Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg

Abstract

Objective: Monocyte chemoattractant protein 1 (MCP-1) has been suggested to be involved in the development of several components of metabolic syndrome (MetS). The present study investigated the association of nine MCP-1 single nucleotide polymorphisms (SNPs) with MetS, type 2 diabetes mellitus and metabolic risk factors. Subjects and methods: The population-based study sample comprised 1630 subjects aged 55-74 years from KORA S4 (Cooperative Health Research in the Region of Augsburg Survey 4). Genotyping was carried out by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis of alleledependent primer extension products. Results: The MCP-1 SNP c.-3813COT exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid (PZ0.0084, 0.014, 0.027). Other trends were observed for c.-928GOC associated with height and fasting glucose (PZ0.0024, 0.033), for c.105TOC with height and leukocytes (PZ0.0095, 0.047), for c.*65COT and c.*3879COT with MCP-1 levels (both PZ0.012) and for c.-2138AOT with interleukin-6 levels. After correction for multiple testing, none of the analysed SNPs, except c.-928GOC in men showed a significant association with MetS, T2DM or other analysed parameters. Haplotype MCP-1*1 and c.-928GOC in men (PZ0.0002, 0.0004) were significantly associated with an increase in height. Conclusions: This is the first study to investigate the associations of MCP-1 SNPs with MetS. We found trends for several components of MetS. These parameters were hyperlipidaemia, fasting and 2-h glucose, and uric acid. A new finding is that MCP-1*1 haplotype is associated with height. Further investigation in larger populations is needed to clarify the involvement of MCP-1 in MetS.

Association of Monocyte Chemoattractant Protein-1 −2518 Polymorphism With Metabolic Syndrome in a South Indian Cohort

“…The fi rst and the only study concerning MCP-1 SNPs and metabolic syndrome in a German population by Sedlmeier et al has reported association trends for several components of metabolic syndrome, including TG levels and fasting glucose with MCP-1 SNPs. 19 In our study cohort, we observed an association of the MCP-1 -2518G allele with metabolic syndrome that also remained significant in a dominant genetic model. Genetic analysis with individual metabolic syndrome components indicated that WC or the obesity component of metabolic syndrome is the major phenotype associated with the MCP-1 -2518G allele.…”

Monocyte chemoattractant protein‐1 gene polymorphism and its serum level have an impact on anthropometric and biochemical risk factors of metabolic syndrome in Indian population

“…Several genetic association studies reported association with MCP-1 gene polymorphism with obesity, diabetes and individual risk factors of MetS (Simeoni et al, 2004;Kouyama et al, 2008;Szalai et al, 2001). Some genetic studies reported association of MCP-1 polymorphism with MetS subjects (Kaur et al, 2009;Sedlmeier et al, 2007). However, association of the single nucleotide polymorphism (SNP) À2518A>G with metabolic disorders is controversial.…”

Genetics of metabolic syndrome

“…Examination of the IL6 -174G>C promoter polymorphism in 571 whites revealed a higher MetS prevalence among those with the CC genotype [37]. Conversely, a population-based sample of 1630 Germans revealed that none of the seven SNPs of the proinflammatory cytokine MCP1 gene were associated with MetS [38]. Meanwhile, although a meta-analysis of 31 studies revealed that the TNFA -308G>A polymorphism conferred a risk of 1.23 for obesity and an increase in systolic blood pressure by 3.5 mm Hg, it was not examined in relation to MetS [39].…”