General Applications of Schiff Bases and Their Metal Complexes

Singh, Anmol; Gogoi, Himadri Priya; Barman, Pranjit

doi:10.1002/9783527839476.ch13

Cited by 3 publications

(2 citation statements)

References 39 publications

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“…25−28 Schiff bases are broadly used in many industrial fields as dyestuffs, pigments, catalysts, corrosion inhibitors, and polymer stabilizers in addition to their pharmacological properties. 29 Diabetes mellitus, also known as a chronic disorder, happens due to a deficiency of insulin production in the body. Increased blood glucose levels are an emerging feature of this disease, which can harm various physiological systems, including blood vessels and nerves.…”

Section: Introductionmentioning

confidence: 99%

New 1,3,4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies

Ali,

Rehman,

Rasheed

et al. 2024

ACS Omega

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Diabetes is an emerging disorder in the world and is caused due to the imbalance of insulin production as well as serious effects on the body. In search of a better treatment for diabetes, we designed a novel class of 1,3,4-thiadiazole-bearing Schiff base analogues and assessed them for the α-glucosidase enzyme. In the series (1−12), compounds are synthesized and 3 analogues showed excellent inhibitory activity against αglucosidase enzymes in the range of IC 50 values of 18.10 ± 0.20 to 1.10 ± 0.10 μM. In this series, analogues 4, 8, and 9 show remarkable inhibition profile IC 50 2.20 ± 0.10, 1.10 ± 0.10, and 1.30 ± 0.10 μM by using acarbose as a standard, whose IC 50 is 11.50 ± 0.30 μM. The structure of the synthesized compounds was confirmed through various spectroscopic techniques, such as NMR and HREI-MS. Additionally, molecular docking, pharmacokinetics, cytotoxic evaluation, and density functional theory study were performed to investigate their behavior.

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Section: Introductionmentioning

confidence: 99%

New 1,3,4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies

Ali,

Rehman,

Rasheed

et al. 2024

ACS Omega

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“…Over many years, thiosemicarbazide has been the strong intermediate for developing various novel biomaterials and, therefore, widely utilized in pharmaceutical and medicinal industries. [2,3] The significant biological action [4][5][6][7][8] provided the driving force for exploring the coordination chemistry of these potent ligands. These ligands were also commercially used as analytic reagents, [9,10] catalyst, [11][12][13] molecular-magnetic material, [14] spin-crossover materials, [15] chemosensor to detect Hg 2 + ions, [16] fluoride anions and inorganic cations.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Thiosemicarbazone Coordination Metal Complexes: Synthesis, Characterization, Theoretical analysis, Biological Activity, Molecular Docking and ADME analysis**

Jain

Vishvakarma²,

Singh

et al. 2023

Chemistry & Biodiversity

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Mn(II) and Cu(II) complexes having the formula [M(L)2]X2 of ligand, i. e., 2‐acetyl‐5‐methylfuranthiosemicarbazone were synthesized. Various analytical and spectroscopic techniques described the structure of synthesized complexes. Molar conductance confirmed the electrolytic nature of the complexes. The theoretical study of the complexes explained the structural property and reactivity. The chemical reactivity, interaction and stability of the ligand and metal complexes were studied with the help of global reactivity descriptors. MEP analysis was used to investigate the charge transfer in the ligand. The biological potency was evaluated against two bacteria and two fungi. Complexes demonstrated superior inhibitory action to ligand. The inhibitory effect was also checked at the atomic scale using molecular docking, which confirmed the experimental results. Cu(II) complex was shown to have the most inhibitory effect in experimental and theoretical studies. To check the bioavailability and drug‐likeness, ADME analysis was also done.

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Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity

Richa,

Kumar,

Kataria

2024

Journal of Inorganic Biochemistry

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General Applications of Schiff Bases and Their Metal Complexes

Cited by 3 publications

References 39 publications

New 1,3,4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies

New 1,3,4-Thiadiazole Derivatives as α-Glucosidase Inhibitors: Design, Synthesis, DFT, ADME, and In Vitro Enzymatic Studies

Bioactive Thiosemicarbazone Coordination Metal Complexes: Synthesis, Characterization, Theoretical analysis, Biological Activity, Molecular Docking and ADME analysis**

Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity

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