General characteristics of an early arthritis cohort in Argentina

Marcos, Juan Carlos; Waimann, Christian A.; Pra, Fernando Dal; Hogrefe, J.; Retamozo, Soledad; Caeiro, Francisco; Casalla, Luciana; Benegas, Mariana; Rillo, Oscar; Spindler, Alberto; Berman, Horacio; Berman, Alberto; Secco, Anastasia; Salinas, Rodrigo García; Pellet, Antonio Catalán; Ceccato, Federico; Paira, Sergio; Marcos, Josefina; Cocco, J. A. Maldonado; Citera, Gustavo

doi:10.1093/rheumatology/keq220

Cited by 24 publications

(21 citation statements)

References 30 publications

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“…3,22,23 A perda de capacidade funcional ocorre já no início da doença, com a presença de inflamação aguda. 24 Com o uso precoce de DMARDs, ao se obter controle sobre a atividade da doença, há uma recuperação funcional, seguida por lesões estruturais que se instalam lenta e cumulativamente. A deterioração funcional, dessa forma, pode ocorrer antes mesmo das alteraç ões radiológicas, as quais se tornam relevantes após cinco anos do início da doença.…”

Section: Discussionunclassified

“…7,20 Existe uma correlação inversa entre a pontuação do HAQ e as ADM de algumas articulaç ões como punhos, ombros e joelhos. 24 O EPM-ROM leva em conta as faixas de ADM necessárias para se realizar variadas funç ões, e não simplesmente uma porcentagem de perda de amplitude causada pela doença, que pode ser diferente de acordo com as articulaç ões. 8 Nossos dados evidenciam a esperada correlação da avaliação inicial do EPM-ROM com o número de articulaç ões inflamadas.…”

Section: Discussionunclassified

“…Ainda não está claro se são as medicaç ões biológicas que reduzem a necessidade de indicação cirúrgica nos pacientes com AR. 24,25,29 De uma forma geral, é sabido que o uso precoce de DMARDs na AR tende a diminuir a progressão da doença, melhorar qualidade de vida, e também reduzir custos com internaç ões, procedimentos cirúrgicos e períodos longos de reabilitação. 11,30 Nossos dados demonstram que a pontuação do HAQ e do EPM-ROM num grupo de pacientes com AR atendido em Serviço Público não se alterou ao longo do período médio de três anos.…”

Section: Discussionunclassified

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Acompanhamento da capacidade funcional de pacientes com artrite reumatoide por três anos

Oliveira

Natour

Roizenblatt

et al. 2015

Revista Brasileira de Reumatologia

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In a group of RA patients in use of only MTX as DMARD, there was little change on HAQ score and EPM-ROM scores over the average period of three years. Worsening functional capacity was observed in the group of operated patients in comparison to the not operated ones. This fact alerts us to the need for use of broader therapeutic regimens availability of musculoskeletal surgeries in a timely manner in patients with RA.

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Section: Discussionunclassified

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Acompanhamento da capacidade funcional de pacientes com artrite reumatoide por três anos

Oliveira

Natour

Roizenblatt

et al. 2015

Revista Brasileira de Reumatologia

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“…3,22,23 The loss of functional capacity occurs early in the disease, with the presence of acute inflammation. 24 With the early use of DMARDs and after controlling the disease activity, a functional recovery occurs, followed by structural lesions that settle slowly and cumulatively. Thus, the functional deterioration may occur even before the radiographic changes, which become relevant after a lapse of five years from the onset of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…wrists, shoulders and knees, was observed. 24 EPM-ROM takes into account the ROM ranges needed to perform wide-ranging functions, and not just a percentage of amplitude loss caused by the disease, which can differ depending on the joint. 8 Our data show the expected correlation between the baseline evaluation by EPM-ROM and the number of inflamed joints.…”

Section: Discussionmentioning

confidence: 99%

Monitoring the functional capacity of patients with rheumatoid arthritis for three years

Oliveira

Natour

Roizenblatt

et al. 2015

Revista Brasileira de Reumatologia (English Edition)

