General and programmable synthesis of hybrid liposome/metal nanoparticles

Lee, Jinho; Shin, Yong‐Cheol; Lee, Wooju; Whang, Keumrai; Kim, Dongchoul; Lee, Luke P.; Choi, Jeong‐Woo; Kang, Taewook

doi:10.1126/sciadv.1601838

Cited by 61 publications

(59 citation statements)

References 50 publications

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“…Unilamellar liposomes were purified by centrifugation and washed three times with deionized water to remove residues. Finally, the liposomes encoded with ascorbic acid and CoQ10 were re-suspended using a gold precursor aqueous solution (HAuCl 4 •3H 2 O, tetrachloroauric acid trihydrate, 200 μM) and kept overnight in an agitating incubator at room temperature [24]. The LGNP-CoQ10 structure is shown in Figure 1A.…”

Section: Formation Of Lgnp-coq10mentioning

confidence: 99%

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

Jhun

Moon

Ryu

et al. 2020

Preprint

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Background: Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble antioxidant. Although CoQ10 has not been approved as medication by the Food and Drug Administration, it is widely used in dietary supplements. Some studies have shown that CoQ10 has anti-inflammatory effects on various autoimmune disorders.Methods: In this study, we investigated the anti-inflammatory effects of liposome/gold hybrid nanoparticles encoded with CoQ10 (LGNP-CoQ10). Both CoQ10 and LGNP-CoQ10 were administered orally to mice with collagen-induced arthritis (CIA) for 10 weeks. The inflammation pathology of joint tissues of CIA mice was then analyzed using hematoxylin and eosin and Safranin O staining, as well as immunohistochemistry analysis. We obtained immunofluorescence staining images of spleen tissues using confocal microscopy.Results: We found that pro-inflammatory cytokines were significantly decreased in LGNP-CoQ10 injected mice. Th17 cell and phosphorylated STAT3-expressed cell populations were also decreased in LGNP-CoQ10 injected mice. When human peripheral blood mononuclear cells (PBMCs) were treated with CoQ10 and LGNP-CoQ10, the IL-17 expression of PBMCs in the LGNP-CoQ10-treated group was significantly reduced.Conclusion: These results suggest that LGNP-CoQ10 has therapeutic potential for the treatment of rheumatoid arthritis.

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Section: Formation Of Lgnp-coq10mentioning

confidence: 99%

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

Jhun

Moon

Ryu

et al. 2020

Preprint

Self Cite

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“…Nowadays, to overcome these limitations, hybrid systems have begun to attract attention. The use of vesicles in such systems has improved their colloidal stability and intracellular delivery efficiency . Nanoparticles in vesicular hybrid systems should be embedded within the bilayer.…”

Section: Hybrid Vesicular Delivery Systemsmentioning

confidence: 99%

Hybrid Vesicular Drug Delivery Systems for Cancer Therapeutics

Mohammadi

Taghavi

Abnous

et al. 2018

Adv Funct Materials

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Nanoscale vesicles have provided a versatile platform for the transportation of various types of anticancer and diagnostic agents. Vesicular carriers comprised of liposomes, polymersomes, and peptide-based vesicles have exhibited potential characteristics for nanomedicine developments. However, the represented systems and current therapeutic approaches to cancers are confronted with serious limitations that hinder their clinical translation. The aforementioned limitations could be minimized by implementing combinatorial hybrid systems. With this method, hybrid vesicular systems can integrate the advantages of several carriers into one structure thereby resulting in an increased therapeutic index and better clinical outcome. The current study has reviewed recently introduced types of hybrid vesicles made of polymer-lipids, polymer-peptides, and lipid-peptides, and its main focus is on multiple metallic-based nanoparticles incorporated into vesicular carriers to provide theranostic platforms and to boost the efficient cytotoxic effects of the delivered agents.

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“…These liposomes can produce stronger photoacoustic signals (1.5-fold) in the NIR region than blood. Furthermore, when there were drugs (i.e., doxorubicin (Dox)) within these liposomes, the irradiation with the NIR pulse laser would disrupt the liposomes and trigger the 100% release of these pre-encapsulated drugs within 10 s. Recently, Lee et al [ 20 ] further demonstrated that the reducing agent could be re-encoded before the metal precursors diffused across lipid bilayers self-crystallized to metal nanoparticles in the liposomes.…”

Section: Synthesis Of Gold Nanoparticle-liposomesmentioning

confidence: 99%

A Concise Review of Gold Nanoparticles-Based Photo-Responsive Liposomes for Controlled Drug Delivery

2017

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The focus of drug delivery is shifting toward smart drug carriers that release the cargo in response to a change in the microenvironment due to an internal or external trigger. As the most clinically successful nanosystem, liposomes naturally come under the spotlight of this trend. This review summarizes the latest development about the design and construction of photo-responsive liposomes with gold nanoparticles for the controlled drug release. Alongside, we overview the mechanism involved in this process and the representative applications.

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General and programmable synthesis of hybrid liposome/metal nanoparticles

Abstract: Programmable liposomes are designed to selectively produce various liposome-nanoparticle hybrids.

Cited by 61 publications

References 50 publications

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting

Hybrid Vesicular Drug Delivery Systems for Cancer Therapeutics

A Concise Review of Gold Nanoparticles-Based Photo-Responsive Liposomes for Controlled Drug Delivery

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