Generalized buUous and haemorrhagic lichen sclerosus et atrophicus*

Silverio, A. Di; Serri, F

doi:10.1111/j.1365-2133.1975.tb06744.x

Cited by 33 publications

(12 citation statements)

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“…There are several anecdotal reports of the success and failure of hydroxychloroquine and etretinate in BLSA 6 . Other authors have successfully used corticotropin and para ‐aminobenzoate 7,8 . Tangential partial‐thickness excision resulted in an extended remission in one case of localized BLSA 9 .…”

Section: Reportmentioning

confidence: 99%

Extensive bullous lichen sclerosus with scarring alopecia

Madan

Cox

2009

Clinical and Experimental Dermatology

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We describe details of a very rare variant of lichen sclerosus in an elderly man. This pattern was characterized by involvement of most of the body surface by bullae, erosions and scarring, including scarring alopecia. Our patient responded to topical corticosteroids and doxycycline. Borrelia spp. have been implicated in a previous case of this variant, but we could not find any evidence of this in our patient.

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Section: Reportmentioning

confidence: 99%

Extensive bullous lichen sclerosus with scarring alopecia

Madan

Cox

2009

Clinical and Experimental Dermatology

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“…Occasionally hemorrhagic transformation or blister formation occurs due to basal cell degeneration resulting in dermal-epidermal separation and marked edema in upper dermis. Bullous LSA has been described in a localized[5] and generalized[89] distribution, and often the vesicles and bullae have a hemorrhagic component. Telangiectases and purpura may occur.…”

Section: Discussionmentioning

confidence: 99%

“…[3] Marked improvement in generalized bullous and haemorrhagic LSA has been reported with Adrenocorticotropic hormone in one patient. [8] The bullous lesions are usually transient and heal before typical plaques of the disease,[9] which are more resistant to treatment.…”

Section: Discussionmentioning

confidence: 99%

Isolated, localised extragenital bullous Lichen sclerosus et atrophicus: A rare entity

Khatu¹,

Vasani²

2013

Indian J Dermatol

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Lichen sclerosus et atrophicus (LSA) is a rare, chronic, mucocutaneous disease of unknown cause. Onset can occur in subjects of any age but more prevalent in adult females around the time of menopause. In both the sexes anogenital involvement is more common. Extragenital cases are rare, and common localizations are neck and shoulders, axilla, upper arms, flexor aspects of wrists and around the umbilicus. Bullous LSA is an unusual manifestation of the disease. Isolated extragenital bullous LSA is a distinctly rare event with very few cases reported till date.

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“…Hemorrhagic blisters have rarely been described developing in the background of either genital or extragenital lichen sclerosus. Such lesions have invariably been designated clinically as telangiectatic, hemorrhagic or bullous lichen sclerosus 5–8 …”

Section: Discussionmentioning

confidence: 99%

Angiokeratoma‐like changes in extragenital and genital lichen sclerosus

Luzar¹,

Neil

Calonje³

2009

J Cutan Pathol

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Hemorrhagic blisters have rarely been described developing in the background of either genital or extragenital lichen sclerosus and have invariably been designated clinically as telangiectatic, hemorrhagic or bullous lichen sclerosus. We describe three patients with extragenital and genital lichen sclerosus, who presented clinically with hemorrhagic plaques and/or papules. In addition to the classical histology of lichen sclerosus, dilated, congested and focally thrombosed vascular channels lined by flat endothelium were seen within the sclerotic dermal collagen. They were in close proximity to and even in contact with the overlying epidermis and thus mimicked an angiokeratoma. Angiokeratoma-like changes in lichen sclerosus represent secondary features because of damage to the dermis by lichen sclerosus and are characterized histologically by ectatic thin-walled vascular spaces in the papillary dermis intimately associated with the epidermis. Increased venous pressure, local trauma, degenerative changes in the elastic tissue of the vessel wall and/or surrounding supportive tissue, as well as abnormalities in the extracellular protein network, appear to be implicated in their pathogenesis.

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Generalized buUous and haemorrhagic lichen sclerosus et atrophicus*

Abstract: SUMMARY An unusual case of lichen sclerosus et atrophicus is described, in which lesions were bullous and haemorrhagic and extended over almost the entire stirface of the skin. A marked improvement followed treatment with ACTH.

Cited by 33 publications

References 0 publications

Extensive bullous lichen sclerosus with scarring alopecia

Extensive bullous lichen sclerosus with scarring alopecia

Isolated, localised extragenital bullous Lichen sclerosus et atrophicus: A rare entity

Angiokeratoma‐like changes in extragenital and genital lichen sclerosus

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