Generalizability of the surveillance, epidemiology, and end results registry population: Factors relevant to epidemiologic and health care research

Nattinger, Ann B.; McAuliffe, Timothy L.; Schapira, Marilyn M.

doi:10.1016/s0895-4356(97)00099-1

Cited by 198 publications

(105 citation statements)

References 22 publications

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“…According to SEER, inclusion of specific registries was based on their generalizable population demographics and ability to maintain high standards in cancer reporting. Age and sex characteristics of the SEER population are comparable to that of the United States; however, SEER data may account for a more urban and affluent population in comparison to the United States as a whole [20,24].…”

Section: Methodsmentioning

confidence: 99%

Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database

Schneiderman

Kliethermes

Nystrom

2017

Clinical Orthopaedics &Amp; Related Research

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Background Studies suggest that mesenchymal chondrosarcoma is associated with a poorer prognosis and a higher proportion of extraskeletal tumors than conventional chondrosarcoma. However, these investigations have been small heterogeneous cohorts, limiting analysis of prognostic factors. Questions/purposes (1) What is the 5-and 10-year survival rate of patients diagnosed with mesenchymal chondrosarcoma? (2) What is the effect of demographic and tumor characteristics on survival in patients with mesenchymal chondrosarcoma? Methods The Surveillance, Epidemiology, and End Results (SEER) database was used to identify all patients diagnosed with mesenchymal chondrosarcoma from 1973 to 2011. SEER reports survival data on over 8.2 million patients with cancer and has attained 98% completeness in reporting. Using variables within the database, this study designated each patient's tumor as skeletal or extraskeletal and cranial, axial, or appendicular, respectively. Overall survival (OS) was determined for the entire series as well as each group. Median survival was calculated using KaplanMeier methods. Cox proportional hazards regression was used to determine whether demographic and tumor variables affected survival. Two hundred five patients with mesenchymal chondrosarcoma were identified, including 82 (40%) skeletal and 123 (60%) extraskeletal. Results OS for the entire series was 51% (95% confidence interval [CI], 43%-58%) and 43% (95% CI, 35%-51%) at 5 and 10 years, respectively. No difference in OS was detected between extraskeletal and skeletal tumors. KaplanMeier analyses showed OS was worse for tumors in axial locations compared with appendicular and cranial locations. Appendicular tumors demonstrated an OS of 50% (95% CI, 36%-63%) at 5 years and 39% (95% CI, 26%-52%) at 10 years. OS for axial tumors was 37% (95% CI, 25%-49%) and 31% (95% CI, 20%-43%), whereas it was 74% (95% CI, 59%-84%) and 67% (95% CI, 50%-79%) for cranial tumors at 5 and 10 years, respectively. When controlling for age, sex, tumor origin, and tumor location, the presence of metastasis (hazard ratio [HR], 12.38; 95% CI, 5.75-26.65; p \ 0.001) and 1-cm size increase (HR, 1.16; 95% CI, 1.09-1.23; p \ 0.001) were both independently associated with an increased risk of death. Tumor location showed different behaviors depending on patient age. In comparison to cranial tumors at age 20 years, the HR was 5.56 (95% CI, 1.47-21.05; p = 0.01) for axial tumors and 6.26 (95% CI, 1.54-25.42; p = 0.01) for appendicular tumors. At age 60 years, those ratios were 0.10 (95% CI, 0.02-0.55; p = 0.01) and 0.14 (95% CI, 0.04-0.58; p = 0.01), respectively. Conclusions Our data suggest that extraskeletal tumors are more common than previously reported; however, this factor does not have clear prognostic value. Presence of metastatic disease and increased tumor size are the main Each author certifies that he or she, or a member of his or her immediate family, has no funding or commercial associations (eg, consultancies, stock ownership, equity interest, paten...

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Section: Methodsmentioning

confidence: 99%

Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database

Schneiderman

Kliethermes

Nystrom

2017

Clinical Orthopaedics &Amp; Related Research

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“…When comparing the SEER data with the overall US population, it is apparent that those residing within the SEER areas are more affluent, have lower unemployment, and are substantially more urban than the rest of the US population. 49 These problems of generalizability can affect the validity of the confidence intervals presented here.…”

Section: Limitationsmentioning

confidence: 98%

Incidence and relative survival of chordomas

Smoll

Gautschi

Radovanović

et al. 2013

Cancer

168

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BACKGROUND: Chordomas are rare bone tumors arising from remnants of the embryonic notochord. METHODS: Data for this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute to calculate the incidence, relative survival (RS), and standardized mortality ratio (SMR) of patients diagnosed with intracranial and extracranial chordomas and to assess the effects of age and sex on this disease. RESULTS: The overall incidence of extracranial and intracranial chordomas was 8.4 per 10 million population. The median overall survival of patients with chordoma patients was 7.7 years. The median survival was 7.7 years for male patients and 7.8 years for female patients. Younger patients (aged <40 years) survived longer compared with older patients (10-year RS, 68% vs 43%). The estimated age-standardized 5-year, 10-year, and 20-year RS rates was 72%, 48%, and 31%, respectively. The SMR in the overall cohort was 4.6 (95% confidence interval, 4.22-5.0) or 21.0 (95% confidence interval, 16.6-27.2) in young adult patients and 3.0 (95% confidence interval, 2.6-3.4) in elderly patients. CONCLUSIONS: The elderly had a more aggressive form of this disease; and, other than the incidence, sex did not influence outcome in this disease. The study of chordomas presents a good case for the contribution that the SMR can have on measuring the impact of a disease on a population of patients. Although the younger population has better survival rates, the impact (SMR) in the younger age groups is much higher than in older populations.

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“…No SEER county with a substantial AA population (at least 5%) was classified as rural by the 1990 Census. 40 Thus, SEER breast cancer data for AA women reflect the incidence and survival patterns for a highly urban AA female population. In addition, this population likely has higher socioeconomic status compared with the AA female population at large, because 20 SEER counties with substantial numbers of AA residents had significantly higher levels of education and income compared with non-SEER counties that had similar numbers of AA residents.…”

Section: Representativeness Of Aa Populations Covered By Surveillancementioning

confidence: 99%

“…In addition, this population likely has higher socioeconomic status compared with the AA female population at large, because 20 SEER counties with substantial numbers of AA residents had significantly higher levels of education and income compared with non-SEER counties that had similar numbers of AA residents. 40 Because higher regional socioeconomic status has been associated previously with elevated breast cancer rates in AA populations, 5,19 breast cancer patterns gleaned from SEER data may overestimate incidence for the AA female population at large. This possibility has been raised previously with the observation that breast cancer rates in predominantly black, rural counties in North Carolina and Georgia are substantially lower compared with the overall SEER rate.…”

Section: Representativeness Of Aa Populations Covered By Surveillancementioning

confidence: 99%

Existing data on breast cancer in African-American women

Clarke

West

Edwards

et al. 2002

Cancer

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Generalizability of the surveillance, epidemiology, and end results registry population: Factors relevant to epidemiologic and health care research

Cited by 198 publications

References 22 publications

Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database

Survival in Mesenchymal Chondrosarcoma Varies Based on Age and Tumor Location: A Survival Analysis of the SEER Database

Incidence and relative survival of chordomas

Existing data on breast cancer in African-American women

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