General Issues in Clinical Research of Acupuncture and In Vitro Fertilization

Zheng, Chenhong; Wan, Xiaoyang; Xu, Xiaohu; Zhang, Mingmin; Huang, Guang-ying; Wang, Wei

doi:10.1155/2020/3460641

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…Insufficient acupuncture dosage in IVF has been a common opinion (78). Some investigators suggested that a clinically valid dosage of acupuncture should be more than six acupuncture sessions and at least choose four to ten (or more) acupuncture points in each session (79). Further study should explore the specific effective dose of acupuncture treatment.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy benefit of acupuncture on in vitro fertilization: A systematic review and meta-analysis

Yan

Liu

et al. 2021

Preprint

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Background: The evidence of acupuncture for in vitro fertilization (IVF) remains debatable. Objectives: To evaluate the efficacy of acupuncture on embryo transfer in women undergoing IVF. Search Strategy: PubMed, MEDLINE, Web of Science, EMBASE, CENTRAL, Wanfang, Chinese National Knowledge Infrastructure, VIP were searched up to 6 September 2021. Selection Criteria: Randomized controlled trials (RCTs) of acupuncture evaluating IVF’s effects were included. Data Collection and Analysis: Clinical pregnancy rate (CPR) and live birth rate (LBR) were quantitatively summarized by the random-effect model. Variations in pooled estimates were examined by subgroup analyses and I2 was measured to quantify statistical heterogeneity. Main Results: Forty-nine eligible RCTs representing 9422 women undergoing IVF for pregnant success were identified. Pooled CPR and LBR showed a significant difference between acupuncture and control groups (odds ratio [OR]=1.65, 95% confidence interval [CI]: 1.45 to 1.88; OR=1.34, 95% CI: 1.08 to 1.66). Subgroup analysis showed a benefit of traditional acupuncture for women aged < 35 years (CPR: OR=1.57, 95% CI: 1.23 to 2.03; LBR: OR=1.34, 95% CI:1.23 to 1.48), treatment with  3 sessions (CPR: OR=2.37, 95% CI: 1.46 to 3.85; LBR: OR=1.99, 95% CI:1.52 to 2.60), and lower baseline control group rates of CPR (CPR: OR=2.14, 95% CI: 1.22 to 2.13; LBR: OR=2.23, 95% CI:1.07 to 4.62). Heterogeneity across studies were found (CPR: I2=47.4, p <0.001; LBR: I2=62.9, p <0.001). Conclusions: Although benefits of acupuncture in CPR and LBR among IVF women existed, no robust associations were found and which might be limited by the heterogeneity of current evidence

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Section: Discussionmentioning

confidence: 99%

Pregnancy benefit of acupuncture on in vitro fertilization: A systematic review and meta-analysis

Yan

Liu

et al. 2021

Preprint

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“…Both positive (3,(11)(12)(13)(14)(15)(16)(17) and negative (18-26) effects of acupuncture assisting IVF success were reported. The individualized treatment protocol, different control types, variate acupuncture timing, different searching databases, literature selection criteria, and outcome measures, all potentially contributed to the con icting results (9,27). Since most current trials used the original protocol of Paulus et al(28), the main in uencing factor across studies thereafter might be the types of acupuncture.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy Benefit of Acupuncture on in vitro Fertilization: A Systematic Review and Meta-Analysis

Zhang,

et al. 2023

Chin. J. Integr. Med.

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Background: This study reviewed published evidence of the e cacy of acupuncture among women undergoing in vitro fertilization (IVF).Methods: The database included PubMed, MEDLINE, Web of Science, EMBASE, CENTRAL, Wanfang, CNKI, VIP were searched up to May 24, 2022. The primary outcomes for clinical pregnancy rate (CPR) and live birth rate (LBR) were quantitatively summarized by the random-effect model with I 2 statistics to quantify heterogeneity.Results: Forty-nine eligible randomized clinical trials (RCTs)representing 9422 women undergoing IVF for pregnant success were identi ed. The results indicated that pooled CPR and LBR showed a signi cant difference between acupuncture and control groups [53 trials, odds ratio (OR)1.68, 95% con dence intervals (CI) 1.47 to 1.92, I 2 =47.4], extremely low evidence; 20 trials, OR1.37, 95%CI 1.11 to 1.69, I 2 =62.6, low evidence, respectively). Only transcutaneous electrical acupoint stimulation (TEAS) was found to be a positive effect on both CPR (10 trials, OR1.73, 95%CI 1.35 to 2.23; I 2 =28.1, moderate evidence) and LBR (7 trials, OR 1.74, 95%CI 1.23 to 2.46; I 2 =47.6, extremely low evidence). Heterogeneity across studies was found and no studies were graded as high quality of evidence.Conclusions: Our results showed that the association between acupuncture use and IVF pregnant outcomes were not supported by robust evidence and the varied methodological design and heterogeneity might in uence the ndings in a relevant way.Registration: PROSPERO CRD42021232430.

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Effect of Acupuncture on Endometrial Blood Flow in Women Undergoing in vitro Fertilization Embryo Transfer: A Single Blind, Randomized Controlled Trial

Dong

Qi-xin

et al. 2023

Chin. J. Integr. Med.

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General Issues in Clinical Research of Acupuncture and In Vitro Fertilization

Cited by 6 publications

References 33 publications

Pregnancy benefit of acupuncture on in vitro fertilization: A systematic review and meta-analysis

Pregnancy benefit of acupuncture on in vitro fertilization: A systematic review and meta-analysis

Pregnancy Benefit of Acupuncture on in vitro Fertilization: A Systematic Review and Meta-Analysis

Effect of Acupuncture on Endometrial Blood Flow in Women Undergoing in vitro Fertilization Embryo Transfer: A Single Blind, Randomized Controlled Trial

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