Gene prolactine receptor (PRLR) and signal transducer and activator of transcription 5 (STAT5) on milk production

Iskandar, Imelda; As’ad, Suryani; Mappaware, Nasruddin; Alasiry, Ema; Hendarto, Hendy; Budu,; Hatta, Mochammad; Juliaty, Aidah; Ahmad, Mardiana; Syam, Azniah

doi:10.1016/j.mcpsp.2021.100223

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…Although the study did not establish a causal relationship between nutritional status and postpartum depression, mothers with a BMI in the excessive weight category are at risk of producing less breast milk [40] and discontinuing breastfeeding sooner [41]. Healthy nutritional status before pregnancy promotes healthy fetal development.…”

Section: Discussionmentioning

confidence: 86%

“…Additionally, it was reported in the same study that a deficiency of Omega 3 fatty acids involved in the production of DHA is a risk factor for developing an imbalance in the regulation of the HPA axis [43]. Although the study was unable to establish a causal relationship between nutritional status and postpartum depression, mothers with a BMI of overweight to obesity are at risk of producing less breast milk volume [40,44], as well as discontinuing breastfeeding earlier [41]. Macro and micronutrient deficiency history increased the risk of weak fetal growth and birth outcomes [45].…”

Section: Discussionmentioning

confidence: 94%

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Marital Age, Cigarette Exposure, Physical Activity, Sleep Duration, and Prenatal Depression

Syam

Abrar

et al. 2022

Dis.Prev.Public Heal J.

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Background: Extensive studies indicate that prenatal depression disrupts a woman's life and has a detrimental effect on the mother-child and further breastfeeding. Numerous factors associated with nutrition, physical activity, sleep patterns, and exposure to cigarette smoke are strongly suspected of contributing to the dysregulation of hormones associated with depression. This study aims to examine the association between physical activity, nutritional status, prior exposure to cigarette smoke, and the risk of prenatal depression. Method: A cross-sectional study was conducted on 79 pregnant women at the Pampang Primary Healthcare Center between January and March 2021. Using chi-square and multiple logistic regression, identify the risk factors that most significantly contribute to the risk of prenatal depression. Result: Married under the age of 19th (p<0.039), inactive daily exercise (p<0.023), inadequate sleep duration (p<0.045), and mothers who have been exposed to cigarette smoke for more than a year (p<0.001) all increased the risk of prenatal depression. Cigarette exposure, contributes most, with a 5.4-fold increased risk of developing mental disorders while breastfeeding. Conclusion: It is critical for health services to include early screening for prenatal depression during antenatal care as a means of preventing future breastfeeding difficulties, particularly in mothers with vulnerability.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 94%

Marital Age, Cigarette Exposure, Physical Activity, Sleep Duration, and Prenatal Depression

Syam

Abrar

et al. 2022

Dis.Prev.Public Heal J.

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“…In addition, prolactin may contribute to stress control through downregulation of prolactin receptors in lactating mice [44]. Expression of the prolactin receptor gene was also found to be higher in mothers who had more breastmilk volume and breastfeeding intensity [45], [46]. Downregulation of prolactin receptors enhances responses to anxiety through the increase in ACTH release; however, administration of prolactin to female rats causes hyperprolactinemia, giving anxiolytic effects and triggering the suppression of ACTH, corticosterone, and noradrenaline [47].…”

Section: Discussionmentioning

confidence: 99%

Cortisol, Prolactin, and Breastmilk Volume; A Promising Pattern for Reducing Postpartum Depression

Syam¹,

Qasim

Iskandar

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Research shows postnatal depression and shorter breastfeeding are consistently related, but their causal effect remains debatable. To reduce the impact of mental disorders in the perinatal period, lactation may give a significant neuroendocrine effect. AIM: This study aimed to examine hormonal patterns and estimated breastmilk volume of mothers with depression. MATERIALS AND METHODS: This study was conducted during the three-trimester to 6-week postnatal period. It involved 60 pregnant women from South Sulawesi, Indonesia. Analysis of variance with repeated measures was used to compare and review fluctuations and effect sizes of cortisol, prolactin, and breastmilk volume of mothers with depression symptoms. RESULTS: The mean cortisol levels rose in the 4th week and decreased in the 6th week in both groups. There was no substantial difference in the cortisol levels between these periods (p = 0.534; p = 0.553; and p = 0.660), but the prolactin levels continuously increased by 2 weeks and substantially progressed in the 4th and 6th weeks (p < 0.028, p < 0.009), respectively. There was no positive association between cortisol and prolactin levels (p = 0.384). The breastmilk volume was higher every week only in mothers without depression and it slightly decreased in other categories. This study emphasized the prolactin’s protective effect size on a stressful environment characterized by high cortisol; a significant rise in prolactin levels occurred in the 2nd and 4th weeks of postnatal, marking the higher lactation. CONCLUSIONS: Breastfeeding hormones may provide protection against postpartum depression in moms. It is critical to establish a history of prior trauma in nursing mothers in order to facilitate diagnosis and proper care.

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“…On average, breast milk was obtained by dividing the volume on days 1, 3, and 8 by dividing by three [15]. The volume of breast milk was then categorized into two, according to the former research [22]. i) It is optimal if the volume of breast milk production is≥ 440 ml per day.…”

Section: Interventionmentioning

confidence: 99%

The effectiveness of moringa leaf jelly on mother's prolactin level and baby's outcome

Marsiami,

Puspariny

2024

IJPHS

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The failure of exclusive breastfeeding and the increased use of milk formulas is one of the results of a shortage of breast milk production. Moringa leaf contains phytosterol to increase milk production. Fortification of moringa leaf with jelly will increase the nutritional value of moringa leaf so that the prolactin increases and the production and quality of breast milk get better for babies. This study aimed to determine the effect of moringa leaf jelly on increasing milk production (prolactin, breast milk volume), and the outcome for the baby. Quasi-experimental research using pre-postest with control group design. The study respondents were taken with a purposive sampling technique of 58 people. Outcome indicators for babies are seen from the baby’s weight, the baby's urination frequency, the baby's defecation, and the baby's sleep duration. There was a significant effect on the increase in prolactin score by 23.3%, breast milk volume by 47%, and outcome babies by 3.3% in respondents given moringa leaf jelly. Meanwhile, respondents who were not given Moringa leaf jelly had a risk of decreasing prolactin levels 10.5 times, breast milk supply was 3.8 times lower and the outcomes for babies were 15 than those given Moringa leaf jelly. The moringa leaf jelly significantly effects increasing milk production and outcomes for babies compared to standard interventions.

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Gene prolactine receptor (PRLR) and signal transducer and activator of transcription 5 (STAT5) on milk production

Cited by 6 publications

References 25 publications

Marital Age, Cigarette Exposure, Physical Activity, Sleep Duration, and Prenatal Depression

Marital Age, Cigarette Exposure, Physical Activity, Sleep Duration, and Prenatal Depression

Cortisol, Prolactin, and Breastmilk Volume; A Promising Pattern for Reducing Postpartum Depression

The effectiveness of moringa leaf jelly on mother's prolactin level and baby's outcome

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