2014
DOI: 10.2215/cjn.02300213
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Generalization of Associations of Kidney-Related Genetic Loci to American Indians

Abstract: SummaryBackground and objectives CKD disproportionally affects American Indians, who similar to other populations, show genetic susceptibility to kidney outcomes. Recent studies have identified several loci associated with kidney traits, but their relevance in American Indians is unknown.Design, setting, participants, & measurements This study used data from a large, family-based genetic study of American Indians (the Strong Heart Family Study), which includes 94 multigenerational families enrolled from commun… Show more

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Cited by 20 publications
(18 citation statements)
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“…To date, 10 different AI‐causing mutations in WDR72 have been reported, and all showed a recessive pattern of inheritance of hypomaturation AI . By a genome‐wide association study, WDR72 was also associated with kidney function and chronic kidney diseases, and single‐nucleotide polymorphisms on WDR72 were also found to be associated with the glomerulus filtration rate variance in American Indians . The Wdr72 knockout mice showed defective dental enamel formation without the appearance of other organ abnormalities .…”
Section: Discussionmentioning
confidence: 99%
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“…To date, 10 different AI‐causing mutations in WDR72 have been reported, and all showed a recessive pattern of inheritance of hypomaturation AI . By a genome‐wide association study, WDR72 was also associated with kidney function and chronic kidney diseases, and single‐nucleotide polymorphisms on WDR72 were also found to be associated with the glomerulus filtration rate variance in American Indians . The Wdr72 knockout mice showed defective dental enamel formation without the appearance of other organ abnormalities .…”
Section: Discussionmentioning
confidence: 99%
“…In addition, interactome analysis of the WDR72 protein has revealed potential interactions with clathrin‐associated proteins involved in ameloblastic endocytosis. Moreover, the mislocalization of sodium/potassium/calcium exchanger (NCKX4), a critical ameloblast calcium transporter encoded by SLC24A4 , away from the distal membrane of the ameloblast was detected in WDR72 −/− mice, suggesting that the disturbance of calcium from the ameloblast might cause hypomaturation …”
Section: Discussionmentioning
confidence: 99%
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“…2010; Franceschini et al. 2014). WDR72 is well conserved in birds, such as chickens and finches, suggesting that there are selective pressures that maintain WDR72 in birds, which have evolutionarily lost their teeth.…”
Section: Discussionmentioning
confidence: 99%