General, reproductive, developmental, and endocrine toxicity of boronated compounds

Fail, Patricia A.; Chapin, Robert E.; Price, Catherine J.; Heindel, Jerrold J.

doi:10.1016/s0890-6238(97)00095-6

Cited by 129 publications

(86 citation statements)

References 52 publications

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“…Boron compounds are toxic to all species tested at high doses, but they are not mutagenic or carcinogenic. The major chronic toxicities are developmental and reproductive [49].…”

Section: Boron Toxicitymentioning

confidence: 99%

Effect of Boron on Human Health

Bakırdere¹,

Orenay²,

Korkmaz³

2010

TOMPJ

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Studies on boron, its mechanism and health effects are growing although the safe limits of daily boron exposure have not been clarified. Current knowledge about the toxic levels of boron on humans is not sufficient and needs to be improved. The main toxic effect of boron in animals involves the reproductive system, including specific adverse effects in the male reproductive tract in rats, mice and dogs. Boron determination in biological matrices needs sufficiently sensitive procedures for detection at trace levels, and many techniques do exist. In this paper, we reviewed the general view of potential impact of boron on health, exposure of boron and its determination techniques.

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“…Boron compounds are toxic to all species tested at high doses, but they are not mutagenic or carcinogenic. The major chronic toxicities are developmental and reproductive [49].…”

Section: Boron Toxicitymentioning

confidence: 99%

Effect of Boron on Human Health

Bakırdere¹,

Orenay²,

Korkmaz³

2010

TOMPJ

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“…were observed, the dose-dependent effects are important in our study. It has been reported that BA is toxic to all species tested at high doses (Fail et al 1998). One thousand ppm BA (4.5 mmol B/kg b.wt.)…”

Section: Discussionmentioning

confidence: 99%

“…BA is abundant in nature. It is widely used in industrial, agricultural, cosmetic, and a numerous smaller applications (Fail 1998). Clarification of boron toxicity is important because of industrial and consumer exposure to boron and boron-containing compounds (Sabuncuoglu et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Acute toxicity of boric acid on energy metabolism of the breast muscle in broiler chickens

Geyikoğglu

Türkez

2007

Biologia

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Short-and long-term oral exposures to boric acid (BA) in laboratory animals and birds caused toxic effects. However, the toxicity data on adult poultry skeletal muscles of BA was not documented with metabolic studies. Livability, weight gain, and feed conversion might be adversely affected in broilers as a result of changes in energy metabolism. Therefore, this study was conducted to investigate the influences of acute BA doses on energy metabolism of chick pectoral muscle (PM). Chicks were fed by giving the aqueous solutions supplemented with BA (0, 0.27, 0.54, 1.08, 1.35, 2.25, 3.375 and 4.5 mmol B/kg b.wt.). Breast muscle samples were taken at 24, 48 and 72 h and analyzed histochemically, ultrastructurally and biochemically. Data collected in these analyses indicated that consumption of diets containing up to 2.25 mmol B/kg at 24, 48 and 72h was not detrimental to broiler PM. However, 3.375 mmol B/kg b.wt. (at 24 h) and 4.5 mmol B/kg b.wt.(at 24 and 48 h) caused decreased metabolite concentrations (glucose, glycogen, lactate and ATP) in muscle fibers (Type IIB). Subsarcolemmal (SS) mitochondria and intermyofibrillar (IM) mitochondrial damage (cristae dissolution) were also observed by toxic effect of BA (4.5 mmol B/kg b.wt.). These observations proved that BA at the high doses (3.375 and 4.5 mmol B/kg b.wt.) causes to altered energy metabolism in Type IIB as dependent on time. Based on these results we think that energy protection in muscle against BA toxicity will be the most important study subject. Thus, high BA doses will not have detrimental effects on broiler performance.

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“…First, the sensor is comprised of well-known compounds of low toxicity, making it much safer than cobalt (II) chloride sensors for humidity monitoring of pharmaceutical or food products [16][17][18][19][20] . Second, the preparation of the material for the sensor utilizes relatively mild chemicals and consists of a very simple process.…”

Section: Introductionmentioning

confidence: 99%

Colorimetric Humidity Sensor Based on Liquid Composite Materials for the Monitoring of Food and Pharmaceuticals

et al. 2014

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Using supported ionic-liquid membrane (SILM)-inspired methodologies, we have synthesized, characterized, and developed a humidity sensor by coating a liquid composite material on a hygroscopic and porous substrate. Similar to pH paper, the sensor responds to the environment's relative humidity and changes color accordingly. The humidity indicator is prepared by casting few microliters of low toxicity reagents on a non-toxic substrate. The sensing material is a newly synthesized liquid composite, which comprises a hygroscopic medium for environmental humidity capture, and a color indicator, which translates the humidity level into a distinct color change. Sodium borohydride was used to form a liquid composite medium and DenimBlu30 dye was used as a redox indicator. The liquid composite medium provides a hygroscopic response to relative humidity, and DenimBlu30 translates the chemical changes into a visual change from a yellow to blue color. The borate-redox dye based humidity sensor was prepared, then Fourier Transform Infrared Spectroscopy, Differential Scanning Calorimetry, and image analysis methods were used to characterize chemical composition, optimize synthesis, and gain insight into sensor reactivity. Test results indicated that this new sensing material can detect relative humidity in the range of 5-100% in an irreversible manner with good reproducibility and high accuracy. The sensor is a low cost, highly sensitive, and easy-to-use humidity indicator. More importantly, it can be easily packaged with products to monitor humidity levels in pharmaceutical and food packaging.

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General, reproductive, developmental, and endocrine toxicity of boronated compounds

Cited by 129 publications

References 52 publications

Effect of Boron on Human Health

Effect of Boron on Human Health

Acute toxicity of boric acid on energy metabolism of the breast muscle in broiler chickens

Colorimetric Humidity Sensor Based on Liquid Composite Materials for the Monitoring of Food and Pharmaceuticals

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