2019
DOI: 10.1016/j.arth.2018.09.070
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General Assembly, Diagnosis, Laboratory Test: Proceedings of International Consensus on Orthopedic Infections

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Cited by 25 publications
(14 citation statements)
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“…[21]. According to the conflicting results reported, no clear recommendation on the usefulness can be made [22]. A trend can be seen towards increased specificity with reduced sensitivity when comparing the mentioned results with our own multi-biomarker findings.…”
Section: Discussionmentioning
confidence: 84%
See 1 more Smart Citation
“…[21]. According to the conflicting results reported, no clear recommendation on the usefulness can be made [22]. A trend can be seen towards increased specificity with reduced sensitivity when comparing the mentioned results with our own multi-biomarker findings.…”
Section: Discussionmentioning
confidence: 84%
“…Bottner et al reported high sensitivity and specificity for PJI detection both for CRP (95 and 96%) and IL-6 (95 and 87%) while their combination lead to a sensitivity of 100% and a specificity of 86% [ 21 ]. According to the conflicting results reported, no clear recommendation on the usefulness can be made [ 22 ]. A trend can be seen towards increased specificity with reduced sensitivity when comparing the mentioned results with our own multi-biomarker findings.…”
Section: Discussionmentioning
confidence: 99%
“…Although it is traditionally considered a laboratory inflammation indicator, the process of erythrocyte sedimentation is influenced by other numerous physiological and pathophysiological factors, most significant being anemia, alterations in RBC morphology, and presence of paraproteins, thus limiting its utility in inflammatory conditions . With the introduction of more specific inflammatory biomarkers, its usefulness has decreased and nowadays ESR remains helpful in the diagnosis and monitoring of a limited number of clinical conditions, in particular rheumatoid diseases, orthopedic infections, and Hodgkin's lymphoma …”
Section: Introductionmentioning
confidence: 99%
“…is influenced by other numerous physiological and pathophysiological factors, most significant being anemia, alterations in RBC morphology, and presence of paraproteins, thus limiting its utility in inflammatory conditions. 5 With the introduction of more specific inflammatory biomarkers, its usefulness has decreased and nowadays ESR remains helpful in the diagnosis and monitoring of a limited number of clinical conditions, in particular rheumatoid diseases, 8 orthopedic infections, 9 and Hodgkin's lymphoma. 10 The International Council for Standardization in Haematology (ICSH) defines the Westergren method originally introduced in 1921 as the gold standard method for ESR determination.…”
mentioning
confidence: 99%
“…Thus, to date, ongoing investigations are focused on the establishment of appropriate methods for prompt and precise diagnosis of PJIs. Despite the wide range of available diagnostic tests, diagnostic performance varies, and no adequate sensitivity and sensibility have been achieved 6,7 . In an effort to establish a standard and effective diagnostic algorithm for patients suspected of PJI, the Musculoskeletal Infection Society (MSIS) recommended a panel of clinical and laboratory parameters, 8 modified in 2013 by the International Consensus Meeting (ICM), 9 to standardize the classification of PJIs.…”
Section: Introductionmentioning
confidence: 99%