotype predominance in asthma-only (20,21) and in NP-only (2) , but this is the first report relating this SNP to NP with asthma.…”

Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 95%

See 3 more Smart Citations

Interleukin-6 –174 G/C promoter gene polymorphism in nasal polyposis and asthma

Kosugi¹,

Camargo-Kosugi²,

Hirai³

et al. 2013

Rhin

View full text Add to dashboard Cite

show abstract

Cytokine gene polymorphism and asthma susceptibility, progress and control level

et al. 2011

View full text Add to dashboard Cite

Asthma is a multifactor inflammatory disorder, and its management requires understanding of its various pathogenesis and control mechanisms. Cytokines and other inflammatory mediators are important factors in asthma pathophysiology. In this study, we evaluated the role of cytokine polymorphisms in the asthma susceptibility, progress, control, and lung functions. IL-4-C590T polymorphism by PCR-RFLP method, IFN-γ T+874A, TNF-α-A308G, IL-6 G-174C and TGF-β T+869C variants by ARMS-PCR method and IgE serum level by ELISA technique were determined in 81 asthmatic patients and 124 normal subjects. Asthma diagnosis, treatment and control levels were considered using standard schemes and criteria. TNF-α-308GA genotype was more frequent in asthmatics (P = 0.025, OR 3.352), and polymorphisms between different asthma control levels (P > 0.05) were not different. IFN-γ+874AT genotype had a positive correlation with the familial history of asthma (P = 0.034, OR 2.688). IL-6-174C allele (P = 0.045), TNF-α-308GG genotype (P = 0.002) and TNF-α-308G allele (P = 0.004) showed reduced values, and TNF-α-308GA genotype (P = 0.002) increased FEF25-75 value in asthmatics. IFN-γ+874AA genotype caused a decrease in FVC factor (P = 0.045). This study showed that TNF-α-308GA is a risk factor for asthma, but cytokine gene variants do not affect asthma control and IgE serum levels. Variants producing lower levels of IL-6, TNF-α and IFN-γ are associated with reduced pulmonary capacities. To achieve an appropriate schema for asthma management, further studies with consideration of different aspects in a larger group of patients would be more elucidative.

show abstract

Interleukin-18 −607C/A Gene Polymorphism in Egyptian Asthmatic Children

et al. 2014

View full text Add to dashboard Cite

No significant statistical difference was encountered regarding the distribution of IL-18 -607C/A genotypes and allele frequencies in asthma patients and healthy controls. Also, there were no significant associations between asthma severity and different genotypes or alleles. The median value of the total serum IgE level in asthmatic cases with the mutant genotype (AA) was significantly higher than in the control group. Thus, IL-18 -607AA genotype frequency might be related to higher total serum IgE.

show abstract

Gene polymorphisms of IL-6−174 G/C and IL-1Ra VNTR in asthmatic children

Abstract: IL-6 and IL-1Ra polymorphisms can be considered genetic markers for bronchial asthma susceptibility and/or severity among Egyptian children. This may have a potential impact on family counseling and management.

Cited by 25 publications

References 18 publications

Interleukin-6 –174 G/C promoter gene polymorphism in nasal polyposis and asthma

Interleukin-6 –174 G/C promoter gene polymorphism in nasal polyposis and asthma

Cytokine gene polymorphism and asthma susceptibility, progress and control level

Interleukin-18 −607C/A Gene Polymorphism in Egyptian Asthmatic Children

Contact Info

Product

Resources

About