Gene Therapy in Orthotopic Lung Cancer Murine Model with Angiogenesis Inhibitor, Endostatin

Host Deficiency in Vav2/3 Guanine Nucleotide Exchange Factors Impairs Tumor Growth, Survival, and Angiogenesis In vivo

“…In addition, there was a significant decrease in microvascular density in tumors from Vav2/3-deficient mice versus wild-type controls (Figure 1D). These results are consistent with other studies involving anti-angiogenic therapy in orthotopic LLC tumors, in which increased apoptosis, but not proliferation, was observed (33), suggesting that these conditions favor apoptotic rather than growth defects.…”

Antiangiogenesis gene armed tumor‐targeting adenovirus yields multiple antitumor activities in human HCC xenografts in nude mice

“…Antiangiogenic therapy attempts to stop new vessels from forming around tumors and to break up the existing network of abnormal capillaries that feed the cancerous mass. Endostatin, a 20-kDa C-terminal fragment of collagen XVIII, is the most potent angiogenesis inhibitor and specifically inhibits endothelial cell proliferation and migration, induces apoptosis of vascular endothelial cells, [17][18][19] and has been demonstrated to be with antitumor effect in many solid tumors.…”

The Attitude of Oncology Physicians and Nurses to the Acceptance of New Drugs for Gene Therapy

“…The basic goal of cancer gene therapy is to insert genes into cancer cells and tissues to inhibit the unchecked growth of tumour and to prevent angiogenesis and metastasis [7][8][9]. Cancer gene therapy can also improve the efficacy of chemotherapy and radiotherapy [10,11].…”