Generalized calcinosis cutis associated with probable leptospirosis in a dog

Munday, John S.; Bergen, David J.; Roe, Wendi D.

doi:10.1111/j.1365-3164.2005.00476.x

Cited by 14 publications

(18 citation statements)

References 14 publications

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“…There was no evidence of argyrophilic Leptospires with silver staining, although this technique can fail to identify Leptospires during acute leptospirosis ( Greene and others 2006 ). With the exception of calcinosis cutis, which was not identified in any dog in this series, skin lesions have not previously been reported in association with canine leptospirosis ( Munday and others 2005 ).…”

Section: Discussioncontrasting

confidence: 53%

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK

Holm

Hawkins²,

Robin

et al. 2015

Veterinary Record

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To describe the signalment, clinicopathological findings and outcome in dogs presenting with acute kidney injury (AKI) and skin lesions between November 2012 and March 2014, in whom cutaneous and renal glomerular vasculopathy (CRGV) was suspected and renal thrombotic microangiopathy (TMA) was histopathologically confirmed. The medical records of dogs with skin lesions and AKI, with histopathologically confirmed renal TMA, were retrospectively reviewed. Thirty dogs from across the UK were identified with clinicopathological findings compatible with CRGV. These findings included the following: skin lesions, predominantly affecting the distal extremities; AKI; and variably, anaemia, thrombocytopaenia and hyperbilirubinaemia. Known causes of AKI were excluded. The major renal histopathogical finding was TMA. All thirty dogs died or were euthanised. Shiga toxin was not identified in the kidneys of affected dogs. Escherichia coli genes encoding shiga toxin were not identified in faeces from affected dogs. CRGV has previously been reported in greyhounds in the USA, a greyhound in the UK, without renal involvement, and a Great Dane in Germany. This is the first report of a series of non-greyhound dogs with CRGV and AKI in the UK. CRGV is a disease of unknown aetiology carrying a poor prognosis when azotaemia develops.

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Section: Discussioncontrasting

confidence: 53%

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK

Holm

Hawkins²,

Robin

et al. 2015

Veterinary Record

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“…Young dogs with leptospirosis have been reported to develop severe systemic or skin calcifications (Munday et al . , Michel et al . ).…”

Section: Clinical Findingsmentioning

confidence: 99%

European consensus statement on leptospirosis in dogs and cats

Schuller

Francey

Hartmann

et al. 2015

J of Small Animal Practice

241

377

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Leptospirosis is a zoonotic disease with a worldwide distribution affecting most mammalian species. Clinical leptospirosis is common in dogs but appears to be rare in cats. Both dogs and cats, however, can shed leptospires in the urine. This is problematic as it can lead to exposure of humans. The control of leptospirosis, therefore, is important not only from an animal but also from a public health perspective. The aim of this consensus statement is to raise awareness of leptospirosis and to outline the current knowledge on the epidemiology, clinical features, diagnostic tools, prevention and treatment measures relevant to canine and feline leptospirosis in Europe.

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“…9 Furthermore, conditions causing inflammation in the skin, such as follicular cysts, foreign body granulomas, interdigital pyoderma, demodicosis or pilomatrixomas, have also been reported to be associated with dystrophic calcification and ossification. 2,9,10 Dogs and chinchillas are the only known species of animals that develop CC in response to hyperadrenocorticism. 11 Idiopathic CC has a histological appearance similar to glucocorticoid-induced CC.…”

Section: Introductionmentioning

confidence: 99%

Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases

Doerr

Outerbridge

White

et al. 2013

Veterinary Dermatology

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Background -Calcinosis cutis is well recognized in dogs with endogenous hyperglucocorticism and iatrogenic hyperglucocorticism, but the pathogenesis is still unclear.Objectives -The objectives of the study were to identify possible correlations between histopathological patterns of dermal mineralization in skin biopsies and underlying causes for calcinosis cutis in dogs, as well as to determine breed predilection and age of onset for dogs within a hospital population. In addition, mineral analysis was performed on four biopsy samples.Animals -Forty-six dogs with histopathologically confirmed calcinosis cutis were evaluated.Methods -Medical records and histological sections of dogs with calcinosis cutis diagnosed by histopathology over a 21 year period were reviewed. Infrared spectrometry was used to identify the mineral in the paraffin blocks. Exact chi-squared test was used to identify breed predispositions, while a Mann-Whitney U-test was used to identify age correlations.Results -Labrador retrievers, Rottweilers, boxers and Staffordshire terriers were the breeds most commonly affected in this study. Most dogs had either an exogenous or an endogenous source of corticosteroids, with the exception of five dogs with renal insufficiency. In the majority of cases, mineralization was found throughout the entire dermis. The average age of onset of calcinosis cutis for dogs with endogenous hyperglucocorticism was older than that of dogs with iatrogenic hyperglucocorticism. Using infrared spectrometry, apatite crystals were found to be the source of mineral.Conclusions and clinical importance -There was no observable difference in the histopathological pattern of calcinosis cutis from dogs with endogenous hyperglucocorticism versus iatrogenic hyperglucocorticism. While glucocorticoid therapy appears to predispose dogs to developing calcinosis cutis, it remains unclear whether there is a specific dose or combination of factors that initiates the mineral deposition. Furthermore, the mineral deposition in dogs with calcinosis cutis was found to be apatite.

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Generalized calcinosis cutis associated with probable leptospirosis in a dog

Cited by 14 publications

References 14 publications

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK

Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK

European consensus statement on leptospirosis in dogs and cats

Calcinosis cutis in dogs: histopathological and clinical analysis of 46 cases

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