Gene therapy for spinal fusion

Phillips, Frank M.; Bolt, Patrick; He, Tong‐Chuan; Haydon, Rex C.

doi:10.1016/j.spinee.2005.02.015

Cited by 15 publications

(10 citation statements)

References 98 publications

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“…Most promising however are developments in cervical arthroplasty [64] and the ultimate possibilities of gene therapy [70]. However, current and emerging graft technologies must be treated with caution and a view for economic-effectiveness.…”

Section: Resultsmentioning

confidence: 99%

Bone graft substitutes in anterior cervical discectomy and fusion

2009

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Anterior cervical discectomy with fusion is a common surgical procedure for patients suffering pain and/ or neurological deficits and unresponsive to conservative management. For decades, autologous bone grafted from the iliac crest has been used as a substrate for cervical arthrodesis. However patient dissatisfaction with donor site morbidity has led to the search for alternative techniques. We present a literature review examining the progress of available grafting options as assessed in human clinical trials, considering allograft-based, synthetic, factor-and cell-based technologies.

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Section: Resultsmentioning

confidence: 99%

Bone graft substitutes in anterior cervical discectomy and fusion

2009

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“…While the absolute results in this study are specific to the femoral stem design used, this general result should extrapolate to other polished, collarless, tapered femoral stem designs (such as the Exeter). Against the backdrop of spiraling health costs, a disadvantage of currently available biologically active factors is their considerable expense [29][30][31]. The use of these factors, when deemed appropriate to enhance MCB fusion, might therefore be economized by preferentially applying them to MCB that will be impacted into the proximal portion of the graft.…”

Section: Discussionmentioning

confidence: 99%

Stability Differentials for Proximal vs Distal Fusion of Total Hip Arthroplasty Femoral Impaction Grafts

Heiner¹,

Callaghan²,

Brown³

2008

The Journal of Arthroplasty

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In impaction grafting for revision joint arthroplasty, the morselized cancellous bone (MCB) ideally remodels into a new contiguous lattice. However, the use of biologically active factors may sometimes be indicated to enhance fusion. The purpose of this study was to determine the stability of femoral impaction graft constructs for which either only the proximal or distal half of the MCB volume was modeled as fused. Fusing the proximal half of the impaction graft volume resulted in a higher femoral stem stability than did fusing the distal half. This proximal graft fusion also resulted in a stem stability that was similar to that of fusing the entire graft. These results emphasize the importance of proximal fixation of an impaction grafted femoral stem.

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“…This technique has also been applied to other areas including osteoporosis, aseptic loosening, genetic diseases, musculoskeletal infections, and tumors 74–77. Spinal fusions and repair of segmental defects of long bones have seen impressive preclinical study results 717374…”

Section: Biological Methods To Facilitate Bone Healing and Repairmentioning

confidence: 99%

Global burden of trauma: Need for effective fracture therapies

George¹,

Hanson²

2009

Indian J Orthop

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Orthopedic trauma care and fracture management have advanced significantly over the last 50 years. New developments in the biology and biomechanics of the musculoskeletal system, fixation devices, and soft tissue management have greatly influenced our ability to care for musculoskeletal injuries. Many therapies and treatment modalities have the potential to transform future orthopedic treatment by decreasing invasive procedures and providing shorter healing times. Promising results in experimental models have led to an increase in clinical application of these therapies in human subjects. However, for many modalities, precise clinical indications, timing, dosage, and mode of action still need to be clearly defined. In order to further develop fracture management strategies, predict outcomes and improve clinical application of newer technologies, further research studies are needed. Together with evolving new therapies, the strategies to improve fracture care should focus on cost effectiveness. This is a great opportunity for the global orthopedic community, in association with other stakeholders, to address the many barriers to the delivery of safe, timely, and effective care for patients with musculoskeletal injuries in developing countries.

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Gene therapy for spinal fusion

Cited by 15 publications

References 98 publications

Bone graft substitutes in anterior cervical discectomy and fusion

Bone graft substitutes in anterior cervical discectomy and fusion

Stability Differentials for Proximal vs Distal Fusion of Total Hip Arthroplasty Femoral Impaction Grafts

Global burden of trauma: Need for effective fracture therapies

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