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r e v b r a s r e u m a t o l . 2 0 1 5;5 5(1):62-67 REVISTA BRASILEIRA DE REUMATOLOGIA w w w . r e u m a t o l o g i a . c o m . b r a b s t r a c t Objective: To quantify modification of functional capacity in a three-year period in a group of patients with rheumatoid arthritis (RA) using HAQ and EPM-ROM inventories.Methods: Forty patients with RA on methotrexate (MTX) as disease-modifying antirheumatic drug (DMARD) were followed for up to three years. The functional status was assessed at the beginning and end of the period by HAQ and EPM-ROM.Results: Thirty-two patients were retrieved, with initial HAQ score of 1.14 ± 0.49 (mean ± SD) and EPM-ROM score of 5.8 ± 2.75. After an average period of three years, the HAQ score was 1.13 ± 0.49 and EPM-ROM score, 6.81 ± 3.66. In the subgroup of seven patients submitted to orthopedic surgery, HAQ score decreased from 0.84 ± 0.72 to 1.64 ± 0.56 and the EPM-ROM score, from 5.8 ± 1.80 to 8.3 ± 0.74. In the subgroup of non-operated patients, HAQ score varied from 1.2 ± 0.45 to 1.07 ± 0.70 and EPM-ROM score, from 5.7 ± 3.06 to 6.4 ± 3.90. Conclusion: In a group of RA patients in use of only MTX as DMARD, there was little change on HAQ score and EPM-ROM scores over the average period of three years. Worsening functional capacity was observed in the group of operated patients in comparison to the not operated ones. This fact alerts us to the need for use of broader therapeutic regimens availability of musculoskeletal surgeries in a timely manner in patients with RA. Acompanhamento da capacidade funcional de pacientes com artrite reumatoide por três anos Palavras-chave: Artrite reumatoide Capacidade funcional HAQ EPM-ROM r e s u m o Objetivo: Quantificar a modificação da capacidade funcional em um período de três anos em um grupo de pacientes com artrite reumatoide (AR), utilizando os inventários HAQ e EPM-ROM. Métodos: Quarenta pacientes com AR em tratamento com metotrexato (MTX) como fármaco antirreumático modificador da doença (DMARD) foram acompanhados por até três anos. O estado funcional foi avaliado no início e no final do período por HAQ e EPM-ROM. r e v b r a s r e u m a t o l . 2 0 1 5;5 5(1):62-6763 Resultados: Trinta e dois pacientes foram recuperados, com escore HAQ inicial de 1,14 ± 0,49 (média ± DP) e EPM-ROM de 5,8 ± 2,75. Após um período médio de três anos, o HAQ foi de 1,13 ± 0,49 e EPM-ROM em 6,81 ± 3,66. No subgrupo de sete pacientes submetidos a cirurgia ortopédica, o HAQ diminuiu de 0,84 ± 0,72 para 1,64 ± 0,56; e o EPM-ROM, de 5,8 ± 1,80 para 8,3 ± 0,74. No subgrupo de pacientes não operados, o HAQ variou de 1,2 ± 0,45 para 1,07 ± 0,70; e o EPM-ROM, de 5,7 ± 3,06 para 6,4 ± 3,90. Conclusão: Em um grupo de pacientes com AR medicados apenas com MTX como DMARD, houve pouca mudança nas pontuaç ões HAQ e EPM-ROM durante o período médio de três anos. Observou-se agravamento da capacidade funcional no grupo de pacientes operados, em comparação com os não operados. Este fato nos alerta para a necessidade do uso de esquemas terapêuticos mais abrangentes e de maio...

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Limited Diagnostic and Prognostic Value of Routine Radiographs in Newly Presenting Arthritis Suspected of Rheumatoid Arthritis: A Retrospective Study

Ulijn,

den Broeder,

Ten Cate

et al. 2024

Arthritis Care & Research

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ObjectiveCurrent recommendations suggest that patients with newly presenting arthritis suspected of Rheumatoid Arthritis (RA) should undergo routine radiographs of hands and feet (X‐HF) as the presence of RA‐associated erosions might be of diagnostic and prognostic value. Our objective was investigate the prevalence, diagnostic and prognostic value of RA‐associated erosions seen on routine X‐HF in a large, recent cohort of newly presenting arthritis patients.MethodsA retrospective cohort study was performed between 2016‐2019 in patients with newly presenting arthritis suspected of RA. Patients were included if arthritis was present at diagnosis, Rheumatoid Factor and Anti‐Citrullinated Protein Antibodies were measured, RA was noted in the differential diagnosis, and routine X‐HF were conducted. Outcomes were the prevalence of ≥1 RA‐associated erosion, and whether diagnostic or prognostic classification were changed by erosivity. Seronegative patients, patients without Acute Phase Reactants (APR) and patients with longer symptom duration were analyzed as subgroups.ResultsRA‐associated erosions were found in 32/724 patients (4.4%, CI 3.1‐6.2%). Erosions led to a change of diagnostic classification in two patients (0.3%, 95%CI 0.01‐1.1%) and changed prognostic classification in three patients (0.4%, 95%CI 0.1‐1.3%). Seronegative patients and patients without elevated APR had significantly lower prevalence of erosions (χ2 9.4, P=0.002, χ2 6.5, P=0.01). Longer symptom duration was not associated with a different prevalence of erosions (χ2 0.4, P=0.81).ConclusionThe recommendation of conducting routine X‐HF in patients with newly presenting arthritis suspected of RA might be reconsidered, due to low prevalence of early erosive disease and lack of diagnostic and prognostic value.image

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General characteristics of an early arthritis cohort in Argentina

Abstract: Early arthritis clinics are a useful tool to identify and treat patients with different forms of joint involvement.

Cited by 24 publications

References 30 publications

Acompanhamento da capacidade funcional de pacientes com artrite reumatoide por três anos

Acompanhamento da capacidade funcional de pacientes com artrite reumatoide por três anos

Monitoring the functional capacity of patients with rheumatoid arthritis for three years

Limited Diagnostic and Prognostic Value of Routine Radiographs in Newly Presenting Arthritis Suspected of Rheumatoid Arthritis: A Retrospective Study

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